KEGG   ENZYME: 1.3.1.14Help
Entry
EC 1.3.1.14                 Enzyme                                 

Name
dihydroorotate dehydrogenase (NAD+);
orotate reductase (NADH);
orotate reductase (NADH2);
DHOdehase (ambiguous);
DHOD (ambiguous);
DHODase (ambiguous);
dihydroorotate oxidase, pyrD (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-dihydroorotate:NAD+ oxidoreductase
Reaction(IUBMB)
(S)-dihydroorotate + NAD+ = orotate + NADH + H+ [RN:R01869]
Reaction(KEGG)
Substrate
(S)-dihydroorotate [CPD:C00337];
NAD+ [CPD:C00003]
Product
orotate [CPD:C00295];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Binds FMN, FAD and a [2Fe-2S] cluster. The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit [4]. The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
History
EC 1.3.1.14 created 1972, modified 2011
Pathway
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K17828  dihydroorotate dehydrogenase (NAD+) catalytic subunit
Genes
PLUM: A4R40_19480
PTT: VY86_12640
PPG: PputGB1_1769
TCX: Tcr_1950
TCY: Thicy_0261
TAO: THIAE_01490
CYQ: Q91_0030
CZA: CYCME_0030
CYY: CPC19_01375
NOC: Noc_2822
NHL: Nhal_3461
NWA: Nwat_0266
NTT: TAO_0376
TGR: Tgr7_3279
TKM: TK90_0051
TVR: TVD_12980
TBN: TBH_C0334
RMA: Rmag_0006
VOK: COSY_0006(pyrD)
ENM: EBS_0029(pyrD)
CNC: CNE_1c17730(pyrD2)
BOK: DM82_4899
BOC: BG90_5696
BAM: Bamb_5904
PPNO: DA70_07840
PPNM: LV28_22740
PPUL: RO07_17155
PSPU: NA29_20000
PAPI: SG18_15935
AMIM: MIM_c31670(pyrD2)
GSU: GSU1755(pyrD)
GSK: KN400_1779(pyrD)
GME: Gmet_1841(pyrD)
GUR: Gura_2150
GLO: Glov_2304
GBM: Gbem_2399(pyrD)
GEO: Geob_2780(pyrD)
GEM: GM21_1820
GEB: GM18_1770
PCA: Pcar_1296(pyrD)
PPD: Ppro_2629
DES: DSOUD_1702(pyrD)
DEU: DBW_2288
DVU: DVU3316(pyrD)
DVL: Dvul_0072
DVM: DvMF_2143
DDE: Dde_0056
DDS: Ddes_2200
DMA: DMR_16260(pyrD)
DHY: DESAM_22089(pyrD)
DGG: DGI_2557(pyrD)
DTR: RSDT_0940(pyrD)
DAS: Daes_1212
DPI: BN4_10892(pyrD)
PPRF: DPRO_1238(pyrD)
LIP: LI0712(pyrD)
LIR: LAW_00738(pyrD)
DBA: Dbac_2846
DRT: Dret_0019
DPS: DP3015
DSF: UWK_00234
DOL: Dole_1495
DML: Dmul_20990(pyrD1)
DAL: Dalk_0800
DAT: HRM2_29470(pyrD)
DTO: TOL2_C02930(pyrD)
SAT: SYN_02850
SFU: Sfum_2850
DBR: Deba_2878
MET: M446_3011
PDE: Pden_3483
MGM: Mmc1_3426
BSU: BSU15540(pyrD)
BSR: I33_1741
BSL: A7A1_0471
BSH: BSU6051_15540(pyrD)
BSUT: BSUB_01684(pyrD)
BSUL: BSUA_01684(pyrD)
BSUS: Q433_08915
BSS: BSUW23_08000(pyrD)
BST: GYO_1903
BSO: BSNT_08065(pyrD)
BSQ: B657_15540(pyrD)
BLI: BL02278(pyrD)
BLD: BLi01774(pyrD)
BLH: BaLi_c18070(pyrD)
BAY: RBAM_015370(pyrD)
BAQ: BACAU_1508(pyrD)
BYA: BANAU_1505(pyrD)
BAMP: B938_07975
BAML: BAM5036_1473(pyrD)
BAMA: RBAU_1513(pyrD)
BAMN: BASU_1493(pyrD)
BAMB: BAPNAU_2216(pyrD)
BAMT: AJ82_08795
BAMY: V529_14920(pyrD)
BMP: NG74_01598(pyrD)
BAO: BAMF_1625(pyrD)
BAZ: BAMTA208_09385(pyrD)
BQL: LL3_01712(pyrD)
BXH: BAXH7_01909(pyrD)
BQY: MUS_1703(pyrD)
BAMI: KSO_011675
BAMC: U471_15750
BAMF: U722_08160
BATR: TD68_05030
BHA: BH2534(pyrD)
BAN: BA_4023(pyrD)
BAR: GBAA_4023(pyrD)
BAT: BAS3735
BAH: BAMEG_0608(pyrD)
BAI: BAA_4046(pyrD)
BANT: A16_40290
BANR: A16R_40800
BANS: BAPAT_3858
BANV: DJ46_2723(pyrD)
BCE: BC3884
BCA: BCE_3929(pyrD)
BCZ: BCE33L3643(pyrD)
BCR: BCAH187_A3933(pyrD)
BCB: BCB4264_A3982(pyrD)
BCU: BCAH820_3898(pyrD)
BCG: BCG9842_B1259(pyrD)
BCQ: BCQ_3670(pyrD)
BCX: BCA_3985(pyrD)
BAL: BACI_c38370(pyrD)
BNC: BCN_3715
BCF: bcf_19295
BCER: BCK_15815
BTK: BT9727_3626(pyrD)
BTL: BALH_3514
BTB: BMB171_C3549(pyrD)
BTT: HD73_4168
BTHI: BTK_20515
BTC: CT43_CH3885(pyrD)
BTM: MC28_3107(pyrD)
BTG: BTB_c40120(pyrD)
BTI: BTG_30350
BTW: BF38_5054(pyrD)
BWW: bwei_1070(pyrD)
BMYO: BG05_2140(pyrD)
BMYC: DJ92_975(pyrD)
BCL: ABC2331(pyrDI)
BPU: BPUM_1453
BPUM: BW16_08125
BPUS: UP12_07565
BPF: BpOF4_00525(pyrD)
BMQ: BMQ_4250(pyrD)
BMD: BMD_4238(pyrD)
BMH: BMWSH_0978(pyrD)
BMEG: BG04_1169(pyrD)
BAG: Bcoa_0140
BCOA: BF29_88(pyrD)
BJS: MY9_1700
BMET: BMMGA3_05815(pyrD)
BACW: QR42_07425
BACP: SB24_02020
BACB: OY17_10760
BACO: OXB_1984
BACY: QF06_06795
BACL: BS34A_17210(pyrD)
BALM: BsLM_1652
BEO: BEH_18495
BGY: BGLY_1768(pyrD)
BKW: BkAM31D_15090(pyrD)
BBEV: BBEV_1890(pyrD)
OIH: OB1493(pyrD)
GKA: GK1154(pyrD)
GTN: GTNG_1011(pyrD)
GGH: GHH_c10840(pyrD)
GEA: GARCT_01166(pyrD)
AFL: Aflv_1801(pyrD)
AAMY: GFC30_1448
ANL: GFC29_330
AXL: AXY_15600(pyrD)
HHD: HBHAL_2901(pyrD)
VPN: A21D_03714(pyrD)
BSE: Bsel_1678
SCA: SCA_0819(pyrD)
SDT: SPSE_1597(pyrD)
SHU: SHYC_08405(pyrD)
SSCH: LH95_07800
SSCZ: RN70_08310
SAGQ: EP23_02020
MCL: MCCL_0775(pyrD)
MCAK: MCCS_10040(pyrD)
LMO: lmo1833(pyrD)
LMN: LM5578_2035(pyrD)
LMY: LM5923_1986(pyrD)
LMOC: LMOSLCC5850_1895(pyrD)
LMOE: BN418_2205
LMOB: BN419_2206
LMOD: LMON_1901(pyrD)
LMOW: AX10_03400
LMOQ: LM6179_2603(pyrD)
LMR: LMR479A_1943(pyrD)
LMOM: IJ09_00665
LMF: LMOf2365_1861(pyrD)
LMC: Lm4b_01849(pyrD)
LMOG: BN389_18580(pyrD)
LMP: MUO_09410
LMOL: LMOL312_1842(pyrD)
LMOX: AX24_06930
LMQ: LMM7_1926(pyrD)
LML: lmo4a_1890(pyrD)
LMS: LMLG_2076
LMW: LMOSLCC2755_1894(pyrD)
LMX: LMOSLCC2372_1899(pyrD)
LMZ: LMOSLCC2482_1895(pyrD)
LMON: LMOSLCC2376_1794(pyrD)
LMOS: LMOSLCC7179_1806(pyrD)
LMOO: LMOSLCC2378_1856(pyrD)
LMOY: LMOSLCC2479_1897(pyrD)
LMOT: LMOSLCC2540_1915(pyrD)
LMOA: LMOATCC19117_1850(pyrD)
LMOK: CQ02_09515
LIN: pyrD
LWE: lwe1852(pyrD)
LSG: lse_1813(pyrD)
LIV: LIV_1809(pyrD)
ESI: Exig_1941
EAN: Eab7_1792(pyrD)
GMO: NCTC11323_01176(pyrD)
PPY: PPE_04771
PPM: PPSC2_24785(pyrD3)
PPO: PPM_4925(pyrD3)
PPOL: X809_41330
PPOY: RE92_12500
PLV: ERIC2_c28940(pyrD2)
PSAB: PSAB_13800
PRI: PRIO_3785(pyrD3)
ASOC: CB4_01694(pyrD)
SIV: SSIL_3070(pyrD)
JEO: JMA_16210
LLA: L182555(pydB)
LLK: LLKF_1437(pyrD)
LLT: CVCAS_1313(pyrD)
LLS: lilo_1320(pydB)
LLX: NCDO2118_1399(pyrD)
LLC: LACR_1469
LLM: llmg_1106(pyrDB)
LLR: llh_7380
LLI: uc509_1360(pyrDB)
LLW: kw2_1332
LLJ: LG36_1039(pyrD)
LGR: LCGT_1337
LGV: LCGL_1358
LPK: LACPI_1026(pyrDB)
SPN: SP_0964(pyrDB)
SPD: SPD_0852(pyrDb)
SPR: spr0866(pyrD)
SPW: SPCG_0940(pyrD)
SJJ: SPJ_0905
SNV: SPNINV200_08850(pyrD)
SPX: SPG_0888
SNT: SPT_1239
SND: MYY_1240
SPNN: T308_05800
SNE: SPN23F08890(pyrD)
SPV: SPH_1065
SPP: SPP_0970
SNI: INV104_08250(pyrD)
SNP: SPAP_0996
SNX: SPNOXC08660(pyrD)
SNU: SPNA45_01262(pyrD)
SPNE: SPN034156_19080(pyrD)
SPNU: SPN034183_08640(pyrD)
SPNM: SPN994038_08530(pyrD)
SPNO: SPN994039_08540(pyrD)
SMU: SMU_1223(pyrDB)
SMC: SmuNN2025_0830(pyrDB)
SMJ: SMULJ23_0830(pyrDB)
SMUA: SMUFR_1071
STC: str0955(pyrDb)
STL: stu0955(pyrDb)
STE: STER_0969
STN: STND_0918
STU: STH8232_1158(pyrD1)
STW: Y1U_C0931
STHE: T303_05845
SSA: SSA_1242(pyrD)
SSB: SSUBM407_0911(pyrD)
SSI: SSU0867(pyrD)
SSS: SSUSC84_0913(pyrD)
SUP: YYK_04105
SSUY: YB51_5155
SSUT: TL13_0914(pyrD)
SSUI: T15_1006
SGO: SGO_1255(pyrd)
SGA: GALLO_0967(pyrD)
SGG: SGGBAA2069_c09410(pyrD1)
SGT: SGGB_0956(pyrD2)
SMB: smi_0965(pyrD1)
SOR: SOR_1205(pyrDI)
STB: SGPB_0833(pyrD.2)
SCF: Spaf_0952(pyrD)
SSR: SALIVB_1010(pyrDB)
STF: Ssal_01079(pyrD)
STJ: SALIVA_1122(pyrDB)
SSAH: HSISS4_00974(pyrDb)
SMN: SMA_0879(pyrDB)
SIF: Sinf_0734(pyrD)
SIE: SCIM_0937(pyrD)
SIB: SIR_0695(pyrD)
SIU: SII_0707(pyrD)
SANG: SAIN_0800(pyrD)
SANC: SANR_0905(pyrD)
SANS: DK43_06080
SCG: SCI_0781(pyrD)
SCON: SCRE_0760(pyrD)
SCOS: SCR2_0760(pyrD)
SLU: KE3_0797
STRN: SNAG_1217(pyrDB)
LPL: lp_2699(pyrD)
LPJ: JDM1_2164(pyrD)
LPT: zj316_2595(pyrD)
LPS: LPST_C2219(pyrD)
LPZ: Lp16_2124
LSA: LCA_0957(pyrDB)
LCA: LSEI_1451
LPAP: LBPC_1374
LCB: LCABL_16740(pyrD)
LCS: LCBD_1655
LCE: LC2W_1622
LCW: BN194_16440(pyrD)
LRE: Lreu_0125
LRF: LAR_0119
LRT: LRI_1833
LRH: LGG_01455(purD)
LRG: LRHM_1398
LRL: LC705_01472(purD)
LRA: LRHK_1456(pyrDB)
LHO: LOOC260_122150(pyrD)
PPE: PEPE_0317
PPEN: T256_01675
PCE: PECL_483(pyrD)
EFA: EF1714(pyrD-2)
EFL: EF62_2090
EFI: OG1RF_11425(pyrDB)
EFS: EFS1_1469(pyrD-2)
EFN: DENG_01893(pyrD)
EFQ: DR75_713(pyrDB)
ENE: ENT_11210
EFC: EFAU004_00964(pyrDB)
EFAU: EFAU085_01382(pyrDB)
EFU: HMPREF0351_11355(pyrD)
EFM: M7W_1863
EHR: EHR_12105
ECAS: ECBG_00988
EMU: EMQU_1343
EDU: LIU_07820
MPS: MPTP_1155
MPX: MPD5_0797
LCI: LCK_00998(pyrDB)
LKI: LKI_01245
LGS: LEGAS_0872(pyrDB)
CRN: CAR_c12160(pyrD)
CML: BN424_1712(pyrDB)
CARC: NY10_614
CAC: CA_C2650(pyrD)
CAE: SMB_G2685(pyrD)
CAY: CEA_G2659(pyrD)
CPE: CPE1178
CPF: CPF_1382(pyrD)
CPR: CPR_1197(pyrD)
CBO: CBO3236(pyrD)
CBA: CLB_3273(pyrD)
CBH: CLC_3147(pyrD)
CBY: CLM_3648(pyrD)
CBL: CLK_2634(pyrD)
CBK: CLL_A2576
CBB: CLD_1295(pyrD)
CBI: CLJ_B3509(pyrD)
CBN: CbC4_2146
CBT: CLH_2342(pyrD)
CBF: CLI_3375(pyrD)
CBM: CBF_3368(pyrD)
CBE: Cbei_1005
CBZ: Cbs_1005
CBEI: LF65_01057
CKL: CKL_3356(pyrD2)
CKR: CKR_2964
CLJ: CLJU_c35690(pyrD)
CLS: CXIVA_05180(PyrD) CXIVA_14370(PyrD)
CSR: Cspa_c10910(pyrD)
CPAS: Clopa_1628
CPAT: CLPA_c26860(pyrD2)
CPAE: CPAST_c26860(pyrD2)
CSB: CLSA_c12500(pyrD)
CLT: CM240_2166(pyrD)
CBV: U729_2030
CSQ: CSCA_4636
CLD: CLSPO_c33390(pyrD)
CACE: CACET_c33470(pyrD)
CTYK: CTK_C25730(pyrD)
AMT: Amet_4208
AOE: Clos_2191
CLO: HMPREF0868_0716(pyrD)
CTH: Cthe_0947
HSC: HVS_09045(pyrD)
CCE: Ccel_0618
CSS: Cst_c06420(pyrD)
CSD: Clst_0610
ESR: ES1_01830
ESU: EUS_19900
CCEL: CCDG5_1009(pyrD)
RBR: RBR_00230
RCH: RUM_18750
RUM: CK1_20020
RUS: RBI_I00678(pyrD)
FPR: FP2_15410
FPA: FPR_16800
BPB: bpr_I2788(pyrD)
BFI: CIY_00470
BHU: bhn_I2610
RIX: RO1_21820
RIM: ROI_09130
COO: CCU_24020
CCT: CC1_28970
ROB: CK5_10090
RTO: RTO_05900
CPY: Cphy_2286
CSO: CLS_19390
BPRL: CL2_17590
HSD: SD1D_1753(pyrD)
CPRO: CPRO_23590(pyrD)
ERT: EUR_26530
ERA: ERE_07570
CDF: CD630_01860(pyrD)
PDC: CDIF630_00307(pyrD)
CDC: CD196_0199(pyrD)
CDL: CDR20291_0187(pyrD)
PDF: CD630DERM_01860(pyrD)
EAC: EAL2_c09490(pyrD)
CST: CLOST_0277(pyrD)
STH: STH1260
SWO: Swol_1279
SLP: Slip_0841
DSY: DSY2857
DHD: Dhaf_4014
DRM: Dred_1686
DAE: Dtox_2350
PTH: PTH_1806(PyrD)
DAU: Daud_1300
SGY: Sgly_0680
HMO: HM1_2112(pyrD)
ELM: ELI_4154
EHL: EHLA_2115
AWO: Awo_c16200(pyrD)
OVA: OBV_06650(pyrD)
TMR: Tmar_2047
SAY: TPY_3443(pyrD)
CTHM: CFE_1090
BPRM: CL3_34830
BPRS: CK3_16090
TTE: TTE1530(PyrD)
THX: Thet_1123
TIT: Thit_1335
TKI: TKV_c14390(pyrD)
CHY: CHY_1497(pyrD)
TAE: TepiRe1_2651(pyrD)
MTA: Moth_2127
ADG: Adeg_0375
TPZ: Tph_c14430(pyrD1)
CSC: Csac_1936
ATE: Athe_1380
TTM: Tthe_1540
TSH: Tsac_1706
TACI: TDSAC_1130
FMA: FMG_0725
APR: Apre_0785
PMIC: NW74_07520
PED: ING2D1G_0555(pyrD)
CAD: Curi_c07070(pyrD)
VPR: Vpar_0568
VRM: 44547418_00589(pyrDB)
MED: MELS_1860
SRI: SELR_16830(pyrD)
PUF: UFO1_1606
PFT: JBW_02743
AIN: Acin_1026(pyrD)
EUC: EC1_21160
LPIL: LIP_0116
MPE: MYPE7860(MYPE7860)
ELJ: ELUMI_v1c00160(pyrDI)
EFR: EFREU_v1c01010(pyrDI)
SCR: SCHRY_v1c02480(pyrD)
SERI: SERIO_v1c04270(pyrDI)
SLL: SLITO_v1c07830(pyrDI)
SCOU: SCORR_v1c07420(pyrDI)
MBJ: KQ51_01648(pyrD_2)
SALU: DC74_7570
SALL: SAZ_39065
STRE: GZL_09035
SAMB: SAM23877_6661(cgc5)
SRW: TUE45_00678(pyrDB)
AAI: AARI_31480(pyrDI)
SERJ: SGUI_0195
DCO: SAMEA4475696_1263(pyrD)
PAC: PPA1002
PAW: PAZ_c10440(pyrD2)
PACC: PAC1_05265
PACH: PAGK_1151
CACN: RN83_05370
CGRN: 4412665_01193(pyrDB)
PBO: PACID_15110(pyrD)
ACIJ: JS278_01822(pyrDB)
NDK: I601_3019(pyrD_2)
TFU: Tfu_1059
NDA: Ndas_3100
NAL: B005_0059
TCU: Tcur_3010
SRO: Sros_2810
ACE: Acel_1296
MMAR: MODMU_3319(pyrD)
SEN: SACE_2136(pyrD)
KAL: KALB_5554
ACTI: UA75_24500
ACAD: UA74_23995
AHG: AHOG_21895(pyrD1)
AHE: Arch_1022
BLO: BL0789(pyrD)
BLJ: BLD_0529(pyrD1)
BLN: Blon_1446
BLON: BLIJ_1492
BLF: BLIF_0944
BLL: BLJ_0955
BLB: BBMN68_529(pyrD1)
BLM: BLLJ_0824
BLG: BIL_10130
BAD: BAD_0764(pyrD)
BADL: BADO_0812
BLA: BLA_1391(pyrD)
BBB: BIF_00173
BBC: BLC1_0835
BLV: BalV_0841
BLW: W7Y_0877
BLS: W91_0898
BANI: Bl12_0817
BANL: BLAC_04450
BANM: EN10_04440
BDE: BDP_1095(pyrD)
BDN: BBDE_1049
BBI: BBIF_0898(pyrD1)
BBP: BBPR_0942(pyrD)
BBF: BBB_0878(pyrD)
BBRU: Bbr_0978(pyrD1)
BBRE: B12L_0897
BBRV: B689b_0990
BBRJ: B7017_1013
BBRC: B7019_1052
BBRN: B2258_0942
BBRS: BS27_0977(pyrD1)
BBRD: BBBR_0926
BAST: BAST_0829
BTP: D805_1089
BCOR: BCOR_0712
BKS: BBKW_0894
BPSP: AH67_04735
BANG: BBAG_0720
BCAT: BBCT_0867
BPSC: BBPC_0866
BSCA: BBSC_1273
GVG: HMPREF0421_20752(pyrD)
SIJ: SCIP_0651
PDO: PSDT_0831
TBI: Tbis_1357
RXY: Rxyl_1475
CWO: Cwoe_3206
AFO: Afer_1698
AYM: YM304_20470(pyrD)
ELE: Elen_1663
EYY: EGYY_14550(PyrD)
AEQ: AEQU_1098
APV: Apar_0811
OLS: Olsu_0989
CBAC: JI75_03905
DET: DET1372(pyrD)
DEH: cbdbA1324(pyrD)
DEV: DhcVS_1153(pyrD)
DMC: btf_1250
DMD: dcmb_1231
DMG: GY50_1211
DUC: UCH007_11340(pyrD)
DFO: Dform_00160(pyrDI)
RCA: Rcas_4448
CAU: Caur_2338
CAG: Cagg_3055
ATM: ANT_09400
ABAT: CFX1CAM_1149(pyrD)
RBA: RB8748(pyrD)
PSL: Psta_3116
PIR: VN12_11175(pyrD)
PLM: Plim_0772
PLS: VT03_07260(pyrDB)
PLH: VT85_03390(pyrD)
FMR: Fuma_02382(pyrD_1)
TTF: THTE_2024
GES: VT84_34640(pyrD)
IPA: Isop_3090
SACI: Sinac_0739
PBOR: BSF38_02776(pyrD)
KST: KSMBR1_0406(pyrD)
PBU: L21SP3_02106(pyrD)
PBAS: SMSP2_02371(pyrD)
PBP: STSP1_01004(pyrD)
VBL: L21SP4_02054(pyrD_2)
TDE: TDE0982
TPED: TPE_0888
BRM: Bmur_2402
BPJ: B2904_orf275(pyrD)
BPW: WESB_2415(pyrD)
BIP: Bint_0832
ACA: ACP_2970(pyrD)
ABAS: ACPOL_1488
SUS: Acid_4402
ABAC: LuPra_00656(pyrDB)
EMI: Emin_0729
EPO: Epro_0633(pyrD)
ETI: RSTT_703(pyrD)
RSD: TGRD_743
FNU: FN0424
FVA: FV113G1_11030(pyrD)
TAI: Taci_1089
TLI: Tlie_1093
SBR: SY1_07910
GAU: GAU_1979(pyrD)
GBA: J421_3582
BTH: BT_0892
BTHO: Btheta7330_02524(pyrD_1)
BFR: BF2400
BFS: BF9343_2402(pyrD1)
BFG: BF638R_2442(pyrD1)
BVU: BVU_3309
BXY: BXY_04760
BOA: Bovatus_00754(pyrD)
BCEL: BcellWH2_05364(pyrD)
PGI: PG_1065(pyrD)
PGN: PGN_0905
PGT: PGTDC60_1143(pyrD)
PCRE: NCTC12858_01373(pyrD_2)
PBT: ING2E5B_1033(pyrD)
PMUC: ING2E5A_1707(pyrD3)
PDI: BDI_1112
TFO: BFO_0020
PSAC: PSM36_1863(pyrD)
APS: CFPG_578
PRU: PRU_0543(pyrD)
AFD: Alfi_2311
ASH: AL1_30870
DORI: FH5T_18925
MBAS: ALGA_3992
HSW: Hsw_3823
CTE: CT1597(pyrDI)
CPC: Cpar_1526
CCH: Cag_1783
CLI: Clim_1863
PVI: Cvib_1387
PLT: Plut_1596
PPH: Ppha_0721
PAA: Paes_0553
PROC: Ptc2401_00574(pyrD_1)
CTS: Ctha_0734
IAL: IALB_1617(pyrD)
MRO: MROS_0014
CACI: CLOAM1308(pyrD)
AAE: aq_046(pyrD)
HTH: HTH_0418(pyrD)
TAL: Thal_0099
TMA: TM0333
TMW: THMA_0341
TMQ: THMB_0341
TMX: THMC_0341
TPT: Tpet_0586
TRQ: TRQ2_0600
TNA: CTN_0335
TNP: Tnap_0969
TLE: Tlet_1923
TME: Tmel_0267
TAF: THA_510(pyrD)
THER: Y592_02465
FNO: Fnod_0461
PMO: Pmob_0657
MARN: LN42_02185
DTN: DTL3_0060
MINF: MESINF_2827(pyrD)
DDF: DEFDS_1219(pyrD)
CABY: Cabys_3161(pyrD)
DTU: Dtur_1572
CTHI: THC_1001
MOX: DAMO_2146(pyrD)
MJA: MJ_0654
MMP: MMP0439(pyrD)
MMD: GYY_02270
MAE: Maeo_0912
MVO: Mvol_1191
MTH: MTH_1213
MMG: MTBMA_c15980(pyrD)
METC: MTCT_1105
MWO: MWSIV6_1605(pyrD)
METE: tca_01170(pyrD_2)
MST: Msp_1421(pyrD)
MSI: Msm_1044
MRU: mru_1986(pyrD)
MEB: Abm4_1559(pyrD)
MMIL: sm9_2057(pyrD)
MEYE: TL18_09465
MOL: YLM1_1425
METH: MBMB1_1748(pyrD)
MFC: BRM9_0320(pyrD)
MFI: DSM1535_0984(pyrD)
MCUB: MCBB_2062(pyrD)
MFV: Mfer_1154
MKA: MK0563(pyrD)
AFU: AF_0745
FPL: Ferp_0054
GAC: GACE_0760
GAH: GAH_01832
TAC: Ta0404
TVO: TVG1224769(TVG1224769)
PTO: PTO0175
FAI: FAD_1256
CDIV: CPM_0762
MEAR: Mpt1_c05890(pyrD)
MARC: AR505_1029
ABI: Aboo_0832
PHO: PH1516(PH1516)
PAB: PAB1936
PFU: PF1539
PFI: PFC_06925
PYN: PNA2_0102
PYS: Py04_1409
TKO: TK2260
TON: TON_1264
TGA: TGAM_0356(pyrD)
TSI: TSIB_0441
THE: GQS_08785
THA: TAM4_1200
THM: CL1_1365
TLT: OCC_09998
TNU: BD01_1552
TEU: TEU_04195
PPAC: PAP_04340
MAC: MA_0583(pyrD)
MBAR: MSBR2_1955
MBAK: MSBR3_2000
MMA: MM_1745
MMAC: MSMAC_1500
METM: MSMTP_2882
MTHE: MSTHC_1189
MTHR: MSTHT_2095
MHOR: MSHOH_3646
MBU: Mbur_1225(pyrD)
MMET: MCMEM_1677
MMH: Mmah_1462
MPY: Mpsy_2486
MTP: Mthe_0450
MCJ: MCON_2335(pyrD)
MHI: Mhar_1443
MHU: Mhun_1154
MLA: Mlab_0593
MBG: BN140_0850(pyrD)
MEMA: MMAB1_1115(pyrD)
MPI: Mpet_1927
MBN: Mboo_1110
MPL: Mpal_1742
MPD: MCP_1553(pyrD)
MEZ: Mtc_1012(pyrD)
RCI: LRC390(pyrD)
APE: APE_0260.1(pyrD)
ACJ: ACAM_0199(pyrD)
SMR: Smar_0597
IHO: Igni_0227
IIS: EYM_00095
DKA: DKAM_0474
IAG: Igag_1404
HBU: Hbut_0261
TPE: Tpen_1161
ASC: ASAC_0967
ACIA: SE86_04515
NMR: Nmar_1390
NID: NPIRD3C_2051(pyrD)
NIN: NADRNF5_0490(pyrD)
NCT: NMSP_0355
TAA: NMY3_02510(pyrD)
NCV: NCAV_0729(pyrD)
NBV: T478_1081
NDV: NDEV_1676(pyrD)
KCR: Kcr_0240
BARC: AOA65_0471
BARB: AOA66_1659
LOKI: Lokiarch_03490(pyrD_1) Lokiarch_48320(pyrD_2)
 » show all
Taxonomy
Reference
1  [PMID:13610849]
  Authors
FRIEDMANN HC, VENNESLAND B.
  Title
Purification and properties of dihydro-orotic dehydrogenase.
  Journal
J Biol Chem 233:1398-406 (1958)
Reference
2  [PMID:13825167]
  Authors
FRIEDMANN HC, VENNESLAND B.
  Title
Crystalline dihydroorotic dehydrogenase.
  Journal
J Biol Chem 235:1526-32 (1960)
Reference
3  [PMID:13115431]
  Authors
LIEBERMAN I, KORNBERG A.
  Title
Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase.
  Journal
Biochim Biophys Acta 12:223-34 (1953)
DOI:10.1016/0006-3002(53)90141-3
Reference
4  [PMID:8910599]
  Authors
Nielsen FS, Andersen PS, Jensen KF
  Title
The B form of dihydroorotate dehydrogenase from Lactococcus lactis consists of two different subunits, encoded by the pyrDb and pyrK genes, and contains FMN, FAD, and [FeS] redox centers.
  Journal
J Biol Chem 271:29359-65 (1996)
DOI:10.1074/jbc.271.46.29359
  Sequence
Reference
5  [PMID:11188687]
  Authors
Rowland P, Norager S, Jensen KF, Larsen S
  Title
Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
  Journal
Structure 8:1227-38 (2000)
DOI:10.1016/S0969-2126(00)00530-X
  Sequence
Reference
6  [PMID:10545205]
  Authors
Kahler AE, Nielsen FS, Switzer RL
  Title
Biochemical characterization of the heteromeric Bacillus subtilis dihydroorotate  dehydrogenase and its isolated subunits.
  Journal
Arch Biochem Biophys 371:191-201 (1999)
DOI:10.1006/abbi.1999.1455
  Sequence
Reference
7  [PMID:10529184]
  Authors
Marcinkeviciene J, Tinney LM, Wang KH, Rogers MJ, Copeland RA
  Title
Dihydroorotate dehydrogenase B of Enterococcus faecalis. Characterization and insights into chemical mechanism.
  Journal
Biochemistry 38:13129-37 (1999)
DOI:10.1021/bi990674q
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.14
IUBMB Enzyme Nomenclature: 1.3.1.14
ExPASy - ENZYME nomenclature database: 1.3.1.14
BRENDA, the Enzyme Database: 1.3.1.14
CAS: 37255-26-8

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