KEGG   ENZYME: 1.2.1.69Help
Entry
EC 1.2.1.69                 Enzyme                                 

Name
fluoroacetaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
fluoroacetaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+ [RN:R07156]
Reaction(KEGG)
Substrate
fluoroacetaldehyde [CPD:C15488];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
fluoroacetate [CPD:C06108];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.
History
EC 1.2.1.69 created 2003
Reference
1  [PMID:11571203]
  Authors
Murphy CD, Moss SJ, O'Hagan D.
  Title
Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya.
  Journal
Appl Environ Microbiol 67:4919-21 (2001)
  Sequence
[sct:SCAT_0945]
Reference
2  [PMID:12738270]
  Authors
Murphy CD, Schaffrath C, O'Hagan D.
  Title
Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya.
  Journal
Chemosphere 52:455-61 (2003)
DOI:10.1016/S0045-6535(03)00191-7
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.69
IUBMB Enzyme Nomenclature: 1.2.1.69
ExPASy - ENZYME nomenclature database: 1.2.1.69
BRENDA, the Enzyme Database: 1.2.1.69
CAS: 387336-50-7

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