KEGG   ENZYME: 1.3.1.24Help
Entry
EC 1.3.1.24                 Enzyme                                 

Name
biliverdin reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
bilirubin:NAD(P)+ oxidoreductase
Reaction(IUBMB)
bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+ [RN:R02391 R02393]
Reaction(KEGG)
Substrate
bilirubin [CPD:C00486];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
biliverdin [CPD:C00500];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.3.1.24 created 1972
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00214  biliverdin reductase
K05901  biliverdin reductase / flavin reductase
Genes
HSA: 644(BLVRA) 645(BLVRB)
PTR: 456039(BLVRB) 463366(BLVRA)
PPS: 100976517(BLVRA) 100989093(BLVRB)
GGO: 101142015(BLVRB) 101145695(BLVRA)
PON: 100434664(BLVRA) 100446184(BLVRB)
NLE: 100581836(BLVRA) 100587172(BLVRB)
MCC: 700980(BLVRA) 703020(BLVRB)
MCF: 102136439(BLVRA) 102142962(BLVRB)
CSAB: 103226154(BLVRA) 103234707(BLVRB)
RRO: 104676113(BLVRB) 104676702(BLVRA)
RBB: 108539085(BLVRB) 108544019(BLVRA)
CJC: 100391206(BLVRB) 100404177(BLVRA)
SBQ: 101043206(BLVRB) 101051509(BLVRA)
MMU: 109778(Blvra) 233016(Blvrb)
RNO: 116599(Blvra) 292737(Blvrb)
CGE: 100751522(Blvra) 100768929(Blvrb)
NGI: 103733050(Blvra) 103750766(Blvrb)
HGL: 101697384(Blvrb) 101722954(Blvra)
CCAN: 109682461(Blvra) 109688540(Blvrb)
OCU: 100340115(BLVRB) 100346798(BLVRA)
TUP: 102476728(BLVRA) 102490802(BLVRB)
CFA: 475867(BLVRA) 476456(BLVRB)
AML: 100467254(BLVRB) 100474311(BLVRA)
UMR: 103661047(BLVRB) 103674578(BLVRA)
ORO: 101371765(BLVRB) 101385773(BLVRA)
FCA: 101088735(BLVRA) 101092315(BLVRB)
PTG: 102957548(BLVRA) 102957700(BLVRB)
AJU: 106977737(BLVRA) 106979604(BLVRB)
BTA: 281650(BLVRB) 504596(BLVRA)
BOM: 102277747(BLVRB) 102279089(BLVRA)
BIU: 109557549(BLVRA) 109572681(BLVRB)
PHD: 102331348 102344863(BLVRA)
CHX: 102186555(BLVRA) 102187796(BLVRB)
OAS: 101118353(BLVRA) 101119750(BLVRB)
SSC: 100515289(BLVRA) 100625219(BLVRB)
CFR: 102503539(BLVRA) 102522968(BLVRB)
CDK: 105092327(BLVRA) 105093394(BLVRB)
BACU: 103006819(BLVRA) 103014515(BLVRB)
LVE: 103073162(BLVRA) 103082225(BLVRB)
OOR: 101269881(BLVRB) 101285825(BLVRA)
ECB: 100064761(BLVRA) 100068145(BLVRB)
EPZ: 103555616(BLVRA) 103560493(BLVRB)
EAI: 106839159(BLVRA) 106843297(BLVRB)
MYB: 102243524(BLVRA) 102251416(BLVRB)
MYD: 102759928(BLVRB) 102775325(BLVRA)
HAI: 109374869(BLVRB) 109375451(BLVRA)
RSS: 109438807(BLVRA) 109458110(BLVRB)
PALE: 102879551(BLVRB) 102892087(BLVRA)
LAV: 100660266(BLVRA) 100665167(BLVRB)
MDO: 100017892(BLVRB) 100029544(BLVRA)
SHR: 100915926(BLVRA) 100930351(BLVRB)
OAA: 100073853(BLVRB) 100076047(BLVRA) 100681226
GGA: 420776(BLVRA)
MGP: 100303679(BLVRB) 100542635(BLVRA)
CJO: 107309812(BLVRA)
APLA: 101793149(BLVRA)
ACYG: 106042895(BLVRA)
TGU: 100224786(BLVRA) 100231163
GFR: 102043974(BLVRA)
FAB: 101818701(BLVRA)
PHI: 102102005(BLVRA) 102113532(BLVRB)
PMAJ: 107200264(BLVRA)
CCAE: 111923662(BLVRA) 111943368(BLVRB)
CCW: 104688918(BLVRA)
FPG: 101924606(BLVRA)
FCH: 102055391(BLVRA)
CLV: 102097224(BLVRA) 110356600(BLVRB)
EGZ: 104125204(BLVRA)
AAM: 106493723(BLVRB) 106495280(BLVRA)
ASN: 102371445(BLVRA) 102387963(BLVRB)
AMJ: 102567480(BLVRA) 102574563(BLVRB)
PSS: 102463244(BLVRA)
CMY: 102933712(BLVRA)
CPIC: 101948417(BLVRB) 101950655(BLVRA)
ACS: 100564394(blvra) 100564796(blvrb)
PVT: 110075662(BLVRB) 110081583(BLVRA)
PBI: 103049956(BLVRA) 103053858(BLVRB)
GJA: 107107369(BLVRB) 107109993(BLVRA) 107123558
XLA: 100137674(blvra.L) 443881(blvrb.L)
XTR: 100124834(blvrb) 448743(blvra)
NPR: 108791950(BLVRB) 108797466(BLVRA)
DRE: 436959(blvrb) 767661(blvra)
SRX: 107713657(blvra) 107717620(blvrb) 107757787
SGH: 107599292 107600218(blvra) 107602119(blvrb)
IPU: 100528810(blvra) 108264654(blvrb)
AMEX: 103037727(blvra) 103040962(blvrb)
TRU: 101061122(blvrb) 101070243(blvra)
LCO: 104927805(blvrb) 104930153(blvra) 109140017
NCC: 104965039(blvrb)
MZE: 101473603(blvra) 101484658(blvrb)
OLA: 101163919(blvrb) 101175193(blvra)
XMA: 102228591(blvrb) 102229366(blvra)
PRET: 103475161(blvrb) 103479218(blvra)
NFU: 107379787(blvrb) 107384337(blvra)
KMR: 108247879(blvrb)
CSEM: 103377891(blvrb)
SDU: 111216890(blvrb) 111233913(blvra)
HCQ: 109515486(blvra) 109529422(blvrb)
BPEC: 110168032(blvra) 110172712(blvrb)
MALB: 109963258(blvrb) 109971399(blvra)
SASA: 106569211(blvra) 106580739(blvrb) 106599287 106612705(BLVRB)
ELS: 105023068(blvrb) 105024256(blvra)
SFM: 108928749(blvrb) 108934031(blvra)
LCM: 102358034(BLVRB)
CMK: 103173572(blvrb) 103181265(blvra)
CIN: 100185152
DSI: Dsimw501_GD20759(Dsim_GD20759)
MDE: 101892800
AAG: 5565330
BIM: 100749252
BTER: 100646178
AEC: 105144797
ACEP: 105624072
PBAR: 105426660
HST: 105187135
DQU: 106744067
CFO: 105252649
LHU: 105674651
PGC: 109861802
PCF: 106793889
NVI: 100113525
TCA: 664311
DPA: 109534878
NVL: 108556546
BMOR: 101736226
PMAC: 106708927
PRAP: 111001233
HAW: 110382146
PXY: 105393340
API: 100168586(Blvrb) 100574136
DNX: 107162985
ZNE: 110828593
CRG: 105324708
MYI: 110447723
OBI: 106880542
EPA: 110249688
ADF: 107348181
SYN: slr1784(bvdR)
SYZ: MYO_12210(bvdR)
SYY: SYNGTS_0221(bvdR)
SYT: SYNGTI_0221(bvdR)
SYS: SYNPCCN_0221(bvdR)
SYQ: SYNPCCP_0221(bvdR)
SYJ: D082_05120(bvdR)
SYP: SYNPCC7002_A2324(bvdR)
CYA: CYA_2461
CYB: CYB_1431
LET: O77CONTIG1_00600(ydgJ)
HHG: XM38_017200(ydgJ)
MAR: MAE_61890(bvdR)
MPK: VL20_2197
CYL: AA637_13445(bvdR)
CYT: cce_1608(bvdR)
TER: Tery_0913
ARP: NIES39_B00110(bvdR)
GVI: gvip105(bvdR)
GLJ: GKIL_1362(bvdR)
ANA: alr4149(bvdR)
AVA: Ava_0755
NAZ: Aazo_0182
CALH: IJ00_21030
CTHE: Chro_2639
CEO: ETSB_0923(bvdR)
 » show all
Taxonomy
Reference
1  [PMID:4378982]
  Authors
Singleton JW, Laster L.
  Title
Biliverdin reductase of guinea pig liver.
  Journal
J Biol Chem 240:4780-9 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.24
IUBMB Enzyme Nomenclature: 1.3.1.24
ExPASy - ENZYME nomenclature database: 1.3.1.24
BRENDA, the Enzyme Database: 1.3.1.24
CAS: 9074-10-6

KEGG   ENZYME: 1.5.1.30Help
Entry
EC 1.5.1.30                 Enzyme                                 

Name
flavin reductase (NADPH);
NADPH:flavin oxidoreductase;
riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase;
flavin mononucleotide reductase;
flavine mononucleotide reductase;
FMN reductase (NADPH);
NADPH-dependent FMN reductase;
NADPH-flavin reductase;
NADPH-FMN reductase;
NADPH-specific FMN reductase;
riboflavin mononucleotide reductase;
riboflavine mononucleotide reductase;
NADPH2 dehydrogenase (flavin);
NADPH2:riboflavin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
reduced-riboflavin:NADP+ oxidoreductase
Reaction(IUBMB)
reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]
Reaction(KEGG)
R05707;
(other) R09520
Show
Substrate
reduced riboflavin [CPD:C01007];
NADP+ [CPD:C00006]
Product
riboflavin [CPD:C00255];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH.
History
EC 1.5.1.30 created 1982 as EC 1.6.8.2, transferred 2002 to EC 1.5.1.30, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K05901  biliverdin reductase / flavin reductase
Genes
HSA: 645(BLVRB)
PTR: 456039(BLVRB)
PPS: 100989093(BLVRB)
GGO: 101142015(BLVRB)
PON: 100446184(BLVRB)
NLE: 100587172(BLVRB)
MCC: 703020(BLVRB)
MCF: 102142962(BLVRB)
CSAB: 103234707(BLVRB)
RRO: 104676113(BLVRB)
RBB: 108539085(BLVRB)
CJC: 100391206(BLVRB)
SBQ: 101043206(BLVRB)
MMU: 233016(Blvrb)
RNO: 292737(Blvrb)
CGE: 100768929(Blvrb)
NGI: 103750766(Blvrb)
HGL: 101697384(Blvrb)
CCAN: 109688540(Blvrb)
OCU: 100340115(BLVRB)
TUP: 102490802(BLVRB)
CFA: 476456(BLVRB)
AML: 100467254(BLVRB)
UMR: 103661047(BLVRB)
ORO: 101371765(BLVRB)
FCA: 101092315(BLVRB)
PTG: 102957700(BLVRB)
AJU: 106979604(BLVRB)
BTA: 281650(BLVRB)
BOM: 102277747(BLVRB)
BIU: 109572681(BLVRB)
CHX: 102187796(BLVRB)
OAS: 101119750(BLVRB)
SSC: 100625219(BLVRB)
CFR: 102522968(BLVRB)
CDK: 105093394(BLVRB)
BACU: 103014515(BLVRB)
LVE: 103082225(BLVRB)
OOR: 101269881(BLVRB)
ECB: 100068145(BLVRB)
EPZ: 103560493(BLVRB)
EAI: 106843297(BLVRB)
MYB: 102251416(BLVRB)
MYD: 102759928(BLVRB)
HAI: 109374869(BLVRB)
RSS: 109458110(BLVRB)
PALE: 102879551(BLVRB)
LAV: 100665167(BLVRB)
TMU: 101354315
MDO: 100017892(BLVRB)
SHR: 100930351(BLVRB)
OAA: 100073853(BLVRB)
MGP: 100303679(BLVRB)
PHI: 102113532(BLVRB)
CCAE: 111943368(BLVRB)
CLV: 110356600(BLVRB)
AAM: 106493723(BLVRB)
ASN: 102387963(BLVRB)
AMJ: 102574563(BLVRB)
CPIC: 101948417(BLVRB)
ACS: 100564796(blvrb)
PVT: 110075662(BLVRB)
PBI: 103053858(BLVRB)
GJA: 107107369(BLVRB)
XLA: 443881(blvrb.L)
XTR: 100124834(blvrb)
NPR: 108791950(BLVRB)
DRE: 436959(blvrb)
SRX: 107717620(blvrb)
SGH: 107602119(blvrb)
IPU: 108264654(blvrb)
AMEX: 103040962(blvrb)
TRU: 101061122(blvrb)
LCO: 104927805(blvrb) 109140017
NCC: 104965039(blvrb)
MZE: 101484658(blvrb)
OLA: 101163919(blvrb)
XMA: 102228591(blvrb)
PRET: 103475161(blvrb)
NFU: 107379787(blvrb)
KMR: 108247879(blvrb)
CSEM: 103377891(blvrb)
LCF: 108876241(blvrb)
SDU: 111216890(blvrb)
HCQ: 109529422(blvrb)
BPEC: 110172712(blvrb)
MALB: 109963258(blvrb)
SASA: 106580739(blvrb) 106612705(BLVRB)
ELS: 105023068(blvrb)
SFM: 108928749(blvrb)
LCM: 102358034(BLVRB)
CMK: 103173572(blvrb)
CIN: 100185152
DSI: Dsimw501_GD20759(Dsim_GD20759)
MDE: 101892800
AAG: 5565330
BIM: 100749252
BTER: 100646178
AEC: 105144797
ACEP: 105624072
PBAR: 105426660
HST: 105187135
DQU: 106744067
CFO: 105252649
LHU: 105674651
PGC: 109861802
PCF: 106793889
NVI: 100113525
TCA: 664311
DPA: 109534878
NVL: 108556546
BMOR: 101736226
PMAC: 106708927
PRAP: 111001233
HAW: 110382146
PXY: 105393340
API: 100168586(Blvrb) 100574136
DNX: 107162985
ZNE: 110828593
 » show all
Taxonomy
Reference
1  [PMID:3453680]
  Authors
Yubisui T, Tamura M, Takeshita M.
  Title
Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes.
  Journal
Biochem Int 15:1-8 (1987)
Reference
2  [PMID:10620517]
  Authors
Cunningham O, Gore MG, Mantle TJ
  Title
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).
  Journal
Biochem J 345 Pt 2:393-9 (2000)
  Sequence
[hsa:645]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.30
IUBMB Enzyme Nomenclature: 1.5.1.30
ExPASy - ENZYME nomenclature database: 1.5.1.30
BRENDA, the Enzyme Database: 1.5.1.30
CAS: 56626-29-0

DBGET integrated database retrieval system