KEGG   ENZYME: 1.21.1.2Help
Entry
EC 1.21.1.2                 Enzyme                                 

Name
2,4-dichlorobenzoyl-CoA reductase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y
BRITE hierarchy
Sysname
4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)
Reaction(IUBMB)
4-chlorobenzoyl-CoA + NADP+ + chloride = 2,4-dichlorobenzoyl-CoA + NADPH + H+ [RN:R05276]
Reaction(KEGG)
Substrate
4-chlorobenzoyl-CoA [CPD:C06387];
NADP+ [CPD:C00006];
chloride [CPD:C00698]
Product
2,4-dichlorobenzoyl-CoA [CPD:C06671];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from Corynebacterium strains able to grow on 2,4-dichlorobenzoate, forms part of the 2,4-dichlorobenzoate degradation pathway.
History
EC 1.21.1.2 created 2000 as EC 1.3.1.63, modified 2011, transferred 2015 to EC 1.21.1.2
Pathway
ec00364  Fluorobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:8626335]
  Authors
Romanov V, Hausinger RP.
  Title
NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform bacterium strainNTB-1 via 2,4-dichlorobenzoyl coenzyme A.
  Journal
J Bacteriol 178:2656-61 (1996)
DOI:10.1128/JB.178.9.2656-2661.1996
Other DBs
ExplorEnz - The Enzyme Database: 1.21.1.2
IUBMB Enzyme Nomenclature: 1.21.1.2
ExPASy - ENZYME nomenclature database: 1.21.1.2
BRENDA, the Enzyme Database: 1.21.1.2

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