KEGG   ENZYME: 1.2.1.48Help
Entry
EC 1.2.1.48                 Enzyme                                 

Name
long-chain-aldehyde dehydrogenase;
long-chain aliphatic aldehyde dehydrogenase;
long-chain fatty aldehyde dehydrogenase;
fatty aldehyde:NAD+ oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
long-chain-aldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
a long-chain aldehyde + NAD+ + H2O = a long-chain carboxylate + NADH + 2 H+ [RN:R02039]
Reaction(KEGG)
Substrate
long-chain aldehyde [CPD:C00609];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
long-chain carboxylate [CPD:C00347];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The best substrate is dodecylaldehyde.
History
EC 1.2.1.48 created 1984
Pathway
ec00071  Fatty acid degradation
Reference
1  [PMID:5499619]
  Authors
Lebeault JM, Roche B, Duvnjak Z, Azoulay E.
  Title
[Alcohol and aldehyde dehydrogenases of Candida tropicalis cultivated on hydrocarbons]
  Journal
Biochim Biophys Acta 220:373-85 (1970)
DOI:10.1016/0005-2744(70)90269-X
Reference
2  [PMID:36040]
  Authors
Moreau RA, Huang AH.
  Title
Oxidation of fatty alcohol in the cotyledons of jojoba seedlings.
  Journal
Arch Biochem Biophys 194:422-30 (1979)
DOI:10.1016/0003-9861(79)90636-2
Reference
3
  Authors
Moreau, R.A. and Huang, A.H.C.
  Title
Enzymes of wax ester catabolism in jojoba.
  Journal
Methods Enzymol 71:804-813 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.48
IUBMB Enzyme Nomenclature: 1.2.1.48
ExPASy - ENZYME nomenclature database: 1.2.1.48
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.48
BRENDA, the Enzyme Database: 1.2.1.48
CAS: 59298-89-4

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