KEGG   ENZYME: 1.3.1.45Help
Entry
EC 1.3.1.45                 Enzyme                                 

Name
2'-hydroxyisoflavone reductase;
NADPH:2'-hydroxyisoflavone oxidoreductase;
isoflavone reductase;
2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
vestitone:NADP+ oxidoreductase
Reaction(IUBMB)
vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+ [RN:R06562]
Reaction(KEGG)
Substrate
vestitone [CPD:C00786];
NADP+ [CPD:C00006]
Product
2'-hydroxyformononetin [CPD:C02920];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
History
EC 1.3.1.45 created 1990
Pathway
ec00943  Isoflavonoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05281  2'-hydroxyisoflavone reductase
Genes
PSUW: WQ53_15890
LAB: LA76x_1468
LAQ: GLA29479_4369
LCP: LC55x_1203
LGU: LG3211_1114
LEZ: GLE_1089
LEM: LEN_3828
LMB: C9I47_2587
DKO: I596_1788
XBA: C7S18_04675
AVR: B565_2847
AMED: B224_3781
ACAV: VI35_14675
PSF: PSE_p0196
BAN: BA_3051
BAR: GBAA_3051
BAT: BAS2836
BAI: BAA_3101
BANT: A16_58865
BANR: A16R_31210
BANS: BAPAT_2926
BANV: DJ46_1808
BCE: BC3031
BCQ: BCQ_2858
BCX: BCA_3114
BNC: BCN_2885
BCF: bcf_14865
BTL: BALH_2726
BTT: HD73_2926
BTHI: BTK_14500
BTM: MC28_2230
BTI: BTG_04145
BTW: BF38_4219
BWW: bwei_1984
BMYO: BG05_2985
BMYC: DJ92_97
PMW: B2K_28795
JEO: JMA_07960
SAMB: SAM23877_5611(srm26)
WIN: WPG_2484
 » show all
Taxonomy
Reference
1
  Authors
Tiemann, K., Hinderer, W. and Barz, W.
  Title
Isolation of NADPH:isoflavone oxidoreductase, a new enzyme of pterocarpan biosynthesis in cell suspensions of Cicer arietinum.
  Journal
FEBS Lett 213:324-328 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.45
IUBMB Enzyme Nomenclature: 1.3.1.45
ExPASy - ENZYME nomenclature database: 1.3.1.45
BRENDA, the Enzyme Database: 1.3.1.45
CAS: 128449-69-4

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