KEGG   ENZYME: 1.3.1.70Help
Entry
EC 1.3.1.70                 Enzyme                                 

Name
Delta14-sterol reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ Delta14-oxidoreductase
Reaction(IUBMB)
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ [RN:R05639]
Reaction(KEGG)
R05639;
(other) R07483
Show
Substrate
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol [CPD:C05108];
NADP+ [CPD:C00006]
Product
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol [CPD:C11455];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme acts on a range of steroids with a 14(15)-double bond.
History
EC 1.3.1.70 created 2001
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00222  Delta14-sterol reductase
Genes
HSA: 7108(TM7SF2)
PTR: 451314(TM7SF2)
PPS: 100973026(TM7SF2)
GGO: 101135476(TM7SF2)
PON: 100436442(TM7SF2)
NLE: 100582089(TM7SF2)
MCC: 721985(TM7SF2)
MCF: 101865138(TM7SF2)
CSAB: 103231049(TM7SF2)
RRO: 104662828(TM7SF2)
RBB: 108543165(TM7SF2)
CJC: 100410497(TM7SF2)
SBQ: 101032782(TM7SF2)
MMU: 73166(Tm7sf2)
RNO: 293688(Tm7sf2)
CGE: 100766362(Tm7sf2)
NGI: 103724971(Tm7sf2)
HGL: 101699579(Tm7sf2)
CCAN: 109687161(Tm7sf2)
OCU: 100354153(TM7SF2)
TUP: 102479981(TM7SF2)
CFA: 476027(TM7SF2)
AML: 100469158(TM7SF2)
UMR: 103679569(TM7SF2)
ORO: 101363278(TM7SF2)
FCA: 101083545(TM7SF2)
PTG: 102955166(TM7SF2)
AJU: 106971150(TM7SF2)
BTA: 282384(TM7SF2)
BOM: 102284498(TM7SF2)
BIU: 109554379(TM7SF2)
PHD: 102343456(TM7SF2)
CHX: 100861120(TM7SF2)
OAS: 100037702(TM7SF2)
SSC: 100514510(TM7SF2)
CFR: 102518423(TM7SF2)
CDK: 105102615(TM7SF2)
BACU: 103018459(TM7SF2)
LVE: 103070851(TM7SF2)
OOR: 101285570(TM7SF2)
ECB: 100056588(TM7SF2)
EPZ: 103559145(TM7SF2)
EAI: 106833598(TM7SF2)
MYB: 102261657(TM7SF2)
MYD: 102774135(TM7SF2)
HAI: 109384274(TM7SF2)
RSS: 109450476(TM7SF2)
PALE: 102892754(TM7SF2)
LAV: 100663931(TM7SF2)
TMU: 101343201
MDO: 100030557(TM7SF2)
SHR: 100935000(TM7SF2)
FAB: 101819028
PHI: 102105655(TM7SF2)
ASN: 102376249(TM7SF2)
AMJ: 102560387(TM7SF2)
PSS: 102456010
CMY: 102941821(TM7SF2)
CPIC: 101938344(TM7SF2)
ACS: 100553093(tm7sf2)
PVT: 110069861(TM7SF2)
PBI: 103064553(TM7SF2)
GJA: 107110095(TM7SF2)
XLA: 379527(tm7sf2.L)
XTR: 100127815(tm7sf2)
NPR: 108785256(TM7SF2)
DRE: 494054(tm7sf2)
IPU: 108276901(tm7sf2)
AMEX: 103022427 103027772(tm7sf2)
TRU: 101069224(tm7sf2)
LCO: 104926328(tm7sf2)
NCC: 104954428 104954430(tm7sf2)
MZE: 101467007(tm7sf2)
OLA: 101162861(tm7sf2)
XMA: 102216750(tm7sf2)
PRET: 103476010(tm7sf2)
NFU: 107386671(tm7sf2)
CSEM: 103394887(tm7sf2)
LCF: 108894070(tm7sf2)
HCQ: 109508767(tm7sf2)
BPEC: 110165111(tm7sf2)
SASA: 106603135(tm7sf2)
ELS: 105010932(tm7sf2)
SFM: 108920219(tm7sf2) 108928614
LCM: 102367079(TM7SF2)
ATH: AT3G52940(FK)
CRB: 17886814
THJ: 104805104
CPAP: 110819749
CIT: 102613973
TCC: 18598152
VRA: 106769598
VAR: 108326294
CCAJ: 109795498
CAM: 101512523
LJA: Lj5g3v0709800.1(Lj5g3v0709800.1) Lj5g3v0709800.2(Lj5g3v0709800.2)
LANG: 109336634
FVE: 101306832
ZJU: 107432135
CSV: 101207322
CMO: 103486569
MCHA: 111014345
RCU: 8288379
JCU: 105636595
HBR: 110663703
POP: 18100073
JRE: 108984792
VVI: 100247778
SLY: 100750253(HYD2)
SPEN: 107031601
SOT: 102595277
CANN: 107843191
NSY: 104215944
NTO: 104105479
INI: 109149432
SIND: 105174121
OEU: 111412755
HAN: 110924754
LSV: 111893804
DCR: 108218804
BVG: 104898491
SOE: 110794300
NNU: 104612501
OSA: 9268311
DOSA: Os01t0354200-01(Os01g0354200) Os09t0565600-01(Os09g0565600)
OBR: 102714404
BDI: 100825049
ATS: 109760121(LOC109760121)
SBI: 8059782
ZMA: 100281352
SITA: 101752761
PDA: 103696660
MUS: 103979067
DCT: 110112609
ATR: 18441424
PPP: 112293662
APRO: F751_2894
SCE: YNL280C(ERG24)
ERC: Ecym_3597
KMX: KLMA_80276(ERG24)
NCS: NCAS_0I02580(NCAS0I02580)
NDI: NDAI_0A07170(NDAI0A07170)
TPF: TPHA_0P01120(TPHA0P01120)
TBL: TBLA_0B08330(TBLA0B08330)
TDL: TDEL_0D05430(TDEL0D05430)
KAF: KAFR_0A08190(KAFR0A08190)
CAL: CAALFM_C209400CA(ERG24)
CAUR: QG37_05162
NCR: NCU08762(erg-3)
NTE: NEUTE1DRAFT64261(NEUTE1DRAFT_64261)
MGR: MGG_13986
SSCK: SPSK_01119
MBE: MBM_02146
ANI: AN4094.2
ANG: ANI_1_446164(An18g03480) ANI_1_916014(An01g07000)
PTE: PTT_11361
ZTR: MYCGRDRAFT_109241(ERG24)
PFJ: MYCFIDRAFT_26731(ERG4)
SPO: SPBC16G5.18(erg24)
CNE: CNA01070
CNB: CNBA1040
ABP: AGABI1DRAFT114207(AGABI1DRAFT_114207)
ABV: AGABI2DRAFT191223(AGABI2DRAFT_191223)
MGL: MGL_3750
DFA: DFA_10927
MAH: MEALZ_1312(erg)
 » show all
Taxonomy
Reference
1  [PMID:32908]
  Authors
Bottema CK, Parks LW.
  Title
Delta14-sterol reductase in Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 531:301-7 (1978)
DOI:10.1016/0005-2760(78)90212-6
Reference
2  [PMID:6444198]
  Authors
Paik YK, Trzaskos JM, Shafiee A, Gaylor JL.
  Title
Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase.
  Journal
J Biol Chem 259:13413-23 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.70
IUBMB Enzyme Nomenclature: 1.3.1.70
ExPASy - ENZYME nomenclature database: 1.3.1.70
BRENDA, the Enzyme Database: 1.3.1.70
CAS: 69403-07-2

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