KEGG   ENZYME: 1.2.1.4Help
Entry
EC 1.2.1.4                  Enzyme                                 

Name
aldehyde dehydrogenase (NADP+);
NADP-acetaldehyde dehydrogenase;
NADP-dependent aldehyde dehydrogenase;
aldehyde dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
aldehyde:NADP+ oxidoreductase
Reaction(IUBMB)
an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+ [RN:R00634]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.2.1.4 created 1961
Pathway
ec00930  Caprolactam degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14519  NADP-dependent aldehyde dehydrogenase
Genes
POL: Bpro_2298
AAV: Aave_0115
AAA: Acav_0148
PDE: Pden_3264
HBA: Hbal_2501
MGO: AFA91_18385
NBR: O3I_014410
RHA: RHA1_ro02898 RHA1_ro08151
REB: XU06_29340
ROP: ROP_04960 ROP_33690
SCO: SCO1871(SCI39.18c)
SALB: XNR_4954
SGB: WQO_07195
SCT: SCAT_1069(aldH)
SFA: Sfla_4940
SBH: SBI_08125
SHY: SHJG_3333
SVE: SVEN_1516
STRP: F750_1741
SFI: SFUL_1445
SALU: DC74_2375
SALL: SAZ_13230
STRE: GZL_06632
STRM: M444_09735
SAMB: SAM23877_1946(aldH)
SPRI: SPRI_6598
SRW: TUE45_02355(aldH)
SLE: sle_52630(sle_52630)
SRN: A4G23_01098(aldH)
CMI: CMM_0812
CMS: CMS0069
ART: Arth_3335
ARR: ARUE_c34530(aldH)
ARM: ART_2596
AAU: AAur_3317(aldH)
ACH: Achl_3135
BCV: Bcav_0786
LMOI: VV02_11040
NCA: Noca_0086
KFL: Kfla_6632
TFU: Tfu_1706
NDA: Ndas_5346
NAL: B005_1809
SRO: Sros_1486
GOB: Gobs_2395
AMD: AMED_5971
AMN: RAM_30625
AMM: AMES_5887
AMZ: B737_5887
AOI: AORI_3623(aldH) AORI_4998(aldH)
PDX: Psed_4281
KAL: KALB_6874
ACTI: UA75_13535
ACAD: UA74_13450
CAI: Caci_7805
SNA: Snas_4113
CWO: Cwoe_3952
RBA: RB1887
 » show all
Taxonomy
Reference
1
  Authors
Adachi, O., Matsushita, K., Shinagawa, E. and Ameyama, M.
  Title
Crystallization and properties of NADP-dependent aldehyde dehydrogenase from Gluconobacter melanogenus.
  Journal
Agric Biol Chem 44:155-164 (1980)
Reference
2
  Authors
Jakoby, W.B.
  Title
Aldehyde dehydrogenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
Reference
3
  Authors
Nakayama, T.
  Title
Acetic acid bacteria. II. Intracellular distribution of enzymes related to acetic acid fermentation, and some properties of a highly purified triphosphopyridine nucleotide (TPN)-dependent aldehyde dehydrogenase.
  Journal
J Biochem (Tokyo) 48:812-830 (1960)
Reference
4  [PMID:13061400]
  Authors
SEEGMILLER JE.
  Title
Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast.
  Journal
J Biol Chem 201:629-37 (1953)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.4
IUBMB Enzyme Nomenclature: 1.2.1.4
ExPASy - ENZYME nomenclature database: 1.2.1.4
BRENDA, the Enzyme Database: 1.2.1.4
CAS: 9028-87-9

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