KEGG   ENZYME: 1.3.1.72Help
Entry
EC 1.3.1.72                 Enzyme                                 

Name
Delta24-sterol reductase;
lanosterol Delta24-reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
sterol:NADP+ Delta24-oxidoreductase
Reaction(IUBMB)
5alpha-cholest-7-en-3beta-ol + NADP+ = 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+ [RN:R05703]
Reaction(KEGG)
Substrate
5alpha-cholest-7-en-3beta-ol [CPD:C01189];
NADP+ [CPD:C00006]
Product
5alpha-cholesta-7,24-dien-3beta-ol [CPD:C05439];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol.
History
EC 1.3.1.72 created 2001
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09828  Delta24-sterol reductase
Genes
HSA: 1718(DHCR24)
PTR: 456879(DHCR24)
PPS: 100972820(DHCR24)
GGO: 101131027(DHCR24)
PON: 100460563(DHCR24)
NLE: 100584832(DHCR24)
MCC: 717022(DHCR24)
MCF: 102144711(DHCR24)
CSAB: 103224760(DHCR24)
RRO: 104669609(DHCR24)
RBB: 108527886(DHCR24)
CJC: 100405876(DHCR24)
SBQ: 101050483(DHCR24)
MMU: 74754(Dhcr24)
RNO: 298298(Dhcr24)
CGE: 100769920(Dhcr24)
NGI: 103734101(Dhcr24)
HGL: 101703975(Dhcr24)
CCAN: 109682111(Dhcr24)
OCU: 100339404(DHCR24)
TUP: 102493621(DHCR24)
CFA: 489573(DHCR24)
AML: 100468564(DHCR24)
UMR: 103670864(DHCR24)
ORO: 101377395(DHCR24)
FCA: 101098730(DHCR24)
PTG: 102960943(DHCR24)
AJU: 106975067(DHCR24)
BTA: 533726(DHCR24)
BOM: 102282216(DHCR24)
BIU: 109556253(DHCR24)
PHD: 102338337(DHCR24)
CHX: 102172859(DHCR24)
OAS: 101123162(DHCR24)
SSC: 100628197(DHCR24)
CFR: 102514059(DHCR24)
CDK: 105092825(DHCR24)
BACU: 102997333(DHCR24)
LVE: 103074307(DHCR24)
OOR: 101270880(DHCR24)
ECB: 100034055(DHCR24)
EPZ: 103566198(DHCR24)
EAI: 106833221(DHCR24)
MYB: 102247409(DHCR24)
MYD: 102763230(DHCR24)
HAI: 109372611(DHCR24)
PALE: 102893105(DHCR24)
LAV: 100672619(DHCR24)
TMU: 101350369
MDO: 100032491(DHCR24)
SHR: 100923525(DHCR24)
OAA: 100088141(DHCR24)
GGA: 424661(DHCR24)
MGP: 100546716(DHCR24)
CJO: 107317761(DHCR24)
APLA: 101802248(DHCR24)
ACYG: 106033080(DHCR24)
TGU: 100220338(DHCR24)
GFR: 102045301(DHCR24)
FAB: 101811656(DHCR24)
PHI: 102110388(DHCR24)
PMAJ: 107208468(DHCR24)
CCAE: 111933015(DHCR24)
CCW: 104695172(DHCR24)
FPG: 101919816(DHCR24)
FCH: 102048838(DHCR24)
CLV: 102090331(DHCR24)
EGZ: 104123952(DHCR24)
AAM: 106496004(DHCR24)
ASN: 102381399(DHCR24)
AMJ: 102561682(DHCR24)
PSS: 102450985(DHCR24)
CMY: 102929398(DHCR24)
CPIC: 101948257(DHCR24)
ACS: 100552326(dhcr24)
PVT: 110082238(DHCR24)
PBI: 103056795(DHCR24)
GJA: 107123068(DHCR24)
XLA: 444688(dhcr24.L) 447786(dhcr24.S)
XTR: 549554(dhcr24)
NPR: 108793059(DHCR24)
DRE: 494102(dhcr24)
SRX: 107716558(dhcr24)
IPU: 108257922(dhcr24)
AMEX: 103030946(dhcr24)
TRU: 101075625(dhcr24)
LCO: 104919121(dhcr24)
NCC: 104962697(dhcr24)
MZE: 101484424(dhcr24)
OLA: 101172722(dhcr24)
XMA: 102230615(dhcr24)
PRET: 103463795(dhcr24)
NFU: 107393431(dhcr24)
KMR: 108243375(dhcr24)
CSEM: 103376648(dhcr24)
LCF: 108879153(dhcr24)
SDU: 111226415(dhcr24)
HCQ: 109532187(dhcr24)
BPEC: 110154784(dhcr24)
MALB: 109961993(dhcr24)
SASA: 106560235 106584213(dhcr24)
OTW: 112248909(dhcr24)
ELS: 105011791(dhcr24)
SFM: 108935136(dhcr24)
LCM: 102351351(DHCR24)
CMK: 103182734(dhcr24)
SPU: 587262(dhcr24)
SKO: 100369348(DHCR24)
AAG: 5575872
NVI: 100123384
DPA: 109533804
DNX: 107163118
ZNE: 110827611
CEL: CELE_F52H2.6(F52H2.6)
CBR: CBG02085
CRG: 105347433
MYI: 110452558
LAK: 106176554
EPA: 110235299
ATH: AT3G19820(DWF1)
CRB: 17891784
CIT: 102618829
TCC: 18610069
EGR: 104421584
VRA: 106756367
VAR: 108340606
CCAJ: 109798769
CAM: 101507942
LJA: Lj3g3v3511360.1(Lj3g3v3511360.1)
ADU: 107477170
AIP: 107628731
FVE: 101295708
PPER: 18793320
PMUM: 103321055
PAVI: 110754644
PXB: 103943196
JCU: 105634671
HBR: 110649201
JRE: 108979238
VVI: 100258158
SLY: 101244831 543937(SlSSR1)
SOT: 102584296(StSSR2) 102604696(StSSR1)
INI: 109164986
SIND: 105175842
OEU: 111374973
BVG: 104902610
SOE: 110787922
NNU: 104611785
DOSA: Os10t0397400-01(Os10g0397400)
OBR: 102708833
ATS: 109760115(LOC109760115)
ZMA: 542549(DWF1)
ATR: 18437615
CMT: CCM_05983
SMIN: v1.2.014846.t1(symbB.v1.2.014846.t1) v1.2.014847.t1(symbB.v1.2.014847.t1)
SPAR: SPRG_04988
MCA: MCA1404
 » show all
Taxonomy
Reference
1  [PMID:9291139]
  Authors
Bae SH, Paik YK.
  Title
Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase.
  Journal
Biochem J 326 ( Pt 2):609-16 (1997)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.72
IUBMB Enzyme Nomenclature: 1.3.1.72
ExPASy - ENZYME nomenclature database: 1.3.1.72
BRENDA, the Enzyme Database: 1.3.1.72
CAS: 9033-57-2

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