KEGG   ENZYME: 1.2.98.1Help
Entry
EC 1.2.98.1                 Enzyme                                 

Name
formaldehyde dismutase;
aldehyde dismutase;
cannizzanase;
nicotinoprotein aldehyde dismutase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors
BRITE hierarchy
Sysname
formaldehyde:formaldehyde oxidoreductase
Reaction(IUBMB)
2 formaldehyde + H2O = formate + methanol [RN:R00614]
Reaction(KEGG)
Substrate
formaldehyde [CPD:C00067];
H2O [CPD:C00001]
Product
formate [CPD:C00058];
methanol [CPD:C00132]
Comment
The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP+ by reaction with a second formaldehyde, yielding methanol. The enzyme from the bacterium Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, alcohol dehydrogenase (nicotinoprotein) and EC 1.1.99.37, methanol dehydrogenase (nicotinoprotein) [3]. Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors [1,2].
History
EC 1.2.98.1 created 1986 as EC 1.2.99.4, modified 2012, transferred 2015 to EC 1.2.98.1
Pathway
ec00625  Chloroalkane and chloroalkene degradation
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K17067  formaldehyde dismutase / methanol dehydrogenase
K17068  formaldehyde dismutase
Genes
GUR: Gura_3568
GEB: GM18_3226
GPI: GPICK_06680
DAE: Dtox_4270
MYN: MyAD_25070
MDX: BTO20_03135 BTO20_38200
MSM: MSMEG_6242
MSG: MSMEI_6081
MSB: LJ00_30865
MSN: LI99_30870
MVA: Mvan_5479
ASD: AS9A_4308
NFA: NFA_22240
NFR: ERS450000_01873(thcE)
RER: RER_17770
REY: O5Y_08520
ROP: ROP_61160
RHB: NY08_1972
RRZ: CS378_08140(mdo)
RQI: C1M55_08995(mdo)
RRT: 4535765_03582(thcE)
GBR: Gbro_1931
GOR: KTR9_1872
GOC: CXX93_15365(mdo)
GIT: C6V83_07720(mdo)
GRU: GCWB2_09440(thcE)
GOM: D7316_01326(mno) D7316_03687(thcE)
DIZ: CT688_01100(mdo)
SHY: SHJG_2446
NML: Namu_0777
SEN: SACE_2386
AMQ: AMETH_5577(mdo)
PSEA: WY02_13685
PSEH: XF36_28100
 » show all
Taxonomy
Reference
1
  Authors
Kato, N., Shirakawa, K., Kobayashi, H. and Sakazawa, C.
  Title
The dismutation of aldehydes by a bacterial enzyme.
  Journal
Agric Biol Chem 47:39-46 (1983)
Reference
2  [PMID:3514215]
  Authors
Kato N, Yamagami T, Shimao M, Sakazawa C
  Title
Formaldehyde dismutase, a novel NAD-binding oxidoreductase from Pseudomonas putida F61.
  Journal
Eur J Biochem 156:59-64 (1986)
DOI:10.1111/j.1432-1033.1986.tb09548.x
  Sequence
Reference
3  [PMID:19875438]
  Authors
Park H, Lee H, Ro YT, Kim YM
  Title
Identification and functional characterization of a gene for the methanol : N,N'-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803).
  Journal
Microbiology 156:463-71 (2010)
DOI:10.1099/mic.0.034124-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.98.1
IUBMB Enzyme Nomenclature: 1.2.98.1
ExPASy - ENZYME nomenclature database: 1.2.98.1
BRENDA, the Enzyme Database: 1.2.98.1
CAS: 85204-94-0

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