KEGG   ENZYME: 1.3.1.77Help
Entry
EC 1.3.1.77                 Enzyme                                 

Name
anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming];
ANR (gene name) (ambiguous);
flavan-3-ol:NAD(P)+ oxidoreductase;
anthocyanidin reductase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2R,3R)-flavan-3-ol:NAD(P)+ 3,4-oxidoreductase
Reaction(IUBMB)
a (2R,3R)-flavan-3-ol + 2 NAD(P)+ = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H + H+ [RN:R07351 R07352]
Reaction(KEGG)
Substrate
(2R,3R)-flavan-3-ol [CPD:C15598];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
anthocyanidin with a 3-hydroxy group [CPD:C21381];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming].
History
EC 1.3.1.77 created 2004, modified 2016
Pathway
ec00941  Flavonoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K08695  anthocyanidin reductase
Genes
ATH: AT1G61720(BAN)
ALY: ARALYDRAFT_893331
CRB: 17894009
CSAT: 104703765 104714500 104752826
EUS: EUTSA_v10023567mg
BRP: 103831042 103838541(A.BANb)
BNA: 106352233 106374812 106374840 106395425
BOE: 106302532 106323258 106341298
THJ: 104809521
CPAP: 110812199
CIT: 102618954
TCC: 18597033(ANR)
GRA: 105768219
DZI: 111280787
GMX: 100805127(ANR1) 100817081(ANR2)
CAM: 101494604
LJA: Lj4g3v0423090.1(Lj4g3v0423090.1)
ADU: 107480609
AIP: 107626250
LANG: 109330732
FVE: 101297977
PPER: 18778549
PMUM: 103324591
PAVI: 110768767
MDM: 103434638(ANR2a)
ZJU: 107421422
RCU: 8267420
JCU: 105649408
HBR: 110658083
SLY: 101263493
SPEN: 107012467
SOT: 102584577
NSY: 104233566
NTO: 104120432
BVG: 104883056
DOSA: Os04t0630100-01(Os04g0630100) Os04t0630300-01(Os04g0630300) Os04t0630400-01(Os04g0630400) Os04t0630600-00(Os04g0630600) Os04t0630800-01(Os04g0630800) Os04t0630900-01(Os04g0630900) Os04t0631000-00(Os04g0631000)
ATS: 109733882(LOC109733882) 109736125(LOC109736125) 109736130 109736133 109738472(LOC109738472) 109750081(LOC109750081) 109766837(LOC109766837) 109778519(LOC109778519)
PDA: 103698208
EGU: 105035639
MUS: 103994101
AOF: 109821630
ATR: 18427888
 » show all
Taxonomy
Reference
1  [PMID:12532018]
  Authors
Xie DY, Sharma SB, Paiva NL, Ferreira D, Dixon RA.
  Title
Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis.
  Journal
Science 299:396-9 (2003)
DOI:10.1126/science.1078540
  Sequence
Reference
2  [PMID:14725861]
  Authors
Xie DY, Sharma SB, Dixon RA.
  Title
Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana.
  Journal
Arch Biochem Biophys 422:91-102 (2004)
DOI:10.1016/j.abb.2003.12.011
  Sequence
[ath:AT1G61720]
Reference
3  [PMID:23288883]
  Authors
Pang Y, Abeysinghe IS, He J, He X, Huhman D, Mewan KM, Sumner LW, Yun J, Dixon RA
  Title
Functional characterization of proanthocyanidin pathway enzymes from tea and their application for metabolic engineering.
  Journal
Plant Physiol 161:1103-16 (2013)
DOI:10.1104/pp.112.212050
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.77
IUBMB Enzyme Nomenclature: 1.3.1.77
ExPASy - ENZYME nomenclature database: 1.3.1.77
BRENDA, the Enzyme Database: 1.3.1.77
CAS: 93389-48-1

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