KEGG   ENZYME: 1.2.1.75Help
Entry
EC 1.2.1.75                 Enzyme                                 

Name
malonyl-CoA reductase (malonate semialdehyde-forming);
NADP-dependent malonyl CoA reductase;
malonyl CoA reductase (NADP);
malonyl CoA reductase (malonate semialdehyde-forming)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming)
Reaction(IUBMB)
malonate semialdehyde + CoA + NADP+ = malonyl-CoA + NADPH + H+ [RN:R00740]
Reaction(KEGG)
Substrate
malonate semialdehyde [CPD:C00222];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively [1,2]. The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits [3]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the next reaction in the pathway, EC 1.1.1.298 [3-hydroxypropionate dehydrogenase (NADP+)] [4].
History
EC 1.2.1.75 created 2009
Pathway
ec00640  Propanoate metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
Orthology
K14468  malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+)
K15017  malonyl-CoA/succinyl-CoA reductase (NADPH)
Genes
RRS: RoseRS_3201
RCA: Rcas_2929
CAU: Caur_2614
CHL: Chy400_2826
CAG: Cagg_1256
CTM: Cabther_B0159
STO: STK_21710(mcr_scr)
SSO: SSO2178(asd-2)
SOL: Ssol_2908
SSOA: SULA_2921
SSOL: SULB_2921
SSOF: SULC_2918
SID: M164_2777
SII: LD85_3126
SIH: SiH_2755
SIR: SiRe_2691
SIC: SiL_2637
MSE: Msed_0709
MCN: Mcup_1427
AHO: Ahos_2348
 » show all
Taxonomy
Reference
1  [PMID:8354269]
  Authors
Strauss G, Fuchs G
  Title
Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle.
  Journal
Eur J Biochem 215:633-43 (1993)
DOI:10.1111/j.1432-1033.1993.tb18074.x
Reference
2  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
  Sequence
[mse:Msed_0709]
Reference
3  [PMID:17041055]
  Authors
Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hugler M, Fuchs G
  Title
Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.
  Journal
J Bacteriol 188:8551-9 (2006)
DOI:10.1128/JB.00987-06
  Sequence
[mse:Msed_0709] [sto:STK_21710]
Reference
4  [PMID:11948153]
  Authors
Hugler M, Menendez C, Schagger H, Fuchs G
  Title
Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:2404-10 (2002)
DOI:10.1128/JB.184.9.2404-2410.2002
  Sequence
[cau:Caur_2614]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.75
IUBMB Enzyme Nomenclature: 1.2.1.75
ExPASy - ENZYME nomenclature database: 1.2.1.75
BRENDA, the Enzyme Database: 1.2.1.75

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