KEGG ENZYME: 1.2.1.58

ENZYME: 1.2.1.58

Entry

EC 1.2.1.58                 Enzyme

Name

phenylglyoxylate dehydrogenase (acylating)

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

phenylglyoxylate:NAD+ oxidoreductase

Reaction(IUBMB)

phenylglyoxylate + NAD+ + CoA = benzoyl-S-CoA + CO2 + NADH [RN:R02450]

Reaction(KEGG)

R02450

Substrate

phenylglyoxylate [CPD:C02137];
NAD+ [CPD:C00003];
CoA [CPD:C00010]

Product

benzoyl-S-CoA;
CO2 [CPD:C00011];
NADH [CPD:C00004]

Comment

Requires thiamine diphosphate as cofactor. The enzyme from the denitrifying bacterium Azoarcus evansii is specific for phenylglyoxylate. 2-Oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate. Also reduces viologen dyes. Contains iron-sulfur centres and FAD.

History

EC 1.2.1.58 created 1999

Pathway

ec00360

Phenylalanine metabolism

ec01100

Metabolic pathways

Orthology

K18355

phenylglyoxylate dehydrogenase alpha subunit

K18356

phenylglyoxylate dehydrogenase beta subunit

K18357

phenylglyoxylate dehydrogenase gamma subunit

K18358

phenylglyoxylate dehydrogenase delta subunit

K18359

phenylglyoxylate dehydrogenase epsilon subunit

Genes

SHD:	SUTH_01625(padE) SUTH_01626(padF) SUTH_01627(padG) SUTH_01628(padH) SUTH_01629(padI)

EBA:	ebA5397(padE) ebA5399(padG) ebA5400(padH) ebA5401(padI) ebB191(padF)

ABRE:

pbN1_03600(padI1) pbN1_03610 pbN1_03620 pbN1_03630 pbN1_03640(padE1) pbN1_13490(padI2) pbN1_13500(padH1) pbN1_13510(padG1) pbN1_13520(padF1) pbN1_13530(padE2) pbN1_22260(padI3) pbN1_22270(padH2) pbN1_22280(padG2) pbN1_22290(padF2) pbN1_22300(padE3)

APET:

ToN1_00290(padI1) ToN1_00300(padH1) ToN1_00310(padG1) ToN1_00320(padF1) ToN1_00330(padE1) ToN1_39560(padE2) ToN1_39570(padF2) ToN1_39580(padG2) ToN1_39590(padH2) ToN1_39600(padI2)

AZA:	AZKH_2897(padI) AZKH_2898(padH) AZKH_2899(padG) AZKH_2900(padF) AZKH_2901(padE)

AZI:	AzCIB_1802 AzCIB_1803 AzCIB_1804 AzCIB_1805 AzCIB_1806 AzCIB_2838 AzCIB_2839 AzCIB_2840 AzCIB_2841 AzCIB_2842

AZD:	CDA09_15475 CDA09_15480 CDA09_15485 CDA09_15490 CDA09_15495

TMZ:	Tmz1t_2962 Tmz1t_2963 Tmz1t_2964 Tmz1t_2965 Tmz1t_2966

TCL:	Tchl_2132 Tchl_2133 Tchl_2134 Tchl_2135 Tchl_2136

TAK:	Tharo_1290 Tharo_1291 Tharo_1292 Tharo_1293 Tharo_1294

DDZ:	DSYM_12680 DSYM_12690 DSYM_12700 DSYM_12710 DSYM_12720

RPD:	RPD_1510 RPD_1511 RPD_1512 RPD_1513 RPD_1514

MAGX:

XM1_3886(padI) XM1_3887(padH) XM1_3888(padG) XM1_3889 XM1_3890(padE)

MAGN:

WV31_20645 WV31_20650 WV31_20655 WV31_20660 WV31_20665

MAG:	amb1676 amb1677 amb1678 amb1679 amb1680

DTO:	TOL2_C41570(padE2) TOL2_C41580(padF2) TOL2_C41590(padG2) TOL2_C41600(padH2) TOL2_C41610(padI2)

PFAA:

MM59RIKEN_15720 MM59RIKEN_15730

CHYL:

CE91St63_20510(porA)

» show all

Reference

1 [PMID:9490067]

Authors

Hirsch W, Schagger H, Fuchs G

Title

Phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating), a new enzyme of anaerobic phenylalanine metabolism in the denitrifying bacterium Azoarcus evansii.

Journal

Eur J Biochem 251:907-15 (1998)
DOI:10.1046/j.1432-1327.1998.2510907.x

Sequence

[ag:CAD21691 CAD21693 CAD21689 CAD21690 CAD21692]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.58

IUBMB Enzyme Nomenclature:

1.2.1.58

ExPASy - ENZYME nomenclature database:

1.2.1.58

BRENDA, the Enzyme Database:

1.2.1.58

CAS:	205510-78-7

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