KEGG   ENZYME: 1.21.99.4Help
Entry
EC 1.21.99.4                Enzyme                                 

Name
thyroxine 5'-deiodinase;
diiodothyronine 5'-deiodinase [ambiguous];
iodothyronine 5'-deiodinase;
iodothyronine outer ring monodeiodinase;
type I iodothyronine deiodinase;
type II iodothyronine deiodinase;
thyroxine 5-deiodinase [misleading];
L-thyroxine iodohydrolase (reducing)
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With unknown physiological acceptors
BRITE hierarchy
Sysname
3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
Reaction(IUBMB)
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor [RN:R03734]
Reaction(KEGG)
Substrate
3,3',5-triiodo-L-thyronine [CPD:C02465];
iodide [CPD:C00708];
acceptor [CPD:C00028];
H+ [CPD:C00080]
Product
L-thyroxine [CPD:C01829];
reduced acceptor [CPD:C00030]
Comment
The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide.
History
EC 1.21.99.4 created 1984 as EC 3.8.1.4, transferred 2003 to EC 1.97.1.10, transferred 2015 to EC 1.21.99.4
Orthology
K01562  type I thyroxine 5'-deiodinase
K17904  type II thyroxine 5'-deiodinase
Genes
HSA: 1733(DIO1) 1734(DIO2)
PTR: 467521(DIO2) 469331(DIO1)
PPS: 100972089(DIO2) 100980739(DIO1)
GGO: 101124806(DIO2) 101154004(DIO1)
PON: 100440998(DIO1) 100449335(DIO2)
NLE: 100586423(DIO1) 100606409(DIO2)
MCC: 707484(DIO2) 714739(DIO1)
MCF: 102122576(DIO2) 102128623(DIO1)
CSAB: 103224787(DIO1) 103229434(DIO2)
RRO: 104669397(DIO1) 104677628(DIO2)
RBB: 108530802(DIO2) 108531213(DIO1)
CJC: 100385960(DIO1) 100406379(DIO2)
SBQ: 101030674(DIO1) 101037342(DIO2)
MMU: 13370(Dio1) 13371(Dio2)
RNO: 25430(Dio1) 65162(Dio2)
CGE: 100765192(Dio1) 100774757(Dio2)
NGI: 103732556(Dio2) 103734117(Dio1)
HGL: 101697296(Dio2) 101704592(Dio1)
CCAN: 109674806(Dio2) 109684245(Dio1)
OCU: 100101570(DIO1) 100354221(DIO2)
TUP: 102480600(DIO2) 102482647(DIO1)
CFA: 403635(DIO1) 490813(DIO2)
AML: 100466148(DIO1) 100478833(DIO2)
UMR: 103670636(DIO2) 103670695(DIO1)
ORO: 101370186(DIO2) 101370991(DIO1)
FCA: 101088170(DIO2) 493798(DIO1)
PTG: 102948967(DIO1) 102963335(DIO2)
AJU: 106975081(DIO1) 106983577(DIO2)
BTA: 494548(DIO2) 782446(DIO1)
BOM: 102274791(DIO1) 102284841(DIO2)
BIU: 109556270(DIO1) 109565391(DIO2)
PHD: 102323416(DIO1) 102344461(DIO2)
CHX: 102178591(DIO1) 102179571(DIO2)
OAS: 100310792(DIO1) 100310793(DIO2)
SSC: 414379(DIO2) 414380(DIO1)
CFR: 102507259(DIO2) 102518353(DIO1)
CDK: 105086052(DIO2) 105092845(DIO1)
BACU: 103005103(DIO1) 103007605(DIO2)
LVE: 103074814 103080109(DIO1)
OOR: 101275852(DIO1) 101276046(DIO2)
ECB: 100050359(DIO1) 100052547(DIO2)
EPZ: 103541011(DIO1) 103561958(DIO2)
EAI: 106833199(DIO1) 106834802(DIO2)
MYB: 102248197(DIO2) 102261233(DIO1)
MYD: 102756562(DIO2)
HAI: 109384683(DIO2) 109395429(DIO1)
RSS: 109447091(DIO2) 109453242(DIO1)
PALE: 102879053(DIO2) 102888357(DIO1)
LAV: 100658761(DIO2) 100675470(DIO1)
MDO: 100016991(DIO2) 100617416(DIO1)
SHR: 100917546(DIO2) 100923092(DIO1)
OAA: 100073387(DIO2) 100088984(DIO1)
GGA: 373903(DIO2) 395940(DIO1)
MGP: 100546412(DIO1) 100547728(DIO2)
CJO: 107315160(DIO2) 107317722(DIO1)
APLA: 101798258(DIO1) 101798494(DIO2)
ACYG: 106033047(DIO1) 106044546(DIO2)
TGU: 100224791(DIO2) 100231867
GFR: 102037547(DIO1) 102042772(DIO2)
FAB: 101808928(DIO1) 101813353(DIO2)
PHI: 102107712(DIO1) 102112539(DIO2)
PMAJ: 107206229(DIO2) 107208501(DIO1)
CCAE: 111929932(DIO2) 111933026(DIO1)
CCW: 104685655(DIO2) 104695177(DIO1)
FPG: 101918266(DIO1) 101920459(DIO2)
FCH: 102050452(DIO2) 102054399(DIO1)
CLV: 102088777(DIO1) 102092044(DIO2)
EGZ: 104131488(DIO1) 104133264(DIO2)
AAM: 106483152(DIO2) 106497641(DIO1)
ASN: 102372564(DIO1) 102378920(DIO2)
AMJ: 102566890(DIO1) 102570384(DIO2)
PSS: 102445607(DIO1) 102449273(DIO2)
CMY: 102936687(DIO2) 102946702(DIO1)
CPIC: 101940661(DIO2) 101942692(DIO1)
ACS: 100553484(dio2) 100561694(dio1)
PVT: 110079367(DIO2) 110082244(DIO1)
PBI: 103054347(DIO1) 103061704(DIO2)
GJA: 107123704(DIO2) 107124276(DIO1)
XLA: 108699835 373842(dio2.L) 733447(dio1.L)
XTR: 100036737(dio2) 100497874(dio1)
NPR: 108793077(DIO1) 108802676(DIO2)
DRE: 352937(dio2) 799937(dio1)
SRX: 107751736
IPU: 108270487(dio2)
AMEX: 103026954(dio1) 103034785(dio2)
TRU: 100191067(dio1) 100191068(dio2)
LCO: 104918439(dio1) 104922564(dio2)
NCC: 104953535(dio2) 104955483 104965519(dio1)
MZE: 101482729(dio1) 101487411(dio2)
OLA: 100192348(dio2) 101160798(dio1)
XMA: 102232010(dio2) 102232075(dio1)
PRET: 103458987(dio2) 103463606(dio1)
NFU: 107391683(dio2) 107393250(dio1)
KMR: 108230578(dio1) 108244999(dio2)
CSEM: 103383367(dio2)
LCF: 108877349(dio1) 108897919(dio2)
SDU: 111225744(dio2) 111232163(dio1)
HCQ: 109524400(dio2) 109532358(dio1)
BPEC: 110167782(dio1)
MALB: 109964010(dio1)
SASA: 106603085 106613537(dio1)
ELS: 105006472(dio1) 105015440(dio2)
SFM: 108919387(dio2)
LCM: 102351745(DIO2) 102358780(DIO1)
CMK: 103186780(dio2) 103188836(dio1)
SPU: 100893862
CRG: 105326271
LAK: 106151249
DFA: DFA_09530(dio3)
 » show all
Taxonomy
Reference
1  [PMID:7053997]
  Authors
Chopra IJ, Chua Teco GN.
  Title
Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines.
  Journal
Endocrinology 110:89-97 (1982)
DOI:10.1210/endo-110-1-89
Reference
2  [PMID:6176242]
  Authors
Goswami A, Leonard JL, Rosenberg IN.
  Title
Inhibition by coumadin anticoagulants of enzymatic outer ring monodeiodination of iodothyronines.
  Journal
Biochem Biophys Res Commun 104:1231-8 (1982)
DOI:10.1016/0006-291X(82)91382-1
Reference
3  [PMID:7227308]
  Authors
Smallridge RC, Burman KD, Ward KE, Wartofsky L, Dimond RC, Wright FD, Latham KR.
  Title
3',5'-diiodothyronine to 3'-monoiodothyronine conversion in the fed and fasted rat: enzyme characteristics and evidence for two distinct 5'-deiodinases.
  Journal
Endocrinology 108:2336-45 (1981)
DOI:10.1210/endo-108-6-2336
Reference
4  [PMID:11898402]
  Authors
Kohrle J.
  Title
Iodothyronine deiodinases.
  Journal
Methods Enzymol 347:125-67 (2002)
Other DBs
ExplorEnz - The Enzyme Database: 1.21.99.4
IUBMB Enzyme Nomenclature: 1.21.99.4
ExPASy - ENZYME nomenclature database: 1.21.99.4
BRENDA, the Enzyme Database: 1.21.99.4
CAS: 70712-46-8

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