KEGG   ENZYME: 1.2.1.5Help
Entry
EC 1.2.1.5                  Enzyme                                 

Name
aldehyde dehydrogenase [NAD(P)+];
ALDH
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
aldehyde:NAD(P)+ oxidoreductase
Reaction(IUBMB)
an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + H+ [RN:R00538 R00634]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.2.1.5 created 1961
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00340  Histidine metabolism
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00410  beta-Alanine metabolism
ec00980  Metabolism of xenobiotics by cytochrome P450
ec00982  Drug metabolism - cytochrome P450
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00129  aldehyde dehydrogenase (NAD(P)+)
Genes
HSA: 218(ALDH3A1) 220(ALDH1A3) 221(ALDH3B1) 222(ALDH3B2)
PTR: 453686(ALDH1A3) 466685(ALDH3B2) 468186(ALDH3A1) 747335(ALDH3B1)
PPS: 100967518(ALDH1A3) 100970713(ALDH3A1) 100992841(ALDH3B2) 100993681(ALDH3B1)
GGO: 101131216(ALDH3A1) 101135029(ALDH1A3) 101144902 101147407(ALDH3B1)
PON: 100446485(ALDH3A1) 100450634(ALDH3B1) 100452276(ALDH1A3) 100453112(ALDH3B2)
NLE: 100582304 100582987(ALDH3B1) 100585710(ALDH3A1) 100586116(ALDH1A3)
MCC: 694231(ALDH1A3) 703870(ALDH3A1) 710746(ALDH3B1) 721683(ALDH3B2)
MCF: 102115665(ALDH1A3) 102120140(ALDH3B1) 102122172(ALDH3B2) 102140050(ALDH3A1)
CSAB: 103216001(ALDH3B1) 103216342(ALDH3B2) 103231285(ALDH1A3) 103242519(ALDH3A1)
RRO: 104663273(ALDH3A1) 104664720(ALDH3B1) 104664722(ALDH3B2) 104676802(ALDH1A3)
RBB: 108518605 108518676(ALDH3B1) 108521944(ALDH3A1) 108522929(ALDH1A3) 108524521
CJC: 100385438(ALDH3A1) 100397394(ALDH1A3) 100399356 100405175(ALDH3B1) 100408282
SBQ: 101028257(ALDH3B2) 101053003(ALDH3A1) 101054138(ALDH1A3) 101054144(ALDH3B1)
MMU: 11670(Aldh3a1) 56847(Aldh1a3) 621603(Aldh3b2) 67689(Aldh3b1) 73458(Aldh3b3)
RNO: 25375(Aldh3a1) 266603(Aldh1a3) 309147(Aldh3b1) 688778 688800(Aldh3b2)
CGE: 100755596 100756470 100757371(Aldh3a1) 100763332(Aldh3b2) 100768227(Aldh1a3)
NGI: 103724848(Aldh3a1) 103744514(Aldh3b1) 103747192(Aldh1a3) 103749592
HGL: 101699453(Aldh3a1) 101700669(Aldh1a3) 101722793(Aldh3b1) 101724442(Aldh3b2)
CCAN: 109685045(Aldh1a3) 109688192(Aldh3a1) 109692072 109692074(Aldh3b1)
OCU: 100356011(ALDH1A3) 103346087(ALDH3B1)
TUP: 102470787 102474716(ALDH3B1) 102475132 102490907(ALDH3A1) 102491549(ALDH1A3)
CFA: 100856346(ALDH1A3) 476003(ALDH3B1) 489526(ALDH3A1)
AML: 100467493(ALDH3B2) 100467748(ALDH3B1) 100467752(ALDH1A3) 100482437(ALDH3A1)
UMR: 103658510(ALDH3A1) 103660039(ALDH1A3) 103679525 103679621(ALDH3B1)
ORO: 101364411(ALDH3A1) 101376873(ALDH3B1) 101377457 101381188(ALDH1A3)
FCA: 101081050(ALDH1A3) 101094208(ALDH3B1) 101096364(ALDH3A1) 105259663
PTG: 102952022(ALDH1A3) 102953099(ALDH3A1) 102964294(ALDH3B2) 102969525(ALDH3B1)
AJU: 106971094(ALDH3B1) 106971159 106972083(ALDH1A3) 106981410
BTA: 281617(ALDH3A1) 507093(ALDH1A3) 508879 511469(ALDH3B1)
BOM: 102267436 102267473(ALDH3B1) 102269123(ALDH3A1) 102273352 102284286(ALDH1A3)
BIU: 109553910 109554323(ALDH3B1) 109554325 109573432(ALDH3A1) 109575619(ALDH1A3)
PHD: 102331077(ALDH3A1) 102332149(ALDH3B1) 102337504 102344693(ALDH1A3)
CHX: 102179701(ALDH3A1) 102179885(ALDH1A3) 102185156 102185988(ALDH3B1)
OAS: 101108502(ALDH3A1) 101109831(ALDH1A3) 101111922 101112687
SSC: 100522421 100526075(ALDH3A1) 100739347(ALDH3B1) 102162530(ALDH1A3)
CFR: 102504927(ALDH1A3) 102508421 102511953 102512509(ALDH3A1) 102521023(ALDH3B1)
CDK: 105085091(ALDH3A1) 105093453(ALDH1A3) 105104409(ALDH3B1) 105104411(ALDH3B2) 105106740
BACU: 103000712(ALDH3A1) 103004940(ALDH3B1) 103013550(ALDH1A3)
LVE: 103068962(ALDH3B1) 103078726(ALDH3B2) 103082981(ALDH1A3) 103083340(ALDH3A1)
OOR: 101271204(ALDH3B2) 101273844(ALDH3A1) 101279390(ALDH1A3) 101290322(ALDH3B1)
ECB: 100053296 100053339(ALDH3B1) 100057072(ALDH1A3) 100073157(ALDH3A1)
EPZ: 103540930(ALDH3A1) 103543617 103544300 103557113(ALDH1A3)
EAI: 106833481(ALDH3B2) 106838852(ALDH3A1) 106839471(ALDH1A3) 106844279(ALDH3B1)
MYB: 102241863(ALDH1A3) 102255064 102255772(ALDH3B1) 102260012(ALDH3A1)
MYD: 102758582(ALDH1A3) 102761807(ALDH3B1) 102762385(ALDH3B2) 102774766(ALDH3A1)
HAI: 109380344(ALDH1A3) 109382162(ALDH3A1) 109384135 109384136
RSS: 109444900(ALDH1A3) 109450388 109450498 109461281(ALDH3A1)
PALE: 102888323 102889864(ALDH1A3) 102889891(ALDH3A1) 102895234(ALDH3B1)
LAV: 100657867 100667345(ALDH3B1) 100667915 100671859(ALDH1A3)
MDO: 100010416(ALDH3B1) 100020100 100020131(ALDH3A1) 100616732(ALDH1A3)
OAA: 100077088(ALDH3A1) 100083368(ALDH1A3)
GGA: 395389(ALDH1A3) 428812(ALDH3B1L1) 428813(ALDH3B1L2)
MGP: 100546607(ALDH1A3) 100548799 100548954(ALDH3B1)
CJO: 107314145(ALDH3B1) 107318982(ALDH1A3)
APLA: 101793139(ALDH1A3) 101796911(ALDH3B1) 101798585 106020656
ACYG: 106036495(ALDH1A3) 106048259(ALDH3B1) 106048260
TGU: 100231202(ALDH1A3) 100232483(ALDH3B1)
GFR: 102032126 102032291(ALDH3B1) 102037159(ALDH1A3)
FAB: 101809399 101809598(ALDH3B1) 101816772(ALDH1A3)
PHI: 102103263 102103447(ALDH3B1) 102105549(ALDH1A3)
PMAJ: 107205327 107205328 107209559(ALDH1A3)
CCW: 104683903(ALDH1A3) 104692991(ALDH3B1)
FPG: 101915870(ALDH1A3) 101919850(ALDH3B1) 101920028
FCH: 102050613(ALDH1A3) 102058490 102058662(ALDH3B1) 102058835
CLV: 102089147(ALDH1A3) 102096341(ALDH3B1)
AAM: 106487924(ALDH3B1) 106487925 106487939 106495827(ALDH1A3)
ASN: 102368111(ALDH1A3) 102380358 102380930 102385864(ALDH3B1)
AMJ: 102560126 102560360(ALDH3B1) 102560807 102573093(ALDH1A3)
PSS: 102450892(ALDH1A3)
CMY: 102931111 102936985(ALDH3B1) 102939103(ALDH1A3)
CPIC: 101932058(ALDH3B1) 101937286 101946404(ALDH1A3)
PVT: 110072975(ALDH1A3) 110085672(ALDH3B1)
XLA: 108711844 108712817 447062(aldh3b1.L) 733178(aldh1a3.L)
XTR: 100145787(aldh3b2) 100485844(aldh1a3) 548883(aldh3b1)
DRE: 282559(aldh3b1) 557008(aldh3b2) 751785(aldh1a3)
IPU: 108258475(ALDH3B1) 108271441(aldh1a3)
AMEX: 103032207(aldh1a3) 103038420
LCO: 104921301 104929720(aldh1a3) 104935243(aldh3b1) 109142068
OLA: 101157544 101158531(aldh3b1)
XMA: 102225391(aldh3b1) 102230203 102232034(aldh1a3)
PRET: 103462270(aldh1a3) 103468182(aldh3b1) 103470338
HCQ: 109511573
BPEC: 110162488
ELS: 105014397(aldh1a3) 105030765
LCM: 102361849(ALDH3B1) 102366661(ALDH1A3)
CMK: 103173942 103187716(aldh1a3)
DME: Dmel_CG11140(Aldh-III)
FCD: 110852080
TUT: 107360456
SCE: YMR169C(ALD3) YMR170C(ALD2)
ERC: Ecym_3381
KMX: KLMA_20672(aldA) KLMA_20673(ALD2)
NCS: NCAS_0D00880(NCAS0D00880)
NDI: NDAI_0H03250(NDAI0H03250)
TDL: TDEL_0G02690(TDEL0G02690)
KAF: KAFR_0B04820(KAFR0B04820)
PIC: PICST_63844(ALD2)
SPAA: SPAPADRAFT_59619(ALD2)
CAL: CAALFM_CR04870CA(CaO19.6306)
CAUR: QG37_08146
SLB: AWJ20_1884(ALD2) AWJ20_1916(ALD5)
NCR: NCU00378
NTE: NEUTE1DRAFT42209(NEUTE1DRAFT_42209)
MGR: MGG_05008
CMT: CCM_08195
MBE: MBM_03637
ANG: ANI_1_1748184(An04g03400)
ABE: ARB_05929
TVE: TRV_00129
ZTR: MYCGRDRAFT_39109(ALD2)
DDI: DDB_G0292270(comG)
DFA: DFA_09276(comG)
PNA: Pnap_4188
ADE: Adeh_1143
AVA: Ava_3615
CCH: Cag_1754
 » show all
Taxonomy
Reference
1  [PMID:14904038]
  Authors
BLACK S.
  Title
Yeast aldehyde dehydrogenase.
  Journal
Arch Biochem 34:86-97 (1951)
DOI:10.1016/S0003-9861(51)80013-4
Reference
2
  Authors
Jakoby, W.B.
  Title
Aldehyde dehydrogenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
Reference
3  [PMID:13319337]
  Authors
KING TE, CHELDELIN VH.
  Title
Oxidation of acetaldehyde by Acetobacter suboxydans.
  Journal
J Biol Chem 220:177-91 (1956)
Reference
4  [PMID:4293780]
  Authors
Steinman CR, Jakoby WB.
  Title
Yeast aldehyde dehydrogenase. I. Purification and crystallization.
  Journal
J Biol Chem 242:5019-23 (1967)
Reference
5  [PMID:13363916]
  Authors
TANENBAUM SW.
  Title
The metabolism of Acetobacter peroxidans.  I.  Oxidative enzymes.
  Journal
Biochim Biophys Acta 21:335-42 (1956)
DOI:10.1016/0006-3002(56)90017-8
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.5
IUBMB Enzyme Nomenclature: 1.2.1.5
ExPASy - ENZYME nomenclature database: 1.2.1.5
BRENDA, the Enzyme Database: 1.2.1.5
CAS: 9028-88-0

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