KEGG   ENZYME: 1.2.1.76Help
Entry
EC 1.2.1.76                 Enzyme                                 

Name
succinate-semialdehyde dehydrogenase (acylating);
succinyl-coA reductase;
coenzyme-A-dependent succinate-semialdehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
succinate semialdehyde + CoA + NADP+ = succinyl-CoA + NADPH + H+ [RN:R09280]
Reaction(KEGG)
Substrate
succinate semialdehyde [CPD:C00232];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
succinyl-CoA [CPD:C00091];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde. The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation [1], and in Metallosphaera sedula, where it participates in the 3-hydroxypropanonate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [2,3].
History
EC 1.2.1.76 created 2009
Pathway
ec00650  Butanoate metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15017  malonyl-CoA/succinyl-CoA reductase (NADPH)
K15038  succinyl-CoA reductase
K18119  succinate-semialdehyde dehydrogenase
Genes
BGJ: AWC36_10870
CKL: CKL_3015(sucD)
CKR: CKR_2663
CSQ: CSCA_3620
CEU: A7L45_11960
LACY: A4V08_31365
CDF: CD630_23420(sucD)
PDC: CDIF630_02581(sucD)
CDC: CD196_2185(sucD)
CDL: CDR20291_2231(sucD)
PDF: CD630DERM_23420(sucD)
PGI: PG_0687(sucD)
PGN: PGN_0723
PGT: PGTDC60_1813(sucD)
TFO: BFO_1488
STO: STK_00640 STK_21710(mcr_scr)
SSO: SSO1629(gapN-1) SSO1842(gapN-2) SSO2178(asd-2)
SOL: Ssol_2908
SSOA: SULA_2921
SSOL: SULB_2921
SSOF: SULC_2918
MCN: Mcup_1427
PIS: Pisl_0249
PCL: Pcal_1387
PYR: P186_0719
POG: Pogu_1297
TNE: Tneu_0421
CMA: Cmaq_0073
TTN: TTX_1101
 » show all
Taxonomy
Reference
1  [PMID:8444151]
  Authors
Sohling B, Gottschalk G
  Title
Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri.
  Journal
Eur J Biochem 212:121-7 (1993)
DOI:10.1111/j.1432-1033.1993.tb17641.x
  Sequence
Reference
2  [PMID:17041055]
  Authors
Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hugler M, Fuchs G
  Title
Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.
  Journal
J Bacteriol 188:8551-9 (2006)
DOI:10.1128/JB.00987-06
Reference
3  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
  Sequence
[mse:Msed_0709]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.76
IUBMB Enzyme Nomenclature: 1.2.1.76
ExPASy - ENZYME nomenclature database: 1.2.1.76
BRENDA, the Enzyme Database: 1.2.1.76

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