KEGG   ENZYME: 1.3.1.22Help
Entry
EC 1.3.1.22                 Enzyme                                 

Name
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+);
cholestenone 5alpha-reductase;
testosterone Delta4-5alpha-reductase;
steroid 5alpha-reductase;
3-oxosteroid Delta4-dehydrogenase;
5alpha-reductase;
steroid 5alpha-hydrogenase;
3-oxosteroid 5alpha-reductase;
testosterone Delta4-hydrogenase;
4-ene-3-oxosteroid 5alpha-reductase;
reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase;
4-ene-5alpha-reductase;
Delta4-3-ketosteroid 5alpha-oxidoreductase;
cholest-4-en-3-one 5alpha-reductase;
testosterone 5alpha-reductase;
3-oxo-5alpha-steroid 4-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-oxo-5alpha-steroid:NADP+ Delta4-oxidoreductase
Reaction(IUBMB)
a 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-Delta4-steroid + NADPH + H+ [RN:R02610]
Reaction(KEGG)
Substrate
3-oxo-5alpha-steroid [CPD:C02940];
NADP+ [CPD:C00006]
Product
3-oxo-Delta4-steroid [CPD:C00619];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme catalyses the conversion of assorted 3-oxo-Delta4 steroids into their corresponding 5alpha form. Substrates for the mammalian enzyme include testosterone, progesterone, and corticosterone. Substrates for the plant enzyme are brassinosteroids such as campest-4-en-3-one and (22alpha)-hydroxy-campest-4-en-3-one. cf. EC 1.3.99.5, 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor).
History
EC 1.3.1.22 created 1972, modified 2012
Pathway
ec00140  Steroid hormone biosynthesis
ec00905  Brassinosteroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09591  steroid 5-alpha-reductase
K12343  3-oxo-5-alpha-steroid 4-dehydrogenase 1
K12344  3-oxo-5-alpha-steroid 4-dehydrogenase 2
K12345  3-oxo-5-alpha-steroid 4-dehydrogenase 3
Genes
HSA: 6715(SRD5A1) 6716(SRD5A2) 79644(SRD5A3)
PTR: 100614992(SRD5A2) 471241(SRD5A3) 743740(SRD5A1)
PPS: 100978730(SRD5A1) 100986960(SRD5A2) 100987485(SRD5A3)
GGO: 101127484(SRD5A3) 101128506 101138758(SRD5A2) 101143956(SRD5A1)
PON: 100444341(SRD5A1) 100454013(SRD5A2) 100461714(SRD5A3)
NLE: 100597634(SRD5A2) 100604898(SRD5A3) 100607932(SRD5A1)
MCC: 695103(SRD5A1) 696381(SRD5A3) 705676(SRD5A2)
MCF: 102115639(SRD5A2) 102126671(SRD5A1) 102135568(SRD5A3)
CSAB: 103214971(SRD5A1) 103220536(SRD5A2) 103235668(SRD5A3)
RRO: 104662017(SRD5A3) 104669588(SRD5A2) 104672270(SRD5A1) 104674089
RBB: 108516633(SRD5A2) 108522884(SRD5A1) 108531594(SRD5A3)
CJC: 100386366(SRD5A1) 100409457(SRD5A3) 100415292(SRD5A2)
SBQ: 101035698(SRD5A3) 101043426(SRD5A2) 101044295(SRD5A1)
MMU: 57357(Srd5a3) 78925(Srd5a1) 94224(Srd5a2)
RNO: 24950(Srd5a1) 305291(Srd5a3) 64677(Srd5a2)
CGE: 100761447(Srd5a1) 100766917(Srd5a2) 100770660(Srd5a3)
NGI: 103734389(Srd5a3) 103735348(Srd5a1) 103748375(Srd5a2)
HGL: 101708836(Srd5a2) 101714960(Srd5a1) 101726767(Srd5a3)
CCAN: 109693823(Srd5a1) 109698967(Srd5a3) 109702049(Srd5a2)
OCU: 100343882(SRD5A2) 100346041(SRD5A3) 100349876(SRD5A1)
TUP: 102478179(SRD5A2) 102493739(SRD5A3) 102500370(SRD5A1) 106736078 106736081
CFA: 403715(SRD5A2) 403716(SRD5A1) 482155(SRD5A3)
AML: 100463734(SRD5A3) 100466687(SRD5A2) 100472194(SRD5A1)
UMR: 103671605(SRD5A2) 103672741(SRD5A3) 103679225(SRD5A1)
ORO: 101363313(SRD5A1) 101370876(SRD5A3) 101376466(SRD5A2)
FCA: 101086898(SRD5A2) 101090010(SRD5A3) 101098848(SRD5A1)
PTG: 102951833(SRD5A1) 102953790(SRD5A2) 102960215(SRD5A3)
AJU: 106971261(SRD5A1)
BTA: 527024(SRD5A2) 535834(SRD5A3) 614612(SRD5A1)
BOM: 102271230(SRD5A2) 102273138(SRD5A1) 102284607(SRD5A3)
BIU: 109560479(SRD5A3) 109565724(SRD5A2) 109574873(SRD5A1)
PHD: 102326516(SRD5A2) 102328275(SRD5A1) 102331048(SRD5A3)
CHX: 102172667(SRD5A1) 102180581(SRD5A3) 102187232(SRD5A2)
OAS: 100642181(SRD5A1) 100820756(SRD5A2) 101106772(SRD5A3)
SSC: 100518046(SRD5A1) 100525350 397048(SRD5A2)
CFR: 102514136(SRD5A1) 102523042(SRD5A3) 102523831(SRD5A2)
CDK: 105091542(SRD5A3) 105094037(SRD5A1) 105095594(SRD5A2)
BACU: 102998118(SRD5A1) 103005044 103012155(SRD5A3)
LVE: 103070353(SRD5A1) 103084942(SRD5A2) 103087526(SRD5A3)
OOR: 101276021 101284817(SRD5A2) 101287651(SRD5A1) 101290031(SRD5A3)
ECB: 100059582(SRD5A3) 100070655(SRD5A2) 100071450(SRD5A1)
EPZ: 103550080(SRD5A1) 103554975(SRD5A3) 103561662(SRD5A2)
EAI: 106822987(SRD5A1) 106836922(SRD5A3) 106847216(SRD5A2)
MYB: 102242056(SRD5A2) 102257134(SRD5A3) 102260657(SRD5A1)
MYD: 102762730(SRD5A1) 102771502(SRD5A3) 102773080(SRD5A2)
HAI: 109376001(SRD5A1) 109381825(SRD5A3) 109388788(SRD5A2)
RSS: 109437897(SRD5A2) 109451723(SRD5A3) 109453581(SRD5A1)
PALE: 102884992(SRD5A2) 102889165(SRD5A1) 102896891(SRD5A3)
LAV: 100671020(SRD5A3) 100673173(SRD5A1)
MDO: 100017228(SRD5A3) 100018123(SRD5A1) 100031489(SRD5A2)
SHR: 100920954(SRD5A1) 100928836(SRD5A3) 100934924(SRD5A2)
OAA: 100075423(SRD5A3) 100078235(SRD5A2)
GGA: 422750(SRD5A3) 770453(SRD5A1) 772291(SRD5A2)
MGP: 100540890(SRD5A1) 100541554(SRD5A3) 100546745(SRD5A2)
CJO: 107309501(SRD5A1) 107311306(SRD5A2) 107313729(SRD5A3)
APLA: 101792279(SRD5A1) 101796282(SRD5A3) 101799397(SRD5A2)
ACYG: 106030826(SRD5A3) 106036530(SRD5A1) 106049776(SRD5A2)
TGU: 100224163(SRD5A3) 100225484(SRD5A2) 101233999(SRD5A1)
GFR: 102038097(SRD5A2) 102040059(SRD5A1) 102042544(SRD5A3)
FAB: 101808258(SRD5A2) 101812956(SRD5A3) 101814400(SRD5A1)
PHI: 102108406(SRD5A2) 102110867(SRD5A1) 102113098(SRD5A3)
PMAJ: 107200161(SRD5A1) 107201346(SRD5A2) 107202960(SRD5A3)
CCAE: 111925370(SRD5A1) 111926994(SRD5A2) 111928443(SRD5A3)
CCW: 104684391(SRD5A2) 104685924(SRD5A1) 104690628(SRD5A3)
FPG: 101911819(SRD5A1) 101919492(SRD5A2) 101920408(SRD5A3)
FCH: 102046391(SRD5A2) 102049514(SRD5A1) 102059273(SRD5A3)
CLV: 102085278(SRD5A2) 102086070(SRD5A1) 102095131(SRD5A3)
EGZ: 104124808(SRD5A2) 104126190(SRD5A1) 104129459(SRD5A3)
AAM: 106485465(SRD5A2) 106490085(SRD5A3) 106492345(SRD5A1)
ASN: 102379264 102380496(SRD5A1) 102380562(SRD5A2) 102384757
AMJ: 102565754(SRD5A1) 102567202(SRD5A3) 102573116(SRD5A2)
PSS: 102444263(SRD5A3) 102449134(SRD5A1) 102451701(SRD5A2)
CMY: 102936118(SRD5A2) 102936322(SRD5A3) 102940906(SRD5A1)
CPIC: 101931675(SRD5A1) 101937467(SRD5A3) 101939421
ACS: 100551938(srd5a3) 100555660(srd5a1) 100563846(srd5a2) 103282902
PVT: 110076132(SRD5A2) 110078425(SRD5A3) 110080024(SRD5A1)
PBI: 103048475(SRD5A2) 103063410(SRD5A3) 103065332(SRD5A1)
GJA: 107106033(SRD5A3) 107108075(SRD5A2) 107123746(SRD5A1)
XLA: 100049757(srd5a1.S) 108698470(srd5a3.L) 108716702(srd5a2.L) 108717848(srd5a2.S) 379123(srd5a3.S)
XTR: 448586(srd5a1) 549867(srd5a2) 779994(srd5a3)
NPR: 108789853(SRD5A2) 108795133(SRD5A1) 108804033(SRD5A3)
DRE: 550388(srd5a2b) 550398(srd5a2a) 560717(srd5a3) 767715(srd5a1)
IPU: 108258126(srd5a3) 108258997(srd5a2) 108272332(srd5a1)
AMEX: 103036227(srd5a2) 103038993(srd5a1) 103043083 103045498(srd5a3)
TRU: 101063216(srd5a1) 101066856(srd5a2) 105417901(srd5a3)
LCO: 104918211(srd5a2) 104919092(srd5a3) 104922765(srd5a1) 104939523
NCC: 104947078(srd5a3) 104959824
MZE: 101473345(srd5a3) 101475598(srd5a1) 101476244 101484346
OLA: 100125491(srd5a1) 100125532 101156806(srd5a3) 101156869
XMA: 102220105(srd5a1) 102228249 102230435(srd5a2) 102237479(srd5a3)
PRET: 103463835(srd5a3) 103471931 103472068(srd5a1) 103477241
NFU: 107375448(srd5a2) 107383183(srd5a1) 107393391(srd5a3) 107394001
KMR: 108229061 108238724(srd5a1) 108243377(srd5a3) 108248141(srd5a2)
CSEM: 103376703(srd5a3) 103383286 103394093(srd5a1)
LCF: 108879013(srd5a3) 108882308 108885816(srd5a2) 108900396(srd5a1)
SDU: 111220716(srd5a2) 111226375(srd5a3) 111233184(srd5a1) 111237591
HCQ: 109508284(srd5a1) 109516280(srd5a2) 109532109(srd5a3)
BPEC: 110153623 110154923(srd5a3) 110157251(srd5a2) 110167484(srd5a1)
MALB: 109962082(srd5a3) 109971730(srd5a1) 109971818(srd5a2)
SASA: 100196185(s5a2) 106564819(S5A2) 106584121(srd5a3) 106588696(srd5a1)
ELS: 105011840(srd5a3) 105012407(srd5a1) 105029457 105031435
LCM: 102346093(SRD5A1) 102355026(SRD5A2) 102363132(SRD5A3)
CMK: 103178169(srd5a3) 103181748(srd5a2) 103183194(srd5a1)
SKO: 100378021
DME: Dmel_CG7840(CG7840)
DER: 6543492
DPE: 6588751
DSI: Dsimw501_GD23520(Dsim_GD23520)
DWI: 6641644
AAG: 5575734
AME: 102656812
BIM: 100744185
BTER: 100647495
AEC: 105149417
ACEP: 105627262
CFO: 105257288
PCF: 106788533
NVI: 100119448
MDL: 103569697
NVL: 108560909
BMOR: 101735516
PRAP: 110999351
HAW: 110370980
PXY: 105381317
CLEC: 106666251
ZNE: 110834339
CEL: CELE_B0024.13(B0024.13) CELE_F19H6.4(F19H6.4) CELE_F42F12.3(F42F12.3)
BMY: Bm1_06570
SHX: MS3_06000
EGL: EGR_04368
HMG: 100197205
ATH: AT2G16530 AT2G38050(DET2)
LJA: Lj0g3v0256849.1(Lj0g3v0256849.1) Lj3g3v3396900.1(Lj3g3v3396900.1)
DOSA: Os01t0851600-01(Os01g0851600) Os04t0576800-01(Os04g0576800) Os07t0493400-01(Os07g0493400) Os11t0184100-01(Os11g0184100)
ATS: 109743537(LOC109743537) 109764908(LOC109764908)
MNG: MNEG_6120
SCE: YIL049W(DFG10)
ERC: Ecym_4334
KMX: KLMA_70185(DFG10)
NCS: NCAS_0A13460(NCAS0A13460)
NDI: NDAI_0A02580(NDAI0A02580)
TPF: TPHA_0K00940(TPHA0K00940)
TBL: TBLA_0J01440(TBLA0J01440)
TDL: TDEL_0H02090(TDEL0H02090)
KAF: KAFR_0I01850(KAFR0I01850)
PIC: PICST_31592(DFG10)
CAL: CAALFM_C208970CA(DFG10)
CDU: CD36_23150(DFG10)
CAUR: QG37_06040
NTE: NEUTE1DRAFT82283(NEUTE1DRAFT_82283)
ANI: AN4071.2
ANG: ANI_1_1622184(An04g01740) ANI_1_570164(An18g04290)
CNE: CNA03510
CNB: CNBA3370
ABP: AGABI1DRAFT59271(AGABI1DRAFT_59271)
ABV: AGABI2DRAFT224531(AGABI2DRAFT_224531)
MGL: MGL_3451
DFA: DFA_07066
EHI: EHI_197070(92.t00023)
PYO: PY17X_1323400(PY01579)
SMIN: v1.2.019044.t1(symbB.v1.2.019044.t1)
PTI: PHATRDRAFT_17044(DET2)
SPAR: SPRG_09830
LLA: L176238(yfhH)
MUL: MUL_3208
MMI: MMAR_2552
MAB: MAB_2819
NFA: NFA_45190
REQ: REQ_08000
ACTN: L083_3086
TDE: TDE2697
TPED: TPE_0965
BTH: BT_2068
BFR: BF3752
BVU: BVU_1964
BXY: BXY_12340
AFD: Alfi_2922
ASH: AL1_03180
FLM: MY04_0311
 » show all
Taxonomy
Reference
1  [PMID:13673006]
  Authors
LEVY HR, TALALAY P.
  Title
Bacterial oxidation of steroids. II. Studies on the enzymatic mechanism of ring A dehydrogenation.
  Journal
J Biol Chem 234:2014-21 (1959)
Reference
2  [PMID:5907469]
  Authors
Shefer S, Hauser S, Mosbach EH.
  Title
Studies on the biosynthesis of 5-alpha-cholestan-3-beta-ol. I. Cholestenone 5-alpha-reductase of rat liver.
  Journal
J Biol Chem 241:946-52 (1966)
Reference
3  [PMID:1166484]
  Authors
Cheng YJ, Karavolas HJ.
  Title
Properties and subcellular distribution of delta4-steroid (progesterone) 5alpha-reductase in rat anterior pituitary.
  Journal
Steroids 26:57-71 (1975)
DOI:10.1016/0039-128X(75)90006-9
Reference
4  [PMID:1705142]
  Authors
Sargent NS, Habib FK
  Title
Partial purification of human prostatic 5 alpha-reductase (3-oxo-5 alpha-steroid:NADP+ 4-ene-oxido-reductase; EC 1.3.1.22) in a stable and active form.
  Journal
J Steroid Biochem Mol Biol 38:73-7 (1991)
DOI:10.1016/0960-0760(91)90403-R
Reference
5  [PMID:7900170]
  Authors
Quemener E, Amet Y, di Stefano S, Fournier G, Floch HH, Abalain JH
  Title
Purification of testosterone 5 alpha-reductase from human prostate by a four-step chromatographic procedure.
  Journal
Steroids 59:712-8 (1994)
DOI:10.1016/0039-128X(94)90103-1
Reference
6  [PMID:9202401]
  Authors
Poletti A, Celotti F, Rumio C, Rabuffetti M, Martini L
  Title
Identification of type 1 5alpha-reductase in myelin membranes of male and female  rat brain.
  Journal
Mol Cell Endocrinol 129:181-90 (1997)
DOI:10.1016/S0303-7207(97)04056-2
Reference
7  [PMID:9108014]
  Authors
Li J, Biswas MG, Chao A, Russell DW, Chory J
  Title
Conservation of function between mammalian and plant steroid 5alpha-reductases.
  Journal
Proc Natl Acad Sci U S A 94:3554-9 (1997)
DOI:10.1073/pnas.94.8.3554
  Sequence
[ath:AT2G38050]
Reference
8  [PMID:15993049]
  Authors
Rosati F, Bardazzi I, De Blasi P, Simi L, Scarpi D, Guarna A, Serio M, Racchi ML, Danza G.
  Title
5alpha-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the presence of two isoenzymes.
  Journal
J Steroid Biochem Mol Biol 96:287-99 (2005)
DOI:10.1016/j.jsbmb.2005.04.035
  Sequence
[sly:543801]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.22
IUBMB Enzyme Nomenclature: 1.3.1.22
ExPASy - ENZYME nomenclature database: 1.3.1.22
BRENDA, the Enzyme Database: 1.3.1.22
CAS: 37255-34-8

KEGG   ENZYME: 1.3.1.94Help
Entry
EC 1.3.1.94                 Enzyme                                 

Name
polyprenol reductase;
SRD5A3 (gene name);
DFG10 (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase
Reaction(IUBMB)
ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH + H+
Substrate
ditrans,polycis-dolichol;
NADP+ [CPD:C00006]
Product
ditrans,polycis-polyprenol;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs in the reverse direction with reduction of the terminal double bond next to the alcohol group. Isolated from human fetal brain tissue but present in all eukaryotes. In mammalian cells dolichols are predominantly 18-21 isoprene units in length.
History
EC 1.3.1.94 created 2012
Orthology
K12345  3-oxo-5-alpha-steroid 4-dehydrogenase 3
Genes
HSA: 79644(SRD5A3)
PTR: 471241(SRD5A3)
PPS: 100987485(SRD5A3)
GGO: 101127484(SRD5A3)
PON: 100461714(SRD5A3)
NLE: 100604898(SRD5A3)
MCC: 696381(SRD5A3)
MCF: 102135568(SRD5A3)
CSAB: 103235668(SRD5A3)
RRO: 104662017(SRD5A3)
RBB: 108531594(SRD5A3)
CJC: 100409457(SRD5A3)
SBQ: 101035698(SRD5A3)
MMU: 57357(Srd5a3)
RNO: 305291(Srd5a3)
CGE: 100770660(Srd5a3)
NGI: 103734389(Srd5a3)
HGL: 101726767(Srd5a3)
CCAN: 109698967(Srd5a3)
OCU: 100346041(SRD5A3)
CFA: 482155(SRD5A3)
AML: 100463734(SRD5A3)
UMR: 103672741(SRD5A3)
ORO: 101370876(SRD5A3)
FCA: 101090010(SRD5A3)
PTG: 102960215(SRD5A3)
BTA: 535834(SRD5A3)
BOM: 102284607(SRD5A3)
BIU: 109560479(SRD5A3)
PHD: 102331048(SRD5A3)
CHX: 102180581(SRD5A3)
OAS: 101106772(SRD5A3)
SSC: 100525350
CFR: 102523042(SRD5A3)
CDK: 105091542(SRD5A3)
BACU: 103012155(SRD5A3)
LVE: 103087526(SRD5A3)
OOR: 101276021 101290031(SRD5A3)
ECB: 100059582(SRD5A3)
EPZ: 103554975(SRD5A3)
EAI: 106836922(SRD5A3)
MYB: 102257134(SRD5A3)
MYD: 102771502(SRD5A3)
HAI: 109381825(SRD5A3)
RSS: 109451723(SRD5A3)
PALE: 102896891(SRD5A3)
LAV: 100671020(SRD5A3)
TMU: 101348372
MDO: 100017228(SRD5A3)
SHR: 100928836(SRD5A3)
OAA: 100075423(SRD5A3)
GGA: 422750(SRD5A3)
MGP: 100541554(SRD5A3)
CJO: 107313729(SRD5A3)
APLA: 101796282(SRD5A3)
ACYG: 106030826(SRD5A3)
TGU: 100224163(SRD5A3)
GFR: 102042544(SRD5A3)
FAB: 101812956(SRD5A3)
PHI: 102113098(SRD5A3)
PMAJ: 107202960(SRD5A3)
CCAE: 111928443(SRD5A3)
CCW: 104690628(SRD5A3)
FPG: 101920408(SRD5A3)
FCH: 102059273(SRD5A3)
CLV: 102095131(SRD5A3)
EGZ: 104129459(SRD5A3)
AAM: 106490085(SRD5A3)
AMJ: 102567202(SRD5A3)
PSS: 102444263(SRD5A3)
CMY: 102936322(SRD5A3)
CPIC: 101937467(SRD5A3)
ACS: 100551938(srd5a3) 103282902
PVT: 110078425(SRD5A3)
PBI: 103063410(SRD5A3)
GJA: 107106033(SRD5A3)
XLA: 108698470(srd5a3.L) 379123(srd5a3.S)
XTR: 779994(srd5a3)
NPR: 108804033(SRD5A3)
DRE: 560717(srd5a3)
SRX: 107718431(srd5a3) 107755245
CCAR: 109066982(srd5a3)
IPU: 108258126(srd5a3)
AMEX: 103045498(srd5a3)
TRU: 105417901(srd5a3)
LCO: 104919092(srd5a3)
NCC: 104947078(srd5a3)
MZE: 101473345(srd5a3)
OLA: 101156806(srd5a3)
XMA: 102237479(srd5a3)
PRET: 103463835(srd5a3)
NFU: 107393391(srd5a3)
KMR: 108243377(srd5a3)
CSEM: 103376703(srd5a3)
LCF: 108879013(srd5a3)
SDU: 111226375(srd5a3)
HCQ: 109532109(srd5a3)
BPEC: 110154923(srd5a3)
MALB: 109962082(srd5a3)
SASA: 106584121(srd5a3)
OTW: 112249150(srd5a3)
ELS: 105011840(srd5a3)
LCM: 102363132(SRD5A3)
CMK: 103178169(srd5a3)
SPU: 579990
APLC: 110989371
DME: Dmel_CG7840(CG7840)
DER: 6543492
DPE: 6588751
DSI: Dsimw501_GD23520(Dsim_GD23520)
DWI: 6641644
AAG: 5575734
AME: 102656812
BIM: 100744185
BTER: 100647495
AEC: 105149417
ACEP: 105627262
CFO: 105257288
PCF: 106788533
NVI: 100119448
MDL: 103569697
NVL: 108560909
BMOR: 101735516
PRAP: 110999351
HAW: 110370980
PXY: 105381317
CLEC: 106666251
ZNE: 110834339
FCD: 110851178
CEL: CELE_B0024.13(B0024.13)
CBR: CBG09584
CRG: 105321676
MYI: 110466723
OBI: 106867229
SHX: MS3_06000
EGL: EGR_04368
EPA: 110244800
ADF: 107355083
AQU: 105312044
ATH: AT2G16530
CRB: 17891741
THJ: 104807290
CPAP: 110808172
CIT: 102619924
GMX: 100814660
VRA: 106780535
CCAJ: 109799194
CAM: 101499200
LJA: Lj3g3v3396900.1(Lj3g3v3396900.1)
LANG: 109325126
PPER: 18766685
PMUM: 103335594
PAVI: 110750327
ZJU: 107426582
CSV: 101215230
CMO: 103488097
MCHA: 111007527
CMAX: 111469837
CMOS: 111441221
CPEP: 111793137
JCU: 105628630
HBR: 110656001
SLY: 101261171
SPEN: 107007858
SOT: 102597141
CANN: 107840488
NSY: 104249824
NTO: 104117912
SIND: 105169751
OEU: 111410560
CCAV: 112528787
DCR: 108203137
BVG: 104884739
SOE: 110792437
NNU: 104607497
OSA: 4336740
DOSA: Os04t0576800-01(Os04g0576800) Os07t0493400-01(Os07g0493400)
OBR: 102708235
BDI: 100834872
ATS: 109764908(LOC109764908)
SBI: 8155280
ZMA: 100502028
SITA: 101786400
PDA: 103699632
EGU: 105043343
MUS: 103984650
DCT: 110110583
PEQ: 110019516
ATR: 18444657
PPP: 112294840
APRO: F751_0034
SCE: YIL049W(DFG10)
ERC: Ecym_4334
KMX: KLMA_70185(DFG10)
NCS: NCAS_0A13460(NCAS0A13460)
NDI: NDAI_0A02580(NDAI0A02580)
TPF: TPHA_0K00940(TPHA0K00940)
TBL: TBLA_0J01440(TBLA0J01440)
TDL: TDEL_0H02090(TDEL0H02090)
KAF: KAFR_0I01850(KAFR0I01850)
PIC: PICST_31592(DFG10)
CAL: CAALFM_C208970CA(DFG10)
CDU: CD36_23150(DFG10)
CAUR: QG37_06040
NCR: NCU00387
NTE: NEUTE1DRAFT82283(NEUTE1DRAFT_82283)
MGR: MGG_13163
SSCK: SPSK_02576
MAW: MAC_08655
MAJ: MAA_05987
CMT: CCM_01790
MBE: MBM_01200
ANI: AN4071.2
ANG: ANI_1_570164(An18g04290)
ABE: ARB_05619
TVE: TRV_07203
PTE: PTT_08450
DFA: DFA_07066
PYO: PY17X_1323400(PY01579)
SPAR: SPRG_09830
 » show all
Taxonomy
Reference
1  [PMID:8486680]
  Authors
Sagami H, Kurisaki A, Ogura K
  Title
Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver.
  Journal
J Biol Chem 268:10109-13 (1993)
  Sequence
[rno:305291]
Reference
2  [PMID:20637498]
  Authors
Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blumel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG
  Title
SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.
  Journal
Cell 142:203-17 (2010)
DOI:10.1016/j.cell.2010.06.001
  Sequence
[hsa:79644] [mmu:57357] [sce:YIL049W]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.94
IUBMB Enzyme Nomenclature: 1.3.1.94
ExPASy - ENZYME nomenclature database: 1.3.1.94
BRENDA, the Enzyme Database: 1.3.1.94

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