KEGG   ENZYME: 1.3.1.25Help
Entry
EC 1.3.1.25                 Enzyme                                 

Name
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase;
3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase;
3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase;
dihydrodihydroxybenzoate dehydrogenase;
DHBDH;
cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase;
2-hydro-1,2-dihydroxybenzoate dehydrogenase;
cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase;
dihydrodihydroxybenzoate dehydrogenase;
(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+ [RN:R00813]
Reaction(KEGG)
Substrate
(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate [CPD:C06321];
NAD+ [CPD:C00003]
Product
catechol [CPD:C00090];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.3.1.25 created 1976, modified 2004 (EC 1.3.1.55 created 1999, incorporated 2004)
Pathway
ec00362  Benzoate degradation
ec00364  Fluorobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05783  dihydroxycyclohexadiene carboxylate dehydrogenase
Genes
EFE: EFER_1485(benD)
KPN: KPN_01869
KPU: KP1_2934
KPM: KPHS_28390
KPP: A79E_2376
KPH: KPNIH24_14210(benD)
KPZ: KPNIH27_13570(benD)
KPV: KPNIH29_14240(benD)
KPW: KPNIH30_14505(benD)
KPY: KPNIH31_13520(benD)
KPG: KPNIH32_14400(benD)
KPC: KPNIH10_14040(benD)
KPQ: KPR0928_14020(benD)
KPE: KPK_2488(cbeD)
KPO: KPN2242_12265(benD)
KPR: KPR_2933(benD)
KPJ: N559_2421
KPI: D364_09585(benD)
KPX: PMK1_04210(lvr)
KPB: FH42_05420(benD)
KPNE: KU54_012115(benD)
KPNU: LI86_12050(benD)
KPNK: BN49_2969(benD)
KVA: Kvar_2435
KPK: A593_24210(benD)
KVD: KR75_22145(benD)
KVQ: SP68_02890(benD)
KOC: AB185_22235(benD)
KQU: AVR78_18380(benD)
EAE: EAE_19880(benD)
EAR: CCG29904
KQV: B8P98_13160(benD)
CFAR: CI104_13175(benD)
CIR: C2U53_22220(benD)
ROR: RORB6_06755(benD)
RON: TE10_13830(benD)
RPLN: B1209_13860(benD)
PGE: LG71_16210(benD)
EBF: D782_2133
SMAF: D781_2850
SERM: CLM71_14595(benD)
XSA: SB85_10140(benD)
PSD: DSC_14910(benD)
VNA: PN96_18365(benD)
VEJ: VEJY3_17926(benD)
PAE: PA2515(xylL)
PAEV: N297_2586
PAEI: N296_2586
PAU: PA14_32130(xylL)
PAP: PSPA7_2722(xylL)
PAG: PLES_27801(xylL)
PAF: PAM18_2524(benD)
PNC: NCGM2_3520(benD)
PAEB: NCGM1900_4012(benD)
PDK: PADK2_12670(benD)
PSG: G655_12450(benD)
PRP: M062_13075(benD)
PAEP: PA1S_13070(benD)
PAEM: U769_12650(benD)
PAEL: T223_14270(benD)
PAEU: BN889_02739(benD)
PAEG: AI22_20850(benD)
PAEC: M802_2583
PAEO: M801_2451
PMK: MDS_4167
PRE: PCA10_30910(benD)
PPSE: BN5_3608(benD)
PCQ: PcP3B5_23360(lvr)
PPU: PP_3164(benD)
PPF: Pput_2551
PPT: PPS_2762
PPB: PPUBIRD1_2569(benD)
PPI: YSA_10652
PPX: T1E_1059(benD)
PPUH: B479_13460(benD)
PPUT: L483_17645(benD)
PPUN: PP4_25400(benD) PP4_48180(benD)
PPUD: DW66_3021
PMON: X969_13160(benD)
PMOT: X970_12805(benD)
PFL: PFL_3855(xylL)
PPRC: PFLCHA0_c39130(xylL)
PPRO: PPC_3951(benD)
PFE: PSF113_2894(benD)
PFN: HZ99_02920(benD)
PFX: A7318_13915(benD)
PMAN: OU5_6167(xylL)
PAZO: AYR47_21845(benD)
PEN: PSEEN3140(benD)
PSA: PST_1670(benD)
PSR: PSTAA_1698(benD)
PSC: A458_09170(benD)
PSJ: PSJM300_08880(benD)
PSTU: UIB01_13630(benD)
PBM: CL52_07430(benD)
PPUU: PputUW4_03254(xylL)
PDR: H681_11365(benD)
PSV: PVLB_12230(benD)
PKC: PKB_2103(xylL)
PCH: EY04_20395(benD)
PCP: JM49_10825(benD)
PFZ: AV641_09800(benD)
PLQ: AA042_19050(benD)
PSES: PSCI_4806(benD)
PSEM: TO66_21090(benD)
PPSY: AOC04_06645(benD)
PSOS: POS17_3976(benD)
PFK: PFAS1_22860(benD)
PPSL: BJP27_02335(benD)
PSET: THL1_2895
PSIL: PMA3_10990(benD)
AVN: Avin_08620(benD)
AVL: AvCA_08620(benD)
AVD: AvCA6_08620(benD)
ACX: Achr_32810(benD)
PSO: PSYCG_06665(benD)
PALI: A3K91_1588
ACB: A1S_1212
ABY: ABAYE2558(benD)
ABN: AB57_1347
ABX: ABK1_1644
ABH: M3Q_1568
ABAD: ABD1_12210(benD)
ABAZ: P795_11430
ABAU: IX87_04590
ABAA: IX88_08130
ACC: BDGL_000463(benD)
ACD: AOLE_13350(benD)
ACI: ACIAD1439(benD)
ASJ: AsACE_CH01477(benD)
MHC: MARHY0281(benD)
MAD: HP15_1108
MPQ: ABA45_01255(benD)
MARI: ACP86_12000(benD)
AMG: AMEC673_15500(benD)
CYQ: Q91_2245
CZA: CYCME_2563(benD)
HHU: AR456_17680(benD)
HSI: BOX17_05810(benD)
HHH: CLM76_07040(benD)
HBE: BEI_1519
APAC: S7S_13320
MARS: A8C75_10510(benD)
OCE: GU3_01775
ZDF: AN401_00165(benD)
PSE: NH8B_1753(benD)
RSC: RCFBP_11859(benD)
RSL: RPSI07_1884(benD)
RPI: Rpic_1367
RMN: TK49_11665(benD)
REH: H16_A1960(benD)
CNC: CNE_1c19300(benD)
CUH: BJN34_08575(benD)
RME: Rmet_4885(benD)
CCUP: BKK81_23220(benD)
CUP: BKK80_33070(benD)
CUU: BKK79_23955(benD)
BMA: BMAA0184(benD)
BMV: BMASAVP1_1357(benD)
BML: BMA10229_1552(benD)
BMN: BMA10247_A0212(benD)
BMAL: DM55_3534
BMAE: DM78_4623
BMAQ: DM76_4231
BMAI: DM57_14455(benD)
BMAF: DM51_3935
BMAZ: BM44_3496
BMAB: BM45_4332
BPS: BPSS1906(benD)
BPM: BURPS1710b_A1002(benD)
BPL: BURPS1106A_A2584(benD)
BPD: BURPS668_A2728(benD)
BPSE: BDL_5312
BPSM: BBQ_4224
BPSU: BBN_5371
BPSD: BBX_4477
BPZ: BP1026B_II2045(benD)
BPK: BBK_4645
BPSH: DR55_5828
BPSA: BBU_4103
BPSO: X996_5626
BUT: X994_5189
BTQ: BTQ_3763
BTJ: BTJ_4794
BTZ: BTL_5580
BTD: BTI_5084
BTV: BTHA_4621
BTHE: BTN_5251
BTHM: BTRA_5521
BTHA: DR62_5380(benD)
BTHL: BG87_5596
BOK: DM82_6196
BOC: BG90_4468
BVE: AK36_5311
BCN: Bcen_1303
BCEN: DM39_5094
BCEW: DM40_5132
BCEO: I35_7537
BAM: Bamb_6581
BMU: Bmul_3241
BMK: DM80_4620
BMUL: NP80_3313
BCED: DM42_7057
BCEP: APZ15_36345(benD)
BDL: AK34_5715
BPYR: ABD05_32070(benD)
BCON: NL30_37450(benD)
BUB: BW23_4425
BDF: WI26_27680(benD)
BLAT: WK25_16340(benD)
BTEI: WS51_27265(benD)
BSEM: WJ12_16745(benD)
BPSL: WS57_00510(benD)
BMEC: WJ16_18210(benD)
BSTG: WT74_22610(benD)
BSTL: BBJ41_36465(benD)
BGO: BM43_5498
BUK: MYA_5341
BUL: BW21_4619
BUD: AQ610_29995(benD)
BUZ: AYM40_26005(benD)
BUM: AXG89_16415(benD)
BXE: Bxe_B0912(benD)
BXB: DR64_6233
BPH: Bphy_5349
PSPW: BJG93_32100(benD)
PARB: CJU94_35245(benD) CJU94_37920(benD)
PHS: C2L64_29825(benD) C2L64_48515(benD)
PTER: C2L65_18575(benD)
BPT: Bpet1396(benD)
BHO: D560_1121
BHM: D558_1108
BTRM: SAMEA390648701944(benD)
ACHR: C2U31_10450(benD)
AFA: UZ73_17880(benD)
AFQ: AFA_08575(benD)
PNA: Pnap_2109
ACRA: BSY15_1216
CSER: CCO03_07070(benD)
HSE: Hsero_1311(cbeD)
HSZ: ACP92_06560(benD)
HRB: Hrubri_1137(cbeD)
MASW: AM586_16570(benD)
DAR: Daro_2781
THK: CCZ27_03210(benD) CCZ27_16240(benD)
AMIH: CO731_00666(ydaD)
PHT: BLM14_21520(benD)
SFD: USDA257_c54420(benD)
EAD: OV14_a1474(fabG2)
EAH: FA04_27030(benD)
RHK: Kim5_CH01085(benD)
XAU: Xaut_4355
MET: M446_1327
MNO: Mnod_2371
PDE: Pden_1180
PCON: B0A89_14340(benD)
PZH: CX676_12390(benD)
CEH: CEW89_02920(benD)
CON: TQ29_16490(benD)
RMM: ROSMUCSMR3_03736(lvr)
NRE: BES08_19580(benD)
SWI: Swit_2636
SPHD: HY78_12335(benD)
SPHM: G432_15085(benD)
SPHR: BSY17_105
SPHT: K426_21224(benD)
SYA: A6768_16780(benD)
BLAS: BSY18_3981
RGI: RGI145_20865(benD)
AZL: AZL_a07370(benD)
CGL: NCgl2323(benD)
CGB: cg2640(benD)
CGU: WA5_2323(BenD)
CGT: cgR_2288
CGS: C624_11685(benD)
CGG: C629_11695(benD)
CGM: cgp_2640(benD)
CGJ: AR0_11525(benD)
CGQ: CGLAR1_11375(benD)
CGX: SB89_11180(benD)
CEF: CE2308
CHN: A605_11140(benD)
CCN: H924_10135(benD)
CMD: B841_10265(benD)
CII: CIMIT_11045(benD)
CMQ: B840_09755(xylL)
CDX: CDES_10945(benD)
CSTA: CSTAT_12750(benD)
CCJZ: ccrud_10715(benD)
CAMG: CAMM_12485(benD)
BFV: C628_11665(benD)
RHA: RHA1_ro02387(benD)
ROP: ROP_21010(benD)
RPY: Y013_13600(benD)
RAV: AAT18_24450(benD)
RRZ: CS378_14030(benD)
RQI: C1M55_27410(benD)
RHQ: IM25_04945(benD)
RHOD: AOT96_07380(benD)
RRT: 4535765_04644(benD)
DPC: A6048_05505(benD)
DLU: A6035_05570(benD)
ARU: ASPU41_14625(benD)
ARN: CGK93_10510(benD)
ACRY: AC20117_04985(benD)
PSUL: AU252_22710(benD)
KPL: KPaMU14_10935(benD)
KFV: AS188_00025(benD)
SHT: KO02_15975(benD)
 » show all
Taxonomy
Reference
1  [PMID:4341530]
  Authors
Reiner AM.
  Title
Metabolism of aromatic compounds in bacteria. Purification and properties of the catechol-forming enzyme, 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid (NAD + ) oxidoreductase (decarboxylating).
  Journal
J Biol Chem 247:4960-5 (1972)
Reference
2  [PMID:1740120]
  Authors
Neidle E, Hartnett C, Ornston LN, Bairoch A, Rekik M, Harayama S.
  Title
cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily.
  Journal
Eur J Biochem 204:113-20 (1992)
DOI:10.1111/j.1432-1033.1992.tb16612.x
  Sequence
[aci:ACIAD1439]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.25
IUBMB Enzyme Nomenclature: 1.3.1.25
ExPASy - ENZYME nomenclature database: 1.3.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.25
BRENDA, the Enzyme Database: 1.3.1.25
CAS: 60496-16-4

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