KEGG   ENZYME: 1.2.1.77Help
Entry
EC 1.2.1.77                 Enzyme                                 

Name
3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+);
BoxD;
3,4-dehydroadipyl-CoA semialdehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3,4-didehydroadipyl-CoA semialdehyde:NADP+ oxidoreductase
Reaction(IUBMB)
3,4-didehydroadipyl-CoA semialdehyde + NADP+ + H2O = 3,4-didehydroadipyl-CoA + NADPH + H+ [RN:R09554]
Reaction(KEGG)
Substrate
3,4-didehydroadipyl-CoA semialdehyde [CPD:C19683];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
3,4-didehydroadipyl-CoA [CPD:C19682];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme catalyses a step in the aerobic benzoyl-coenzyme A catabolic pathway in Azoarcus evansii and Burkholderia xenovorans.
History
EC 1.2.1.77 created 2010
Pathway
ec00362  Benzoate degradation
Orthology
K15514  3,4-dehydroadipyl-CoA semialdehyde dehydrogenase
Genes
VFF: VITFI_CDS1598
RPJ: N234_31300
REH: H16_B1917(h16_B1917)
CNC: CNE_2c18770(boxD)
CUH: BJN34_32115
CTI: RALTA_B1616
CBW: RR42_s3015
CGD: CR3_3377(putA)
CCUP: BKK81_26765
CUP: BKK80_29550
BXB: DR64_3583(paaN) DR64_7555(paaN)
BFN: OI25_2712(paaN)
PPNO: DA70_23840
PPNM: LV28_06870
PPUL: RO07_00955
PSPU: NA29_10710
PAPI: SG18_01130
BPT: Bpet3573(paaZ2)
BHO: D560_2017(boxD)
BHM: D558_2002(boxD)
BHZ: ACR54_04088(boxD)
RFR: Rfer_0217
POL: Bpro_1625
PNA: Pnap_2947
VPD: VAPA_1c00920(paaN)
CTES: O987_00470
LIH: L63ED372_02249(boxD)
HYR: BSY239_632(boxD)
HYB: Q5W_16400
CBAA: SRAA_0582
LCH: Lcho_3656
THI: THI_0471
EBA: ebA2759(boxZ)
AZO: azo3054
AZA: AZKH_4516(boxZ)
AOA: dqs_3188
TCL: Tchl_1105
CCRO: CMC5_025740(aldA)
MAG: amb0173
MAGX: XM1_1068(maoC)
MAGN: WV31_13515
 » show all
Taxonomy
Reference
1  [PMID:16585753]
  Authors
Gescher J, Ismail W, Olgeschlager E, Eisenreich W, Worth J, Fuchs G
  Title
Aerobic benzoyl-coenzyme A (CoA) catabolic pathway in Azoarcus evansii: conversion of ring cleavage product by 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase.
  Journal
J Bacteriol 188:2919-27 (2006)
DOI:10.1128/JB.188.8.2919-2927.2006
  Sequence
Reference
2  [PMID:18462753]
  Authors
Bains J, Boulanger MJ
  Title
Structural and biochemical characterization of a novel aldehyde dehydrogenase encoded by the benzoate oxidation pathway in Burkholderia xenovorans LB400.
  Journal
J Mol Biol 379:597-608 (2008)
DOI:10.1016/j.jmb.2008.04.031
  Sequence
[bxe:Bxe_A1420]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.77
IUBMB Enzyme Nomenclature: 1.2.1.77
ExPASy - ENZYME nomenclature database: 1.2.1.77
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.77
BRENDA, the Enzyme Database: 1.2.1.77

DBGET integrated database retrieval system