KEGG   ENZYME: 1.2.99.7Help
Entry
EC 1.2.99.7                 Enzyme                                 

Name
aldehyde dehydrogenase (FAD-independent);
aldehyde oxidase;
aldehyde oxidoreductase;
Mop;
AORDd
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
aldehyde:acceptor oxidoreductase (FAD-independent)
Reaction(IUBMB)
an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor [RN:R00544]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
H2O [CPD:C00001];
acceptor [CPD:C00028]
Product
carboxylate [CPD:C00060];
reduced acceptor [CPD:C00030]
Comment
Belongs to the xanthine oxidase family of enzymes. The enzyme from Desulfovibrio sp. contains a molybdenum-molybdopterin-cytosine dinucleotide (MCD) complex and two types of [2Fe-2S] cluster per monomer, but does not contain FAD.
History
EC 1.2.99.7 created 2004
Orthology
K07469  aldehyde oxidoreductase
Genes
SDL: Sdel_1475
SMUL: SMUL_2101
SHAL: SHALO_1855
SULS: Sdiek1_1939
SULJ: SJPD1_1855
GUR: Gura_0998
PCA: Pcar_0220
PPD: Ppro_1551
PACE: A6070_10775 A6070_14425
PEF: A7E78_09400
DVU: DVU1559(mop)
DVL: Dvul_1574
DVM: DvMF_0641
DDE: Dde_3539
DDS: Ddes_1823
DMA: DMR_05980
DHY: DESAM_20433(mop)
DGG: DGI_0902(mop)
DPI: BN4_11879(mop)
PPRF: DPRO_1126(mop)
DBA: Dbac_1562
DRT: Dret_1808
DPS: DP0270
DAT: HRM2_07080(mop1) HRM2_38770(mop2)
DTO: TOL2_C39330(mop)
SFU: Sfum_1310
CLS: CXIVA_04850(CoxL)
CSR: Cspa_c06890(mop1)
CSQ: CSCA_3243
CTYK: CTK_C17200
RUM: CK1_27440
ROB: CK5_22910
DHD: Dhaf_3146
DAE: Dtox_3440
PTH: PTH_0679
AWO: Awo_c03890(mop1) Awo_c14980(mop3) Awo_c27190
OVA: OBV_43650(mop)
PFT: JBW_01067
 » show all
Taxonomy
Reference
1  [PMID:14659539]
  Authors
Uchida H, Kondo D, Yamashita A, Nagaosa Y, Sakurai T, Fujii Y, Fujishiro K, Aisaka K, Uwajima T.
  Title
Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690.
  Journal
FEMS Microbiol Lett 229:31-6 (2003)
DOI:10.1016/S0378-1097(03)00781-X
Reference
2  [PMID:10679276]
  Authors
Duarte RO, Archer M, Dias JM, Bursakov S, Huber R, Moura I, Romao MJ, Moura JJ.
  Title
Biochemical/spectroscopic characterization and preliminary X-ray analysis of a new aldehyde oxidoreductase isolated from Desulfovibrio desulfuricans ATCC 27774.
  Journal
Biochem Biophys Res Commun 268:745-9 (2000)
DOI:10.1006/bbrc.2000.2135
Reference
3  [PMID:10727945]
  Authors
Andrade SL, Brondino CD, Feio MJ, Moura I, Moura JJ.
  Title
Aldehyde oxidoreductase activity in Desulfovibrio alaskensis NCIMB 13491 EPR assignment of the proximal [2Fe-2S] cluster to the Mo site.
  Journal
Eur J Biochem 267:2054-61 (2000)
DOI:10.1046/j.1432-1327.2000.01209.x
Reference
4  [PMID:7502041]
  Authors
Romao MJ, Archer M, Moura I, Moura JJ, LeGall J, Engh R, Schneider M, Hof P, Huber R.
  Title
Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas.
  Journal
Science 270:1170-6 (1995)
DOI:10.1126/science.270.5239.1170
  Sequence
[dgg:DGI_0902]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.99.7
IUBMB Enzyme Nomenclature: 1.2.99.7
ExPASy - ENZYME nomenclature database: 1.2.99.7
BRENDA, the Enzyme Database: 1.2.99.7

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