KEGG   ENZYME: 1.2.1.85Help
Entry
EC 1.2.1.85                 Enzyme                                 

Name
2-hydroxymuconate-6-semialdehyde dehydrogenase;
xylG (gene name);
praB (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-hydroxymuconate-6-semialdehyde:NAD+ oxidoreductase
Reaction(IUBMB)
2-hydroxymuconate-6-semialdehyde + NAD+ + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+ [RN:R02762]
Reaction(KEGG)
R02762;
(other) R05353
Show
Substrate
2-hydroxymuconate-6-semialdehyde [CPD:C00682];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate;
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds. Has lower activity with benzaldehyde [1]. Activity with NAD+ is more than 10-fold higher than with NADP+ [3]. cf. EC 1.2.1.32, aminomuconate-semialdehyde dehydrogenase.
History
EC 1.2.1.85 created 2012
Pathway
ec00362  Benzoate degradation
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10217  aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase
Genes
PGE: LG71_12245
SLQ: M495_05225
PSD: DSC_09155
LAB: LA76x_2548(aldH8A1)
LAQ: GLA29479_1093
LCP: LC55x_2794(aldH8A1)
LGU: LG3211_2666(aldh8a1)
LEZ: GLE_2672
LEM: LEN_2363
LMB: C9I47_1501
DKO: I596_481
PPSE: BN5_3621(xylG)
PCQ: PcP3B5_23470(amnC)
PPI: ND088(nahI)
PKC: PKB_3261(amnc1) PKB_3609(amnc3)
PSOS: POS17_2264
PSET: THL1_493
AVN: Avin_08730(xylG) Avin_30620(lapC)
AVL: AvCA_08730(xylG) AvCA_30620(lapC)
AVD: AvCA6_08730(xylG) AvCA6_30620(lapC)
ACX: Achr_32710(xylG)
SWD: Swoo_1410
MAD: HP15_1111(betB) HP15_4032(betB)
SALH: HMF8227_02739(dmpC)
CYQ: Q91_0507(xylG) Q91_1784(lapC)
APAC: S7S_06985
KKO: Kkor_0387
KGE: TQ33_1983
TBN: TBH_C0927
RSO: RSp0890(dmpC)
RSE: F504_4327
RPI: Rpic_4622
REH: H16_B0547(h16_B0547)
CNC: CNE_2c04930(dmpC) CNE_BB1p12000(dmpC1) CNE_BB1p13290(dmpC2)
RME: Rmet_1322(dmpC) Rmet_5206(amnC)
BCJ: BCAM2132(nbaE)
BCEN: DM39_4835
BCEO: I35_6014(nbaE)
BMUL: NP80_3862
BCT: GEM_5404
BCED: DM42_4994
BCON: NL30_24605
BTEI: WS51_00555
BPSL: WS57_12170
BXE: Bxe_A1147(amnC)
BXB: DR64_3306
BFN: OI25_258
BAV: BAV0552(amnC)
BHZ: ACR54_00824(amnC_1)
AXX: ERS451415_05308(amnC)
PUT: PT7_3613
POL: Bpro_5132
AJS: Ajs_0220
VEI: Veis_2787
MPT: Mpe_A2275
JAG: GJA_237
LCH: Lcho_3354
AZO: azo1852(lapC) azo2435(nahI)
ARC: ABLL_2445
MXA: MXAN_0921
CCX: COCOR_00871(amnC)
BBAC: EP01_17230
ARA: Arad_7263(betB)
MSL: Msil_1476
NAR: Saro_3855
SMAZ: LH19_00745
SGI: SGRAN_3552(amnC)
SWI: Swit_3519
SPHD: HY78_06685
SPKC: KC8_11570
SJP: SJA_C1-11860(hpaE_xylG)
SINB: SIDU_08335
TMO: TMO_b0431(dmpC)
MAGQ: MGMAQ_0648
BLI: BL03906
BLD: BLi03994(dmpC)
BCA: BCE_2154
BCX: BCA_2152
BCF: bcf_10200
BCER: BCK_24235
BTL: BALH_1841
BMYC: DJ92_4635
BMQ: BMQ_3590
BMD: BMD_3575
BMEG: BG04_464
BACO: OXB_2507
BGY: BGLY_4398
GTN: GTNG_3154(nbaE)
GGH: GHH_c14810(dmpC)
BBE: BBR47_29750(dhaS)
ASOC: CB4_02455(xylG)
AAC: Aaci_1622
AAD: TC41_1518(hpaE)
BTS: Btus_0966
TMR: Tmar_1783
SAY: TPY_0646(hpaE)
LPIL: LIP_2170
MIT: OCO_14810
MIA: OCU_15250
MJL: Mjls_4206
NFA: NFA_30520
NFR: ERS450000_01013(xylG)
REY: O5Y_02260
REQ: REQ_05040(amnC)
RRT: 4535765_01258(amnC_1) 4535765_01264(amnC_2)
GBR: Gbro_0237
SCB: SCAB_15221(amnC)
SBH: SBI_01538
KFL: Kfla_5493
TCU: Tcur_0539
SRO: Sros_9116
PDX: Psed_2510
ALL: CRK56596
SAQ: Sare_3903
MIL: ML5_3354
RCA: Rcas_2406
CAU: Caur_1356
CAG: Cagg_2038
TTJ: TTHB240
GES: VT84_03880(amnC)
HSW: Hsw_0099
DDO: I597_1376(amnC)
NDO: DDD_2048
WIN: WPG_2044
TJE: TJEJU_1410(dmpC)
TMAR: MARIT_1046(dmpC)
KOS: KORDIASMS9_02221(amnC)
MARF: CJ739_785
 » show all
Taxonomy
Reference
1  [PMID:7868591]
  Authors
Inoue J, Shaw JP, Rekik M, Harayama S
  Title
Overlapping substrate specificities of benzaldehyde dehydrogenase (the xylC gene  product) and 2-hydroxymuconic semialdehyde dehydrogenase (the xylG gene product)  encoded by TOL plasmid pWW0 of Pseudomonas putida.
  Journal
J Bacteriol 177:1196-201 (1995)
DOI:10.1128/JB.177.5.1196-1201.1995
  Sequence
Reference
2  [PMID:17090920]
  Authors
Orii C, Takenaka S, Murakami S, Aoki K
  Title
Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain 10d: A different modified meta-cleavage pathway for 2-aminophenols.
  Journal
Biosci Biotechnol Biochem 70:2653-61 (2006)
DOI:10.1271/bbb.60264
Reference
3  [PMID:19717587]
  Authors
Kasai D, Fujinami T, Abe T, Mase K, Katayama Y, Fukuda M, Masai E
  Title
Uncovering the protocatechuate 2,3-cleavage pathway genes.
  Journal
J Bacteriol 191:6758-68 (2009)
DOI:10.1128/JB.00840-09
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.85
IUBMB Enzyme Nomenclature: 1.2.1.85
ExPASy - ENZYME nomenclature database: 1.2.1.85
BRENDA, the Enzyme Database: 1.2.1.85

DBGET integrated database retrieval system