KEGG   ENZYME: 1.21.1.1Help
Entry
EC 1.21.1.1                 Enzyme                                 

Name
iodotyrosine deiodinase;
iodotyrosine dehalogenase 1;
DEHAL1
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y
BRITE hierarchy
Sysname
L-tyrosine,iodide:NADP+ oxidoreductase (iodinating)
Reaction(IUBMB)
L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ (overall reaction) [RN:R10059];
(1a) L-tyrosine + NADP+ + iodide = 3-iodo-L-tyrosine + NADPH + H+ [RN:R09521];
(1b) 3-iodo-L-tyrosine + NADP+ + iodide = 3,5-diiodo-L-tyrosine + NADPH + H+ [RN:R09522]
Reaction(KEGG)
Substrate
L-tyrosine [CPD:C00082];
NADP+ [CPD:C00006];
iodide [CPD:C00708];
3-iodo-L-tyrosine [CPD:C02515]
Product
3,5-diiodo-L-tyrosine [CPD:C01060];
NADPH [CPD:C00005];
H+ [CPD:C00080];
3-iodo-L-tyrosine [CPD:C02515]
Comment
The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.
History
EC 1.21.1.1 created 2010 as EC 1.22.1.1 transfered 2015 to EC 1.21.1.1
Orthology
K17231  iodotyrosine deiodinase
Genes
HSA: 389434(IYD)
PTR: 472159(IYD)
PPS: 100984862(IYD)
GGO: 101134826(IYD)
PON: 100127058(IYD)
NLE: 100604496(IYD)
MCC: 705471(IYD)
MCF: 102137987(IYD)
CSAB: 103240719(IYD)
RRO: 104678344(IYD)
RBB: 108539141(IYD)
CJC: 100414973(IYD)
SBQ: 101036070(IYD)
MMU: 70337(Iyd)
RNO: 308129(Iyd)
CGE: 100766759(Iyd)
NGI: 103745746(Iyd)
HGL: 101721889(Iyd)
CCAN: 109694205(Iyd)
OCU: 100353029(IYD)
TUP: 102468639(IYD)
CFA: 476244(IYD)
AML: 100476845(IYD)
UMR: 103666913(IYD)
ORO: 101373266(IYD)
FCA: 101100136(IYD)
PTG: 102961413(IYD)
AJU: 106976275(IYD)
BTA: 534110(IYD)
BOM: 102270351(IYD)
BIU: 109564048(IYD)
PHD: 102340056(IYD)
CHX: 102171610(IYD)
OAS: 101123564(IYD)
SSC: 403124(IYD)
CFR: 102518380(IYD)
CDK: 105100920(IYD)
BACU: 103018668(IYD)
LVE: 103070559(IYD)
OOR: 101281121(IYD)
ECB: 100147582(IYD)
EPZ: 103548978(IYD)
EAI: 106837202(IYD)
MYB: 102251589(IYD)
MYD: 102768666(IYD)
HAI: 109380862(IYD)
RSS: 109449307(IYD)
PALE: 102879253(IYD)
LAV: 100655124(IYD)
TMU: 101346269
MDO: 100032091(IYD)
SHR: 100913424(IYD)
OAA: 100074313(IYD)
GGA: 421631(IYD)
MGP: 100542007(IYD)
CJO: 107311580(IYD)
APLA: 101792350(IYD)
ACYG: 106034300(IYD)
TGU: 100219876(IYD)
GFR: 102034470(IYD)
FAB: 101817326(IYD)
PHI: 102107342(IYD)
PMAJ: 107202547(IYD)
CCAE: 111926697(IYD)
CCW: 104690271(IYD)
FPG: 101919057(IYD)
FCH: 102046732(IYD)
CLV: 102093624(IYD)
EGZ: 104133538(IYD)
AAM: 106496910(IYD)
ASN: 102382246(IYD)
AMJ: 102570232(IYD)
PSS: 102454348(IYD)
CMY: 102935978(IYD)
CPIC: 101948894(IYD)
ACS: 100566819(iyd)
PVT: 110086269(IYD)
PBI: 103056683(IYD)
GJA: 107109504(IYD)
XLA: 447152(iyd.L)
XTR: 496718(iyd)
NPR: 108797441(IYD)
DRE: 100330940(si:ch211-286f9.2)
SANH: 107697889
SGH: 107558720 107590463(iyd)
CCAR: 109057743(iyd) 109060687
IPU: 108275850(iyd)
AMEX: 103036643(iyd)
TRU: 101074588(iyd)
LCO: 104923576(iyd) 109141009
NCC: 104950033(iyd)
MZE: 101464367(iyd)
OLA: 111947100(iyd)
XMA: 102217045(iyd)
PRET: 103457674(iyd)
NFU: 107395153(iyd)
KMR: 108242444(iyd)
CSEM: 103381076(iyd)
LCF: 108896829(iyd)
SDU: 111216311(iyd)
HCQ: 109531800(iyd)
BPEC: 110156123(iyd)
MALB: 109973854(iyd)
SASA: 106608372(iyd)
OTW: 112237839(iyd)
ELS: 105017989(iyd)
SFM: 108920896(iyd)
LCM: 102346446(IYD)
CMK: 103179239(iyd)
SPU: 592720
SKO: 100378150
DME: Dmel_CG6279(Iyd)
DSI: Dsimw501_GD12829(Dsim_GD12829)
MDE: 101888214
AAG: 5572342
AME: 413740
BIM: 100748968
BTER: 100647581
SOC: 105195062
AEC: 105146911
ACEP: 105623675
PBAR: 105429559
HST: 105189951
DQU: 106750633
CFO: 105256572
LHU: 105676104
PGC: 109857517
PCF: 106789438
NVI: 100122307
MDL: 103576191
TCA: 654861
NVL: 108559097
BMOR: 101741567
PMAC: 106711132
PRAP: 110992079
HAW: 110382329
PXY: 105389069
CLEC: 106666802
ZNE: 110839726
FCD: 110843860
CEL: CELE_C02C2.5(sup-18)
BMY: Bm1_39515
OBI: 106878694
ADF: 107343804
HMG: 100199794
AQU: 105316407
 » show all
Taxonomy
Reference
1  [PMID:4394169]
  Authors
Rosenberg IN
  Title
Purification of iodotyrosine deiodinase from bovine thyroid.
  Journal
Metabolism 19:785-98 (1970)
DOI:10.1016/0026-0495(70)90076-4
Reference
2  [PMID:15289438]
  Authors
Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noel-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C
  Title
Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site.
  Journal
FASEB J 18:1574-6 (2004)
DOI:10.1096/fj.04-2023fje
  Sequence
[hsa:389434] [ssc:403124]
Reference
3  [PMID:16316988]
  Authors
Friedman JE, Watson JA Jr, Lam DW, Rokita SE
  Title
Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin  reductase superfamily.
  Journal
J Biol Chem 281:2812-9 (2006)
DOI:10.1074/jbc.M510365200
Reference
4  [PMID:19436071]
  Authors
Thomas SR, McTamney PM, Adler JM, Laronde-Leblanc N, Rokita SE
  Title
Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands.
  Journal
J Biol Chem 284:19659-67 (2009)
DOI:10.1074/jbc.M109.013458
  Sequence
[mmu:70337]
Other DBs
ExplorEnz - The Enzyme Database: 1.21.1.1
IUBMB Enzyme Nomenclature: 1.21.1.1
ExPASy - ENZYME nomenclature database: 1.21.1.1
BRENDA, the Enzyme Database: 1.21.1.1

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