KEGG   ENZYME: 1.2.1.65Help
Entry
EC 1.2.1.65                 Enzyme                                 

Name
salicylaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
salicylaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
salicylaldehyde + NAD+ + H2O = salicylate + NADH + 2 H+ [RN:R02941]
Reaction(KEGG)
Substrate
salicylaldehyde [CPD:C06202];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
salicylate [CPD:C00805];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in the naphthalene degradation pathway in some bacteria.
History
EC 1.2.1.65 created 2000, modified 2011
Pathway
ec00626  Naphthalene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00152  salicylaldehyde dehydrogenase
Genes
PPI: ND058(nahF)
PSC: A458_06710
PSTU: UIB01_22640
PBM: CL52_14625
PFK: PFAS1_28625
RMN: TK49_07965
BMK: DM80_1446
PARB: CJU94_38645
PNA: Pnap_2482
Taxonomy
Reference
1  [PMID:1447127]
  Authors
Eaton RW, Chapman PJ.
  Title
Bacterial metabolism of naphthalene: construction and use of recombinant bacteria to study ring cleavage of 1,2-dihydroxynaphthalene and subsequent reactions.
  Journal
J Bacteriol 174:7542-54 (1992)
DOI:10.1128/JB.174.23.7542-7554.1992
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.65
IUBMB Enzyme Nomenclature: 1.2.1.65
ExPASy - ENZYME nomenclature database: 1.2.1.65
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.65
BRENDA, the Enzyme Database: 1.2.1.65
CAS: 55354-34-2

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