KEGG   ENZYME: 1.3.1.71Help
Entry
EC 1.3.1.71                 Enzyme                                 

Name
Delta24(241)-sterol reductase;
sterol Delta24(28)-methylene reductase;
sterol Delta24(28)-reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
ergosterol:NADP+ Delta24(241)-oxidoreductase
Reaction(IUBMB)
ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+ [RN:R05641]
Reaction(KEGG)
Substrate
ergosterol [CPD:C01694];
NADP+ [CPD:C00006]
Product
ergosta-5,7,22,24(241)-tetraen-3beta-ol;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a range of steroids with a 24(241)-double bond.
History
EC 1.3.1.71 created 2001, modified 2002
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K00223  Delta24(24(1))-sterol reductase
Genes
MIS: MICPUN_75586
MPP: MICPUCDRAFT_45028
SCE: YGL012W(ERG4)
AGO: AGOS_AGL087C
KLA: KLLA0_A05071g
KMX: KLMA_40436(ERG4)
LTH: KLTH0E07832g
VPO: Kpol_1061p43
ZRO: ZYRO0G10208g
CGR: CAGL0A00429g
NCS: NCAS_0A03520(NCAS0A03520)
NDI: NDAI_0A03360(NDAI0A03360)
TPF: TPHA_0F00690(TPHA0F00690)
TBL: TBLA_0C04060(TBLA0C04060)
TDL: TDEL_0F02340(TDEL0F02340)
KAF: KAFR_0A06700(KAFR0A06700) KAFR_0F03420(KAFR0F03420)
CAL: CAALFM_C300760WA(ERG4)
CAUR: QG37_02297
SLB: AWJ20_5335(ERG4)
NCR: NCU01333
NTE: NEUTE1DRAFT57468(NEUTE1DRAFT_57468)
MGR: MGG_02465
SSCK: SPSK_05103
CMT: CCM_00528
MBE: MBM_00042
ANG: ANI_1_1230064(An07g09690) ANI_1_1524124(An14g05780)
PTE: PTT_20197
ZTR: MYCGRDRAFT_77785(ERG4)
SPO: SPAC20G4.07c(sts1)
CNE: CNC04470
CNB: CNBC2700
ABP: AGABI1DRAFT112024(AGABI1DRAFT_112024)
ABV: AGABI2DRAFT193266(AGABI2DRAFT_193266)
WSE: WALSEDRAFT_61402(sts1)
MGL: MGL_2410
SMIN: v1.2.025612.t1(symbB.v1.2.025612.t1)
CBU: CBU_1206
CBD: CBUD_1293
CBG: CbuG_0804
CBC: CbuK_1070
 » show all
Taxonomy
Reference
1  [PMID:14922]
  Authors
Neal WD, Parks LW.
  Title
Sterol 24(28) methylene reductase in Saccharomyces cerevisiae.
  Journal
J Bacteriol 129:1375-8 (1977)
Reference
2  [PMID:10722850]
  Authors
Zweytick D, Hrastnik C, Kohlwein SD, Daum G.
  Title
Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae.
  Journal
FEBS Lett 470:83-7 (2000)
DOI:10.1016/S0014-5793(00)01290-4
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.71
IUBMB Enzyme Nomenclature: 1.3.1.71
ExPASy - ENZYME nomenclature database: 1.3.1.71
BRENDA, the Enzyme Database: 1.3.1.71

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