KEGG   ENZYME: 1.3.1.74Help
Entry
EC 1.3.1.74                 Enzyme                                 

Name
2-alkenal reductase [NAD(P)+];
NAD(P)H-dependent alkenal/one oxidoreductase;
NADPH:2-alkenal alpha,beta-hydrogenase;
2-alkenal reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
n-alkanal:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
a n-alkanal + NAD(P)+ = an alk-2-enal + NAD(P)H + H+ [RN:R07349 R07350]
Reaction(KEGG)
Substrate
n-alkanal [CPD:C15596];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
alk-2-enal [CPD:C15597];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Highly specific for 4-hydroxynon-2-enal and non-2-enal. Alk-2-enals of shorter chain have lower affinities. Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones [cf. EC 1.3.1.102, 2-alkenal reductase (NADP+)].
History
EC 1.3.1.74 created 2003, modified 2014
Orthology
K08070  2-alkenal reductase
K13948  prostaglandin reductase 1
Genes
HSA: 22949(PTGR1)
PTR: 740274(PTGR1)
PPS: 100979208(PTGR1)
GGO: 101147031(PTGR1)
PON: 100461388(PTGR1)
NLE: 100591499(PTGR1)
MCC: 708725(PTGR1) 711690
MCF: 102121945(PTGR1) 102123447
CSAB: 103219015 103219016
RRO: 104660871(PTGR1) 104660872
RBB: 108538016
CJC: 100415416(PTGR1)
SBQ: 101029862(PTGR1)
MMU: 67103(Ptgr1)
RNO: 192227(Ptgr1)
CGE: 100756865(Ptgr1)
NGI: 103732531(Ptgr1)
HGL: 101699930(Ptgr1)
OCU: 100009440(PTGR1) 100352119
TUP: 102470772(PTGR1)
CFA: 474802(PTGR1)
AML: 100477631(PTGR1)
UMR: 103678576(PTGR1)
ORO: 101370295(PTGR1)
FCA: 101093468(PTGR1)
PTG: 102969809(PTGR1)
AJU: 106971775(PTGR1)
BTA: 513177(PTGR1)
BOM: 102271298(PTGR1)
BIU: 109563341(PTGR1)
PHD: 102315207(PTGR1)
CHX: 102190414(PTGR1)
OAS: 101112113(PTGR1)
SSC: 397678(PTGR1)
CFR: 102522787(PTGR1)
CDK: 105096405(PTGR1)
BACU: 103020505(PTGR1)
LVE: 103090270(PTGR1)
OOR: 101269785(PTGR1)
ECB: 100058059(PTGR1)
EPZ: 103546638(PTGR1)
EAI: 106826909(PTGR1)
MYB: 102257971(PTGR1)
MYD: 102763537(PTGR1)
HAI: 109379309(PTGR1)
RSS: 109456976(PTGR1)
PALE: 102892647(PTGR1)
LAV: 100666912(PTGR1)
TMU: 101343314
MDO: 100017288(PTGR1)
SHR: 100920365(PTGR1)
OAA: 100092763(PTGR1)
GGA: 427337(PTGR1)
MGP: 100540778(PTGR1)
CJO: 107306568(PTGR1)
APLA: 101802303(PTGR1)
ACYG: 106043043(PTGR1)
TGU: 100229401(PTGR1)
GFR: 102038916(PTGR1)
FAB: 101819125(PTGR1)
PHI: 102112137(PTGR1)
PMAJ: 107216111(PTGR1)
CCW: 104690480(PTGR1)
FPG: 101921174(PTGR1)
FCH: 102048030(PTGR1)
CLV: 102084507(PTGR1)
EGZ: 104123050(PTGR1)
AAM: 106499587(PTGR1)
ASN: 102383805(PTGR1)
AMJ: 102573310(PTGR1)
PSS: 102459466(PTGR1)
CMY: 102934937
CPIC: 101935091(PTGR1)
ACS: 100559950(ptgr1)
PVT: 110077730(PTGR1)
PBI: 103050299(PTGR1)
GJA: 107109016(PTGR1)
XLA: 108706923 108713640 446864(ptgr1.2.L) 495998(ptgr1.1.S)
XTR: 100135160(ptgr1.2) 493462(ltb4dh) 496616(ptgr1.1)
DRE: 494108(ptgr1)
TRU: 101078055(ptgr1)
LCO: 104932914(ptgr1)
NCC: 104945005(ptgr1)
XMA: 102216857 102230401(ptgr1)
NFU: 107377268(ptgr1)
HCQ: 109508445(ptgr1)
SFM: 108925887(ptgr1)
LCM: 102359028(PTGR1)
CMK: 103187214(ptgr1)
AAG: 5576311
AME: 411378
BIM: 100743002
BTER: 110119173
PBAR: 105431181
CFO: 105248598
PGC: 109859160
PMAC: 106717792
PXY: 105389791
API: 100162222
DNX: 107173710
TSP: Tsp_01072
HMG: 100199266
THJ: 104805677
PXB: 103942943
SSE: Ssed_0744
LCH: Lcho_2947
RPT: Rpal_3736
MEX: Mext_4798
MCH: Mchl_5265
MPO: Mpop_5341
MET: M446_3040
ACR: Acry_1324
CSC: Csac_2307
STI: Sthe_0612
 » show all
Taxonomy
Reference
1  [PMID:12514241]
  Authors
Mano J, Torii Y, Hayashi S, Takimoto K, Matsui K, Nakamura K, Inze D, Babiychuk E, Kushnir S, Asada K.
  Title
The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes.
  Journal
Plant Cell Physiol 43:1445-55 (2002)
  Sequence
[ath:AT5G16970]
Reference
2  [PMID:11524419]
  Authors
Dick RA, Kwak MK, Sutter TR, Kensler TW.
  Title
Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase.
  Journal
J Biol Chem 276:40803-10 (2001)
DOI:10.1074/jbc.M105487200
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.74
IUBMB Enzyme Nomenclature: 1.3.1.74
ExPASy - ENZYME nomenclature database: 1.3.1.74
BRENDA, the Enzyme Database: 1.3.1.74
CAS: 52227-95-9

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