KEGG   ENZYME: 1.2.7.6Help
Entry
EC 1.2.7.6                  Enzyme                                 

Name
glyceraldehyde-3-phosphate dehydrogenase (ferredoxin);
GAPOR;
glyceraldehyde-3-phosphate Fd oxidoreductase;
glyceraldehyde-3-phosphate ferredoxin reductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase
Reaction(IUBMB)
D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin [RN:R07159]
Reaction(KEGG)
Substrate
D-glyceraldehyde-3-phosphate;
H2O [CPD:C00001];
oxidized ferredoxin [CPD:C00139]
Product
3-phospho-D-glycerate [CPD:C00197];
H+ [CPD:C00080];
reduced ferredoxin [CPD:C00138]
Comment
Contains tungsten-molybdopterin and iron-sulfur clusters. This enzyme is thought to function in place of glyceralde-3-phosphate dehydrogenase and possibly phosphoglycerate kinase in the novel Embden-Meyerhof-type glycolytic pathway found in Pyrococcus furiosus [1]. It is specific for glyceraldehyde-3-phosphate.
History
EC 1.2.7.6 created 2003
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K11389  glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)
Genes
GUR: Gura_2648
GSB: GSUB_04300
DOL: Dole_2101
ATM: ANT_14840
TAM: Theam_0376
TOP: TOPB45_0887
TCM: HL41_05125
MJA: MJ_1185
MFE: Mefer_0232
MVU: Metvu_1517
MMP: MMP0945
MMD: GYY_05445
MAE: Maeo_0444
MVO: Mvol_0992
PHO: PH0457(PH0457)
PAB: PAB1315
PFU: PF0464
PFI: PFC_01435
PYN: PNA2_1087
PYS: Py04_0640
TKO: TK2163
TON: TON_1498
TGA: TGAM_0122(gor)
TSI: TSIB_1686
THE: GQS_07935
THA: TAM4_1410
THM: CL1_1206
TLT: OCC_05826
THS: TES1_1819
TNU: BD01_1964
TEU: TEU_01570
PPAC: PAP_09975
SMR: Smar_1582
IHO: Igni_0296
IIS: EYM_02335
DKA: DKAM_0499
TAG: Tagg_0452
IAG: Igag_1482
PAI: PAE1029
PIS: Pisl_1226
PCL: Pcal_0664
PAS: Pars_0189
PYR: P186_2447
POG: Pogu_2290
TNE: Tneu_0174
CMA: Cmaq_0263
TUZ: TUZN_1446
TTN: TTX_2037(gor)
VDI: Vdis_2526
VMO: VMUT_0871
ASC: ASAC_0245
ACIA: SE86_02005
NAA: Nps_00740
 » show all
Taxonomy
Reference
1  [PMID:7721730]
  Authors
Mukund S, Adams MW.
  Title
Glyceraldehyde-3-phosphate ferredoxin oxidoreductase, a novel tungsten-containing enzyme with a potential glycolytic role in the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J Biol Chem 270:8389-92 (1995)
DOI:10.1074/jbc.270.15.8389
  Sequence
[pfu:PF0464]
Reference
2  [PMID:11265456]
  Authors
Roy R, Menon AL, Adams MW.
  Title
Aldehyde oxidoreductases from Pyrococcus furiosus.
  Journal
Methods Enzymol 331:132-44 (2001)
DOI:10.1016/S0076-6879(01)31052-2
  Sequence
[pfu:PF0464]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.7.6
IUBMB Enzyme Nomenclature: 1.2.7.6
ExPASy - ENZYME nomenclature database: 1.2.7.6
BRENDA, the Enzyme Database: 1.2.7.6
CAS: 162995-20-2

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