KEGG   ENZYME: 1.3.1.21Help
Entry
EC 1.3.1.21                 Enzyme                                 

Name
7-dehydrocholesterol reductase;
DHCR7 (gene name);
7-DHC reductase;
7-dehydrocholesterol dehydrogenase/cholesterol oxidase;
Delta7-sterol reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cholesterol:NADP+ Delta7-oxidoreductase
Reaction(IUBMB)
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ [RN:R01456]
Reaction(KEGG)
Substrate
cholesterol [CPD:C00187];
NADP+ [CPD:C00006]
Product
cholesta-5,7-dien-3beta-ol [CPD:C01164];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is part of the cholesterol biosynthesis pathway.
History
EC 1.3.1.21 created 1972, modified 2013
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00213  7-dehydrocholesterol reductase
Genes
HSA: 1717(DHCR7)
PTR: 451393(DHCR7)
PPS: 100977099(DHCR7)
GGO: 101137517(DHCR7)
PON: 100172090(DHCR7)
NLE: 100580795(DHCR7)
MCC: 106993167(DHCR7)
MCF: 102120769(DHCR7)
CSAB: 103243806(DHCR7)
RRO: 104677122(DHCR7)
RBB: 108538891(DHCR7)
CJC: 100414321(DHCR7)
SBQ: 101045756(DHCR7)
MMU: 13360(Dhcr7)
RNO: 64191(Dhcr7)
CGE: 100771700(Dhcr7)
HGL: 101703035(Dhcr7)
CCAN: 109689788(Dhcr7)
TUP: 102493586(DHCR7)
CFA: 483675(DHCR7)
AML: 100467495(DHCR7)
UMR: 103671131(DHCR7)
ORO: 101368291(DHCR7)
FCA: 101089143(DHCR7)
PTG: 102956988(DHCR7)
AJU: 106982857(DHCR7)
BTA: 514745(DHCR7)
BOM: 102276304(DHCR7)
BIU: 109554435(DHCR7)
PHD: 102315903(DHCR7)
CHX: 102171848(DHCR7)
OAS: 101118320(DHCR7)
SSC: 100627707(DHCR7)
CFR: 102517817(DHCR7)
CDK: 105104565(DHCR7)
BACU: 103016099(DHCR7)
LVE: 103089128(DHCR7)
OOR: 101275459(DHCR7)
ECB: 100061433(DHCR7)
EPZ: 103564418(DHCR7)
EAI: 106822732(DHCR7)
MYD: 102760533(DHCR7)
HAI: 109389313(DHCR7)
RSS: 109460362(DHCR7)
PALE: 102892007(DHCR7)
LAV: 100670197(DHCR7)
TMU: 101359219
MDO: 100017714(DHCR7)
SHR: 111721517(DHCR7)
OAA: 100074666(DHCR7)
GGA: 422982(DHCR7)
MGP: 100550588
CJO: 107314280(DHCR7)
APLA: 101800178(DHCR7)
ACYG: 106044822(DHCR7)
TGU: 100230558(DHCR7)
GFR: 102043315(DHCR7)
FAB: 101808729(DHCR7)
PHI: 102100206(DHCR7)
PMAJ: 107206252(DHCR7)
CCAE: 111930662(DHCR7)
CCW: 104697600(DHCR7)
FPG: 101914766(DHCR7)
FCH: 102053203(DHCR7)
CLV: 102086618(DHCR7)
EGZ: 104124694(DHCR7)
AAM: 106498340(DHCR7)
ASN: 102380697(DHCR7)
AMJ: 106737545(DHCR7)
PSS: 102459270(DHCR7)
CMY: 102947477(DHCR7)
CPIC: 101947621(DHCR7)
ACS: 100565806(dhcr7)
PVT: 110073543(DHCR7)
PBI: 103061207(DHCR7)
GJA: 107121513(DHCR7)
XLA: 379273(dhcr7) 380248(dhcr7.L)
XTR: 394844(dhcr7)
NPR: 108785887(DHCR7)
DRE: 378446(dhcr7)
SRX: 107727115(dhcr7) 107730061
IPU: 108271323(dhcr7)
AMEX: 103033332(dhcr7)
TRU: 101071896(dhcr7)
LCO: 104935369(dhcr7)
MZE: 101465690(dhcr7)
OLA: 101175471(dhcr7)
XMA: 102220981(dhcr7)
PRET: 103462241(dhcr7)
NFU: 107395662(dhcr7)
KMR: 108237854(dhcr7)
CSEM: 103378635(dhcr7)
LCF: 108897736(dhcr7)
SDU: 111222421(dhcr7)
HCQ: 109524562(dhcr7)
BPEC: 110162584(dhcr7)
MALB: 109963393(dhcr7)
SASA: 106562054(dhcr7) 106587139
OTW: 112249041 112263572(dhcr7)
ELS: 105017269(dhcr7)
SFM: 108941239(dhcr7)
LCM: 102362669(DHCR7)
CMK: 103175009(dhcr7)
CIN: 100176643
SPU: 576295
APLC: 110978603
SKO: 100376362
CLEC: 106662750
ZNE: 110832336
TUT: 107368480
CRG: 105325856
OBI: 106876505
LAK: 106169024
EPA: 110242772
AQU: 100636367
ATH: AT1G50430(DWF5)
CRB: 17900471
BOE: 106328352
THJ: 104809047
CPAP: 110808001
CIT: 102631279
TCC: 18595600
GRA: 105777576
EGR: 104450695
GMX: 102659420
VRA: 106772893
CCAJ: 109807985
CAM: 101512763
LJA: Lj3g3v2039890.1(Lj3g3v2039890.1)
ADU: 107482511
AIP: 107638378
LANG: 109357091
FVE: 101313328
PPER: 18783828
PMUM: 103327428
PAVI: 110749995
CSV: 101215997
CMO: 103500620
MCHA: 111016744
CMAX: 111494288
CMOS: 111464317
CPEP: 111778421
RCU: 8259961
JCU: 105646146
JRE: 109004249
VVI: 100256426
SOT: 102589505 102604909(StDWF5)
NSY: 104249643
NTO: 104116435
INI: 109190803
SIND: 105157928
LSV: 111910394
CCAV: 112516735
DCR: 108205433
BVG: 104907279
SOE: 110785582
NNU: 104611738
OSA: 4329318
DOSA: Os02t0465400-01(Os02g0465400)
OBR: 102721516
BDI: 100831660
ATS: 109780148(LOC109780148)
SBI: 8084478
ZMA: 100282098(pco110886)
SITA: 101767487
MUS: 103989528
DCT: 110113328
AOF: 109840367
ATR: 18440694
SMO: SELMODRAFT_135440(DWF5-2) SELMODRAFT_185064(DWF5-1)
APRO: F751_0259
MGR: MGG_03765
CMT: CCM_08633
PTE: PTT_18374
SPAR: SPRG_01085
CBU: CBU_1158
CBD: CBUD_1256
CBC: CbuK_1025
LLO: LLO_1320(DWF)
LFA: LFA_1070(DWF)
LHA: LHA_0011(DWF)
LLG: 44548918_01594(DWF)
TMC: LMI_2237(DWF)
PCU: pc1220(dhcR7)
PNL: PNK_0661(dhcr7)
PUV: PUV_11120(DWF5)
WCH: wcw_1842(dhcr7)
 » show all
Taxonomy
Reference
1  [PMID:14189869]
  Authors
DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW.
  Title
THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN CHOLESTEROL BIOSYNTHESIS.
  Journal
J Biol Chem 239:1381-7 (1964)
Reference
2  [PMID:9465114]
  Authors
Moebius FF, Fitzky BU, Lee JN, Paik YK, Glossmann H
  Title
Molecular cloning and expression of the human delta7-sterol reductase.
  Journal
Proc Natl Acad Sci U S A 95:1899-902 (1998)
DOI:10.1073/pnas.95.4.1899
  Sequence
[hsa:1717]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.21
IUBMB Enzyme Nomenclature: 1.3.1.21
ExPASy - ENZYME nomenclature database: 1.3.1.21
BRENDA, the Enzyme Database: 1.3.1.21
CAS: 9080-21-1

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