KEGG   ENZYME: 1.2.1.84Help
Entry
EC 1.2.1.84                 Enzyme                                 

Name
alcohol-forming fatty acyl-CoA reductase;
FAR (gene name);
long-chain acyl-CoA:NADPH reductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
NADPH:long-chain acyl-CoA reductase
Reaction(IUBMB)
a long-chain acyl-CoA + 2 NADPH + 2 H+ = a long-chain alcohol + 2 NADP+ + CoA [RN:R10104]
Reaction(KEGG)
R10104;
(other) R09470
Show
Substrate
long-chain acyl-CoA [CPD:C02843];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain alcohol [CPD:C00339];
NADP+ [CPD:C00006];
CoA [CPD:C00010]
Comment
The enzyme has been characterized from the plant Simmondsia chinensis (jojoba). The alcohol is formed by a four-electron reduction of fatty acyl-CoA. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. The recombinant enzyme was shown to accept saturated and mono-unsaturated fatty acyl-CoAs of 16 to 22 carbons.
History
EC 1.2.1.84 created 2012
Pathway
ec00073  Cutin, suberine and wax biosynthesis
Orthology
K13356  alcohol-forming fatty acyl-CoA reductase
Genes
HSA: 55711(FAR2) 84188(FAR1)
PTR: 451036(FAR1) 473394(FAR2)
PPS: 100970220(FAR1) 100978448(FAR2)
GGO: 101130936(FAR2) 101143672 101145992(FAR1)
PON: 100173178(FAR1) 100444768(FAR2)
NLE: 100603620 100603920(FAR1) 100607476(FAR2)
MCC: 699947(FAR1) 710740(FAR2)
MCF: 102133388(FAR2) 102144566(FAR1) 107126496
CSAB: 103218802(FAR2) 103239852(FAR1)
RRO: 104657252(FAR2) 104681949(FAR1)
RBB: 108531946(FAR2) 108535526(FAR1)
CJC: 100399954(FAR1)
SBQ: 101030718(FAR2) 101033305(FAR1)
MMU: 330450(Far2) 67420(Far1)
RNO: 293173(Far1) 500368(Far2)
CGE: 100758702 100761128(Far1)
NGI: 103737780(Far2) 103750421(Far1)
HGL: 101701162(Far2) 101721496(Far1)
CCAN: 109687542(Far1) 109703239(Far2)
OCU: 100351559(FAR1) 100353600(FAR2)
TUP: 102474742(FAR1) 102482710(FAR2)
CFA: 476863(FAR1) 477658(FAR2)
AML: 100467017(FAR2) 100481513(FAR1)
UMR: 103656127(FAR2) 103682371(FAR1)
ORO: 101363510(FAR1) 101366795(FAR2)
FCA: 101086070(FAR2) 101093138(FAR1)
PTG: 102964902(FAR2) 102966354(FAR1)
AJU: 106971852(FAR1) 106977440(FAR2)
BTA: 525262(FAR1) 534380(FAR2)
BOM: 102274086(FAR2) 102276400(FAR1)
BIU: 109559560(FAR2) 109569597(FAR1)
PHD: 102325105(FAR1) 102326079(FAR2)
CHX: 102186751(FAR2) 102191256(FAR1)
OAS: 101109003(FAR2) 101119501(FAR1)
SSC: 100512348(FAR2) 100625473(FAR1)
CFR: 102505508(FAR2) 102522950(FAR1)
CDK: 105086690(FAR1) 105103939(FAR2)
BACU: 103001187(FAR2) 103009399(FAR1)
LVE: 103072652 103083253(FAR2)
OOR: 101272789(FAR1) 101276761(FAR2)
ECB: 100069466(FAR2) 100071555(FAR1)
EPZ: 103558710(FAR1) 103560922(FAR2)
EAI: 106832876(FAR2) 106833080(FAR1)
MYB: 102245111(FAR2) 102257915(FAR1)
MYD: 102756698(FAR2) 102761437(FAR1)
HAI: 109388276(FAR1) 109396817(FAR2)
PALE: 102879243(FAR2) 102892976(FAR1)
LAV: 100671247(FAR2) 100674337(FAR1)
MDO: 100013219(FAR2) 100021793(FAR1)
SHR: 100916924(FAR2) 100920845(FAR1)
OAA: 100076543(FAR1)
GGA: 419043(FAR2) 423028(FAR1)
MGP: 100540589 100548530(FAR2)
CJO: 107314579(FAR1) 107317961(FAR2)
APLA: 101798823(FAR1) 101799736(FAR2)
ACYG: 106030876(FAR2) 106040872(FAR1)
TGU: 100223368(FAR1) 100227890
GFR: 102035761(FAR1) 102040510
FAB: 101806815(FAR1) 101809170(FAR2)
PHI: 102107199(FAR1) 102110477
PMAJ: 107205003 107206028(FAR1)
CCAE: 111923362 111930857(FAR1)
CCW: 104692963(FAR1) 104696112
FPG: 101921490(FAR1) 101921561(FAR2)
FCH: 102049306(FAR1) 102052339(FAR2)
CLV: 102088109(FAR1) 102094496(FAR2)
EGZ: 104123413(FAR1) 104124219(FAR2)
AAM: 106488889(FAR2) 106497108(FAR1)
ASN: 102381240 102381656(FAR1)
AMJ: 102561989(FAR2) 102574878(FAR1)
PSS: 102455834(FAR2) 102456918(FAR1)
CMY: 102930779(FAR1) 102933779
CPIC: 101931748(FAR1) 101934674(FAR2)
GJA: 107111800(FAR1) 107114318
XLA: 379278(far1.L) 399063
XTR: 100038270(far1)
NPR: 108789663(FAR1)
DRE: 100034578(si:dkey-97m3.1)
IPU: 108269172(far2) 108279482(far1)
TRU: 101069439(far1) 101078787
LCO: 104925325 104933352(far1)
PRET: 103459112 103466253(far1)
CSEM: 103379701(far2) 103382720
ELS: 105018254(far1) 105023414
SFM: 108920911(far2) 108931988 108941185(far1)
CMK: 103175059(far1) 103186227
CIN: 100177355
SPU: 584999
APLC: 110975040
SKO: 100368979
DME: Dmel_CG10096(CG10096) Dmel_CG10097(CG10097) Dmel_CG12268(CG12268) Dmel_CG13091(CG13091) Dmel_CG1441(CG1441) Dmel_CG1443(wat) Dmel_CG14893(CG14893) Dmel_CG17560(CG17560) Dmel_CG17562(CG17562) Dmel_CG18031(FarO) Dmel_CG30427(CG30427) Dmel_CG34342(CG34342) Dmel_CG4020(CG4020) Dmel_CG4770(CG4770) Dmel_CG5065(CG5065) Dmel_CG8306(CG8306)
DSI: Dsimw501_GD10039(Dsim_GD10039) Dsimw501_GD11210(Dsim_GD11210) Dsimw501_GD13195(Dsim_GD13195) Dsimw501_GD16765(Dsim_GD16765) Dsimw501_GD18004(Dsim_GD18004) Dsimw501_GD18334(Dsim_GD18334) Dsimw501_GD19114(Dsim_GD19114) Dsimw501_GD19115(Dsim_GD19115) Dsimw501_GD19116(Dsim_GD19116) Dsimw501_GD19323(Dsim_GD19323) Dsimw501_GD20573(Dsim_GD20573) Dsimw501_GD20574(Dsim_GD20574) Dsimw501_GD23553(Dsim_GD23553) Dsimw501_GD24908(Dsim_GD24908) Dsimw501_GD25529(Dsim_GD25529) Dsimw501_GD27572(Dsim_GD27572)
DWI: 6647413
CEL: CELE_Y71H10A.2(fard-1)
CBR: CBG02021
BMY: Bm1_37285
EPA: 110233845
HMG: 100202061
ATH: AT3G11980(MS2) AT3G44540(FAR4) AT3G44550(FAR5) AT3G44560(FAR8) AT3G56700(FAR6) AT4G33790(CER4) AT5G22420(FAR7) AT5G22500(FAR1)
LJA: Lj0g3v0102449.1(Lj0g3v0102449.1) Lj0g3v0113569.1(Lj0g3v0113569.1) Lj0g3v0144589.1(Lj0g3v0144589.1) Lj3g3v1147060.1(Lj3g3v1147060.1) Lj3g3v1148100.1(Lj3g3v1148100.1) Lj3g3v2995730.1(Lj3g3v2995730.1) Lj3g3v2995750.1(Lj3g3v2995750.1) Lj3g3v2995780.1(Lj3g3v2995780.1) Lj3g3v2995910.1(Lj3g3v2995910.1) Lj3g3v2995910.2(Lj3g3v2995910.2) Lj5g3v0747190.1(Lj5g3v0747190.1)
DOSA: Os03t0167600-01(Os03g0167600) Os04t0353600-01(Os04g0353600) Os04t0354400-00(Os04g0354400) Os04t0354600-01(Os04g0354600) Os04t0355500-00(Os04g0355500) Os07t0489100-00(Os07g0489100) Os08t0298700-01(Os08g0298700) Os08t0557800-01(Os08g0557800) Os09t0567500-01(Os09g0567500)
ATS: 109733393(LOC109733393) 109733744(LOC109733744) 109734593(LOC109734593) 109738484(LOC109738484) 109746696(LOC109746696) 109755090(LOC109755090) 109755858(LOC109755858) 109756186(LOC109756186) 109756814(LOC109756814) 109757488(LOC109757488) 109757816(LOC109757816) 109762606(LOC109762606) 109764486(LOC109764486) 109774349(LOC109774349) 109776709(LOC109776709) 109781118(LOC109781118)
PDA: 103715392
SMIN: v1.2.001382.t1(symbB.v1.2.001382.t1) v1.2.016916.t1(symbB.v1.2.016916.t1)
SPAR: SPRG_08800
TCR: 511909.10
MAD: HP15_810(far1)
 » show all
Taxonomy
Reference
1  [PMID:10712526]
  Authors
Metz JG, Pollard MR, Anderson L, Hayes TR, Lassner MW.
  Title
Purification of a jojoba embryo fatty acyl-coenzyme A reductase and expression of its cDNA in high erucic acid rapeseed.
  Journal
Plant Physiol 122:635-44 (2000)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.84
IUBMB Enzyme Nomenclature: 1.2.1.84
ExPASy - ENZYME nomenclature database: 1.2.1.84
BRENDA, the Enzyme Database: 1.2.1.84

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