KEGG   ENZYME: 1.21.99.1Help
Entry
EC 1.21.99.1                Enzyme                                 

Name
beta-cyclopiazonate dehydrogenase;
beta-cyclopiazonate oxidocyclase;
beta-cyclopiazonic oxidocyclase;
beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With unknown physiological acceptors
BRITE hierarchy
Sysname
beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)
Reaction(IUBMB)
beta-cyclopiazonate + acceptor = alpha-cyclopiazonate + reduced acceptor [RN:R04080]
Reaction(KEGG)
Substrate
beta-cyclopiazonate [CPD:C02899];
acceptor [CPD:C00028]
Product
alpha-cyclopiazonate [CPD:C03032];
reduced acceptor [CPD:C00030]
Comment
A flavoprotein (FAD). Cytochrome c and various dyes can act as acceptor. Cyclopiazonate is a microbial toxin.
History
EC 1.21.99.1 created 1976 as EC 1.3.99.9, transferred 2002 to EC 1.21.99.1
Orthology
K15393  beta-cyclopiazonate dehydrogenase
Genes
AOR: AO090026000003
AFV: AFLA_139470
Taxonomy
Reference
1  [PMID:8076]
  Authors
Edmondson DE, Kenney WC, Singer TP.
  Title
Structural elucidation and properties of 8alpha-(N1-histidyl)riboflavin: the flavin component of thiamine dehydrogenase and beta-cyclopiazonate oxidocyclase.
  Journal
Biochemistry 15:2937-45 (1976)
Reference
2  [PMID:5143340]
  Authors
Schabort JC, Potgeiter DJ.
  Title
-cyclopiazonate oxidocyclase from Penicillium cyclopium. II. Studies on electron acceptors, inhibitors, enzyme kinetics, amino acid composition, flavin prosthetic group and other properties.
  Journal
Biochim Biophys Acta 250:329-45 (1971)
Other DBs
ExplorEnz - The Enzyme Database: 1.21.99.1
IUBMB Enzyme Nomenclature: 1.21.99.1
ExPASy - ENZYME nomenclature database: 1.21.99.1
BRENDA, the Enzyme Database: 1.21.99.1
CAS: 9059-00-1

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