KEGG   ENZYME: 1.3.1.68Help
Entry
EC 1.3.1.68                 Enzyme                                 

Name
1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD+ = 3-methylcatechol + NADH + CO2 [RN:R05314]
Reaction(KEGG)
Substrate
1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate [CPD:C06731];
NAD+ [CPD:C00003]
Product
3-methylcatechol [CPD:C02923];
NADH [CPD:C00004];
CO2 [CPD:C00011]
Comment
Involved in the o-xylene degradation pathway in bacteria.
History
EC 1.3.1.68 created 2000
Pathway
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:1371658]
  Authors
Higson FK, Focht DD.
  Title
Degradation of 2-methylbenzoic acid by Pseudomonas cepacia MB2.
  Journal
Appl Environ Microbiol 58:194-200 (1992)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.68
IUBMB Enzyme Nomenclature: 1.3.1.68
ExPASy - ENZYME nomenclature database: 1.3.1.68
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.68
BRENDA, the Enzyme Database: 1.3.1.68

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