KEGG   ENZYME: 1.2.7.8Help
Entry
EC 1.2.7.8                  Enzyme                                 

Name
indolepyruvate ferredoxin oxidoreductase;
3-(indol-3-yl)pyruvate synthase (ferredoxin);
IOR
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)
Reaction(IUBMB)
(indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + H+ [RN:R07161]
Reaction(KEGG)
Substrate
(indol-3-yl)pyruvate [CPD:C00331];
CoA [CPD:C00010];
oxidized ferredoxin [CPD:C00139]
Product
S-2-(indol-3-yl)acetyl-CoA [CPD:C15489];
CO2 [CPD:C00011];
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Comment
Contains thiamine diphosphate and [4Fe-4S] clusters. Preferentially utilizes the transaminated forms of aromatic amino acids and can use phenylpyruvate and p-hydroxyphenylpyruvate as substrates. This enzyme, which is found in archaea, is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).
History
EC 1.2.7.8 created 2003
Orthology
K00179  indolepyruvate ferredoxin oxidoreductase, alpha subunit
K00180  indolepyruvate ferredoxin oxidoreductase, beta subunit
K04090  indolepyruvate ferredoxin oxidoreductase
Genes
EBT: EBL_c27890 EBL_c27900
PAY: PAU_02252
XBO: XBJ1_0312
XBV: XBW1_4475
XNE: XNC1_0438
XNM: XNC2_0429
XDO: XDD1_0407 XDD1_0579 XDD1_0580
XPO: XPG1_3442
XHO: A9255_13150 A9255_13155 A9255_13950
PRG: RB151_004950 RB151_004960
XCC: XCC0170(iorA)
XCB: XC_0179
XCP: XCR_4362
XCV: XCV0172
XAX: XACM_0173
XAC: XAC0189(iorA)
XCI: XCAW_00585(iorA)
XOO: XOO4505(iorA)
XOM: XOO4244(XOO4244)
XOP: PXO_03584
XOR: XOC_0276
XAL: XALC_3102
XPH: XppCFBP6546_10990(XppCFBP6546P_10990)
SML: Smlt0136
SMT: Smal_0095
SMZ: SMD_0088
PSUW: WQ53_07510
LEZ: GLE_5200
LEM: LEN_0119
DKO: I596_2288
PMY: Pmen_2876
PMK: MDS_1782
PPSE: BN5_2689(iorA1)
PSB: Psyr_3021
PSYR: N018_11435
PSA: PST_0866
PSTT: CH92_04025
PSES: PSCI_1264
PSET: THL1_4273
ABY: ABAYE2294
ABN: AB57_1595
ABX: ABK1_1852
ABH: M3Q_1761
ABAD: ABD1_13670
ABAZ: P795_10380
ABAU: IX87_03440
ABAA: IX88_08785
ACC: BDGL_000745(iorA)
CPS: CPS_2079
MAD: HP15_859
CYQ: Q91_1345
PSE: NH8B_4069
RSE: F504_1560(iorA) F504_1561(iorB_II) F504_3144
RPI: Rpic_3404
REH: H16_A1255(h16_A1255) H16_A3547(porG) H16_B1980(h16_B1980)
RME: Rmet_3396(porG)
BMA: BMA2584
BMAL: DM55_1344
BMAE: DM78_3042
BMAQ: DM76_1320 DM76_1321(porG)
BMAI: DM57_1355
BMAF: DM51_2220
BMAZ: BM44_2995
BMAB: BM45_192
BPAR: BN117_4053
BPT: Bpet0498(iorA1) Bpet0584(iorA2)
ODI: ODI_R4053
RFR: Rfer_3868
PNA: Pnap_3887
AAV: Aave_4646
AJS: Ajs_4008
DAC: Daci_0840
CBAA: SRAA_0168
CBAB: SMCB_1957
MPT: Mpe_A3502
CFU: CFU_4018
CARE: LT85_4571
LCH: Lcho_3905
TIN: Tint_3138
THI: THI_3752
RGE: RGE_02820
EBA: ebA121(iorB) ebA122(iorA)
AZA: AZKH_1453(ifoA_iorA) AZKH_1454(ifoB_iorB) AZKH_1872(ifoA_iorA) AZKH_1873(ifoB_iorB) AZKH_1886(ifoB_iorB) AZKH_1887(ifoA_iorA) AZKH_3649(ifoAB_iorAB) AZKH_4019(ifoAB_iorAB)
SMUL: SMUL_1376(iorB) SMUL_1377(iorA)
GSU: GSU1738(iorB-1) GSU1739(iorA-1) GSU2052(iorB-2) GSU2053(iorA-2)
GSK: KN400_1763(iorB-1) KN400_1764(iorA-1) KN400_2074(iorB-2) KN400_2075(iorA-2)
GME: Gmet_0948(iorA-2) Gmet_0949(iorB-2) Gmet_1826(iorB-1) Gmet_1827(iorA-1)
GBM: Gbem_1419(iorA-2) Gbem_1420(iorB-2) Gbem_2193(iorB-1) Gbem_2194(iorA-1)
GEO: Geob_0159(iorB-3) Geob_0160(iorA-3) Geob_1060(iorA-2) Geob_1061(iorB-2) Geob_2794(iorA-1) Geob_2795(iorB-1)
PCA: Pcar_1567(iorA-1) Pcar_1568(iorB-1) Pcar_2116(iorB-2) Pcar_2117(iorA-2)
DES: DSOUD_1895(iorB) DSOUD_1896(iorA)
DDE: Dde_0467
DMA: DMR_26670(iorA) DMR_26680(iorB)
DHY: DESAM_10094(iorB) DESAM_10095(iorA)
DGG: DGI_0081 DGI_0082(iorA)
DPI: BN4_10975(iorA) BN4_10976
PPRF: DPRO_3006 DPRO_3007(iorA)
DML: Dmul_01260(iorB1) Dmul_01270(iorA1) Dmul_11800(iorA2) Dmul_11810(iorB2) Dmul_24890(iorB3) Dmul_24900(iorA3)
DAT: HRM2_11230(iorA1) HRM2_11240(iorB1) HRM2_21470(iorA2) HRM2_21480(iorB2) HRM2_33520(iorB3) HRM2_40780(iorB4) HRM2_40790(iorA4)
DTO: TOL2_C02870(iorA) TOL2_C02880(iorB) TOL2_C17570(iorB2) TOL2_C17580(iorA2) TOL2_C28230 TOL2_C28240(iorA3) TOL2_C37160(iorB3) TOL2_C37170(iorA4)
BMX: BMS_1998
MES: Meso_2811
RLE: pRL120179
SHZ: shn_01080
BRA: BRADO4317
AOL: S58_30590
RPA: RPA1224(iorA) RPA1225 RPA3195
NWI: Nwi_1745
NHA: Nham_2178
XAU: Xaut_0390
AZC: AZC_0699
MET: M446_2324
MNO: Mnod_0287
BID: Bind_0083
MSL: Msil_1152
RVA: Rvan_0697
MSC: BN69_2840
CCR: CC_3176
CAK: Caul_0820
CSE: Cseg_0783
RSP: RSP_2948
RDE: RD1_3230
DSH: Dshi_1762
OTM: OSB_16790
MALG: MALG_01935
RSU: NHU_02439
HNE: HNE_3070
SMAZ: LH19_27455
SGI: SGRAN_0814(iorB) SGRAN_0815(iorA)
SPMI: K663_03460
SPHT: K426_00710
ACR: Acry_2438
RCE: RC1_3164
AZL: AZL_017580(iorA)
TMO: TMO_0546(iorA) TMO_c0303
TXI: TH3_07020
MAGQ: MGMAQ_3117(iorB) MGMAQ_3118(iorA)
MAI: MICA_892
MAN: A11S_808
CAC: CA_C2000(iorB) CA_C2001(iorA)
CAE: SMB_G2032(iorB) SMB_G2033(iorA)
CAY: CEA_G2015(iorB) CEA_G2016(iorA)
CACE: CACET_c11800(iorA) CACET_c11810(iorB)
CSS: Cst_c07940(iorA) Cst_c07950(iorB)
RUS: RBI_II00504(iorA) RBI_II00505(iorB)
BPB: bpr_I1502(iorA) bpr_I1503(iorB)
CPRO: CPRO_15880 CPRO_15890(ndhI_2)
CDF: CD630_23800(iorB) CD630_23810(iorA)
PDC: CDIF630_02620(iorB) CDIF630_02621(iorA)
CDC: CD196_2221(iorB) CD196_2222(iorA)
CDL: CDR20291_2267(iorB) CDR20291_2268(iorA)
DED: DHBDCA_p247(iorB) DHBDCA_p248(iorA) DHBDCA_p654(iorB) DHBDCA_p655(iorA)
DEC: DCF50_p307(iorB) DCF50_p308(iorA) DCF50_p712(iorB) DCF50_p713(iorA)
HMO: HM1_0481(oorB) HM1_0482(oorA) HM1_1466(oorA) HM1_1467(oorB)
AWO: Awo_c19630(iorA) Awo_c19640(iorB)
TTE: TTE2193(PorG3) TTE2194(PorA5)
TKI: TKV_c19230(iorB) TKV_c19240(iorA)
CHY: CHY_0121(iorA) CHY_0122(iorB)
TAE: TepiRe1_0074(iorA) TepiRe1_0075(iorB) TepiRe1_2397(iorB) TepiRe1_2398(iorA)
TPZ: Tph_c04800(iorA1) Tph_c04810(iorB1) Tph_c23780(iorB2) Tph_c23790(iorA2)
MED: MELS_0438
MIT: OCO_14640
MIA: OCU_15080
MMC: Mmcs_5425
MKM: Mkms_6009
MJL: Mjls_4222
MGI: Mflv_4433
MAB: MAB_4356c
CJK: jk0975
CRD: CRES_1055
RER: RER_47310
REY: O5Y_22355
ROP: ROP_13260
GBR: Gbro_1356
TPR: Tpau_1784
SMAL: SMALA_1095
NCA: Noca_1835
SRO: Sros_3354
SEN: SACE_4073
AMD: AMED_5858
AMN: RAM_30055
AMM: AMES_5779
AMZ: B737_5779
AOI: AORI_4791
PSEE: FRP1_17055
SESP: BN6_58310
KAL: KALB_3136
DET: DET0947(iorA) DET0948(iorB)
DEH: cbdbA902(iorA) cbdbA903(iorB)
DEV: DhcVS_818(iorA) DhcVS_819(iorB)
DMC: btf_843(iorA) btf_844(iorB)
DMD: dcmb_881(iorA) dcmb_882(iorB)
DMG: GY50_0826(iorA) GY50_0827(iorB)
DUC: UCH007_07790(iorA) UCH007_07800(iorB)
DEW: DGWBC_0992(lorA) DGWBC_0993(lorB)
DFO: Dform_01308(iorA) Dform_01309(iorB)
ATM: ANT_15580(iorB) ANT_15590(iorA)
MIN: Minf_1239
EPO: Epro_1115(iorA) Epro_1116
FSC: FSU_1704
PGI: PG_0674(iorB) PG_0675(iorA)
PMUC: ING2E5A_2685(iorB) ING2E5A_2686(iorA)
ASH: AL1_24800
IAL: IALB_2768(iorA) IALB_2769(iorB)
CACI: CLOAM1037(iorB) CLOAM1038(iorA)
TAF: THA_952(iorB) THA_953(iorA)
CEX: CSE_00170(iorA) CSE_15550(iorB)
MMP: MMP0315(iorB1) MMP0316(iorA1) MMP0713(iorA2) MMP0714(iorB2)
MMG: MTBMA_c04220(iorA) MTBMA_c04230(iorB)
MWO: MWSIV6_0382(iorA) MWSIV6_0383(iorB)
MST: Msp_1042(iorB) Msp_1043(iorA)
MRU: mru_0656(iorA) mru_0657(iorB)
MEB: Abm4_1338(iorB) Abm4_1339(iorA)
MMIL: sm9_0613(iorA) sm9_0614(iorB)
METH: MBMB1_1316(iorB) MBMB1_1317(iorA)
MFC: BRM9_0538(iorB) BRM9_0539(iorA)
MFI: DSM1535_0519(iorB) DSM1535_0520(iorA)
MCUB: MCBB_1551(iorB) MCBB_1552(iorA)
TVO: TVG0563052(TVG0563052) TVG0563624(TVG0563624)
MEAR: Mpt1_c05230(iorA1) Mpt1_c05240(iorB)
PHO: PH0229(PH0229) PH0764(PH0764) PH0765(PH0765) PH1138(PH1138)
PAB: PAB0143(iorB-2) PAB0718(iorA-2) PAB0855(iorA-1) PAB0857(iorB-1)
TGA: TGAM_0427(iorA-1) TGAM_0428(iorB-1) TGAM_1129(iorA-2) TGAM_2042(iorB-2)
MAC: MA_1022 MA_1023 MA_1726(iorB) MA_1727(iorA) MA_1982(ior)
MCJ: MCON_1110(iorA) MCON_1111(iorB) MCON_1345(iorA) MCON_1346(iorB) MCON_3168
MBG: BN140_0858(iorB) BN140_0859(iorA)
MEMA: MMAB1_1127(iorB) MMAB1_1128(iorA)
MPD: MCP_1187(iorA) MCP_1188(iorB) MCP_1959
MEZ: Mtc_1561 Mtc_2053(iorA) Mtc_2054(iorB)
RCI: RCIX2649(iorA-2) RRC396(iorB) RRC398(iorA-1)
STO: STK_07320(iorA) STK_07340(iorB)
SSO: SSO2067(iorA) SSO2069(iorB)
SAI: Saci_2228(iorB) Saci_2229(iorA)
TTN: TTX_0712(iorA) TTX_0713(iorB)
BARC: AOA65_1263(iorB) AOA65_1264(iorA)
LOKI: Lokiarch_10890(iorA_1) Lokiarch_10910(iorB_1) Lokiarch_30840(iorB_2) Lokiarch_30850(iorA_2) Lokiarch_42200(iorA_3) Lokiarch_42210(iorB_3)
 » show all
Taxonomy
Reference
1  [PMID:8206994]
  Authors
Mai X, Adams MW.
  Title
Indolepyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus. A new enzyme involved in peptide fermentation.
  Journal
J Biol Chem 269:16726-32 (1994)
Reference
2  [PMID:9180697]
  Authors
Siddiqui MA, Fujiwara S, Imanaka T.
  Title
Indolepyruvate ferredoxin oxidoreductase from Pyrococcus sp. KOD1 possesses a mosaic structure showing features of various oxidoreductases.
  Journal
Mol Gen Genet 254:433-9 (1997)
  Sequence
Reference
3  [PMID:9108258]
  Authors
Tersteegen A, Linder D, Thauer RK, Hedderich R.
  Title
Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum.
  Journal
Eur J Biochem 244:862-8 (1997)
DOI:10.1111/j.1432-1033.1997.00862.x
  Sequence
Reference
4  [PMID:11265457]
  Authors
Schut GJ, Menon AL, Adams MW.
  Title
2-keto acid oxidoreductases from Pyrococcus furiosus and Thermococcus litoralis.
  Journal
Methods Enzymol 331:144-58 (2001)
DOI:10.1016/S0076-6879(01)31053-4
Other DBs
ExplorEnz - The Enzyme Database: 1.2.7.8
IUBMB Enzyme Nomenclature: 1.2.7.8
ExPASy - ENZYME nomenclature database: 1.2.7.8
BRENDA, the Enzyme Database: 1.2.7.8
CAS: 158886-06-7

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