KEGG   ENZYME: 1.2.1.63Help
Entry
EC 1.2.1.63                 Enzyme                                 

Name
6-oxohexanoate dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
6-oxohexanoate:NADP+ oxidoreductase
Reaction(IUBMB)
6-oxohexanoate + NADP+ + H2O = adipate + NADPH + 2 H+ [RN:R05099]
Reaction(KEGG)
Substrate
6-oxohexanoate [CPD:C06102];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
adipate [CPD:C06104];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Last step in the cyclohexanol degradation pathway in Acinetobacter sp.
History
EC 1.2.1.63 created 2000
Pathway
ec00930  Caprolactam degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K19962  6-oxohexanoate dehydrogenase
Genes
PPJ: RK21_02870
Taxonomy
Reference
1  [PMID:856571]
  Authors
Davey JF, Trudgill PW.
  Title
The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species.
  Journal
Eur J Biochem 74:115-27 (1977)
DOI:10.1111/j.1432-1033.1977.tb11373.x
Reference
2  [PMID:1261]
  Authors
Donoghue NA, Trudgill PW.
  Title
The metabolism of cyclohexanol by Acinetobacter NCIB 9871.
  Journal
Eur J Biochem 60:1-7 (1975)
DOI:10.1111/j.1432-1033.1975.tb20968.x
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.63
IUBMB Enzyme Nomenclature: 1.2.1.63
ExPASy - ENZYME nomenclature database: 1.2.1.63
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.63
BRENDA, the Enzyme Database: 1.2.1.63
CAS: 62628-29-9

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