KEGG   ENZYME: 1.2.1.31Help
Entry
EC 1.2.1.31                 Enzyme                                 

Name
L-aminoadipate-semialdehyde dehydrogenase;
aminoadipate semialdehyde dehydrogenase;
2-aminoadipate semialdehyde dehydrogenase;
alpha-aminoadipate-semialdehyde dehydrogenase;
alpha-aminoadipate reductase;
2-aminoadipic semialdehyde dehydrogenase;
L-alpha-aminoadipate delta-semialdehyde oxidoreductase;
L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase;
L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase;
L-2-aminoadipate 6-semialdehyde:NAD(P)+ 6-oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-2-amino-6-oxohexanoate:NAD(P)+ 6-oxidoreductase
Reaction(IUBMB)
(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+ (overall reaction) [RN:R03102 R03103];
(1a) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous) [RN:R02317];
(1b) (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD(P)+ + 2 H2O = L-2-aminoadipate + NAD(P)H + H+ [RN:R11231 R11232]
Reaction(KEGG)
Substrate
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate [CPD:C00450]
Product
L-2-aminoadipate [CPD:C00956];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate [CPD:C00450];
H2O [CPD:C00001]
Comment
(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.
History
EC 1.2.1.31 created 1972, modified 2011
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K14085  aldehyde dehydrogenase family 7 member A1
Genes
HSA: 501(ALDH7A1)
PTR: 462033(ALDH7A1)
PPS: 100970731(ALDH7A1)
GGO: 101148545(ALDH7A1) 101149382 109025015
PON: 100461726(ALDH7A1)
NLE: 100583462(ALDH7A1)
MCC: 702749(ALDH7A1)
MCF: 102120771(ALDH7A1)
CSAB: 103245164(ALDH7A1)
RRO: 104677423(ALDH7A1)
RBB: 108537700(ALDH7A1)
CJC: 100401828(ALDH7A1) 100410565(ALDH7A1) 103790723
SBQ: 101045920(ALDH7A1)
MMU: 110695(Aldh7a1)
RNO: 291450(Aldh7a1)
CGE: 100756509(Aldh7a1)
NGI: 103740420(Aldh7a1)
HGL: 101711696(Aldh7a1)
CCAN: 109699996(Aldh7a1)
OCU: 100344302(ALDH7A1)
TUP: 102495542(ALDH7A1)
CFA: 481486(ALDH7A1)
AML: 100475712(ALDH7A1)
UMR: 103670577(ALDH7A1)
ORO: 101372739(ALDH7A1)
FCA: 101086623(ALDH7A1)
PTG: 102951788(ALDH7A1)
AJU: 106970741(ALDH7A1)
BTA: 507477(ALDH7A1)
BOM: 102285292(ALDH7A1)
BIU: 109561847(ALDH7A1)
PHD: 102334119(ALDH7A1)
CHX: 102187125(ALDH7A1)
OAS: 101108127(ALDH7A1)
SSC: 106504110(ALDH7A1)
CFR: 102512958(ALDH7A1)
CDK: 105089785(ALDH7A1)
BACU: 103018812 103019170(ALDH7A1)
LVE: 103087111(ALDH7A1)
OOR: 101279003(ALDH7A1)
ECB: 100063766(ALDH7A1)
EPZ: 103557440(ALDH7A1)
EAI: 106842819(ALDH7A1)
MYB: 102247575(ALDH7A1)
MYD: 102754535(ALDH7A1)
HAI: 109379078(ALDH7A1)
RSS: 109440683 109447739(ALDH7A1)
PALE: 102880590(ALDH7A1)
LAV: 100656260(ALDH7A1)
TMU: 101361542
MDO: 100009965(ALDH7A1)
SHR: 100930576(ALDH7A1)
OAA: 100074256(ALDH7A1)
GGA: 426812(ALDH7A1)
MGP: 104915364(ALDH7A1)
CJO: 107306701(ALDH7A1)
APLA: 101793275(ALDH7A1)
ACYG: 106046528(ALDH7A1)
TGU: 100223716(ALDH7A1)
GFR: 102042249(ALDH7A1)
FAB: 101806923(ALDH7A1)
PHI: 102106824(ALDH7A1)
PMAJ: 107198296(ALDH7A1)
CCAE: 111941214(ALDH7A1)
CCW: 104690506(ALDH7A1)
FPG: 101917601(ALDH7A1)
FCH: 102052577(ALDH7A1)
CLV: 102091436(ALDH7A1)
EGZ: 104124248(ALDH7A1)
AAM: 106498570(ALDH7A1)
ASN: 102368427(ALDH7A1)
AMJ: 102563610(ALDH7A1)
PSS: 102458471(ALDH7A1)
CMY: 102940167(ALDH7A1)
CPIC: 101937973(ALDH7A1)
ACS: 100560663(aldh7a1)
PVT: 110077534(ALDH7A1)
PBI: 103049565(ALDH7A1)
GJA: 107112391(ALDH7A1)
XLA: 108707197(aldh7a1.S) 447522(aldh7a1.L)
XTR: 549131(aldh7a1)
NPR: 108799792(ALDH7A1)
DRE: 334197(aldh7a1)
SRX: 107715563(aldh7a1)
SANH: 107657454(aldh7a1)
SGH: 107573911(aldh7a1)
CCAR: 109097311(aldh7a1)
IPU: 108277325(aldh7a1)
AMEX: 103034062(aldh7a1)
TRU: 101066288(aldh7a1)
LCO: 104931924(aldh7a1)
NCC: 104947674(aldh7a1)
MZE: 101482988(aldh7a1)
OLA: 101157525(aldh7a1)
XMA: 102233064(aldh7a1)
PRET: 103464136(aldh7a1)
NFU: 107392683(aldh7a1)
KMR: 108230647(aldh7a1)
CSEM: 103393055(aldh7a1)
LCF: 108881294(aldh7a1)
SDU: 111217230(aldh7a1)
HCQ: 109522068(aldh7a1)
BPEC: 110160079(aldh7a1)
MALB: 109958202(aldh7a1)
SASA: 100194754(aldh7a1)
OTW: 112220006(aldh7a1)
ELS: 105021749(aldh7a1)
SFM: 108929860(aldh7a1)
LCM: 102353526 102356888(ALDH7A1)
CMK: 103182361(aldh7a1)
CIN: 100184485
SPU: 588376
APLC: 110981183
SKO: 100370075
DME: Dmel_CG9629(CG9629)
DER: 6543557
DPE: 6602384
DSI: Dsimw501_GD12292(Dsim_GD12292)
DWI: 6643070
MDE: 101888197
AME: 411140
BIM: 100747121
BTER: 100648169
SOC: 105195464
AEC: 105151044
ACEP: 105619807
PBAR: 105422187
HST: 105181543
DQU: 106746805
CFO: 105258160
LHU: 105668398
PGC: 109862314
PCF: 106790004
MDL: 103568681
TCA: 658395
DPA: 109541213
NVL: 108564650
BMOR: 101735616
PRAP: 110996914
HAW: 110372538
API: 100159019
DNX: 107173527
CLEC: 106664902
ZNE: 110841255
FCD: 110857963
TUT: 107369629
CEL: CELE_F01F1.6(alh-9)
CBR: CBG09070(Cbr-alh-9)
CRG: 105327683
MYI: 110455019
OBI: 106871909
EPA: 110236278
HMG: 100198995(aldh7a1)
ATH: AT1G54100(ALDH7B4)
CRB: 17897673
BRP: 103832634
THJ: 104815620
CPAP: 110818468
CIT: 102620491
GRA: 105773235
GHI: 107900603
EGR: 104450978
GMX: 100811186 547717(TP55)
VRA: 106762243
VAR: 108331606
CCAJ: 109817465
CAM: 101513733
LJA: Lj6g3v1177340.1(Lj6g3v1177340.1)
ADU: 107479115
AIP: 107630450
LANG: 109326919
FVE: 101298824
PPER: 18770979
PMUM: 103340601
PAVI: 110749149
ZJU: 107423905
CSV: 101205436
CMO: 103500684
MCHA: 111021324
CMAX: 111488616
CMOS: 111455986
CPEP: 111807264
JCU: 105631377
JRE: 109009030
SLY: 101252968
SPEN: 107014931
SOT: 102598345
CANN: 107861672
NSY: 104236891
NTO: 104107938
SIND: 105157813
OEU: 111402278
HAN: 110886479
LSV: 111910340
CCAV: 112516483
DCR: 108228021
SOE: 110804032
NNU: 104600531
OSA: 4347172
DOSA: Os09t0440300-01(Os09g0440300)
OBR: 102721194
BDI: 100831288
ATS: 109774117(LOC109774117)
SBI: 8080995
SITA: 101759802
PDA: 103709342
EGU: 105042090
MUS: 103995197
DCT: 110096635
PEQ: 110026035
AOF: 109845011
ATR: 18439499
PPP: 112278756
CNE: CNA07130
CNB: CNBA6940
ABP: AGABI1DRAFT114711(AGABI1DRAFT_114711)
ABV: AGABI2DRAFT194900(AGABI2DRAFT_194900)
DFA: DFA_02437
SPAR: SPRG_06143
 » show all
Taxonomy
Reference
1  [PMID:4285660]
  Authors
Calvert AF, Rodwell VW.
  Title
Metabolism of pipecolic acid in a Pseudomonas species. 3. L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase.
  Journal
J Biol Chem 241:409-14 (1966)
Reference
2
  Authors
Rodwell, V.W.
  Title
Delta1-piperideine-6-carboxylic acid and alpha-aminoadipic acid delta-semialdehyde.
  Journal
Method Enzymol 17B:188-199 (1971)
Reference
3  [PMID:9355735]
  Authors
de La Fuente JL, Rumbero A, Martin JF, Liras P
  Title
Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing  actinomycetes.
  Journal
Biochem J 327 ( Pt 1):59-64 (1997)
Reference
4  [PMID:11098140]
  Authors
Fujii T, Narita T, Agematu H, Agata N, Isshiki K
  Title
Cloning and characterization of pcd encoding delta'-piperideine-6-carboxylate dehydrogenase from flavobacterium lutescens IFO3084.
  Journal
J Biochem 128:975-82 (2000)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.31
IUBMB Enzyme Nomenclature: 1.2.1.31
ExPASy - ENZYME nomenclature database: 1.2.1.31
BRENDA, the Enzyme Database: 1.2.1.31
CAS: 9067-87-2

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