KEGG   ENZYME: 1.3.1.78Help
Entry
EC 1.3.1.78                 Enzyme                                 

Name
arogenate dehydrogenase (NADP+);
arogenic dehydrogenase (ambiguous);
pretyrosine dehydrogenase (ambiguous);
TyrAAT1;
TyrAAT2;
TyrAa
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-arogenate:NADP+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 [RN:R00733]
Reaction(KEGG)
Substrate
L-arogenate [CPD:C00826];
NADP+ [CPD:C00006]
Product
L-tyrosine [CPD:C00082];
NADPH [CPD:C00005];
CO2 [CPD:C00011]
Comment
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].
History
EC 1.3.1.78 created 2005
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15226  arogenate dehydrogenase (NADP+)
K15227  arogenate dehydrogenase (NADP+), plant
Genes
ATH: AT1G15710 AT5G34930
ALY: ARALYDRAFT_493579 ARALYDRAFT_888961
CRB: 111832551 17878621
CSAT: 104719228 104728176 104732493 104732495 104740255 104755882 104774340 104774398
EUS: EUTSA_v10008067mg EUTSA_v10020287mg
BRP: 103842888 103858107
BNA: 106367072 106414620 106438203 111200313
BOE: 106311520 106335007
THJ: 104808204 104812465 104815295 104824345 104826560
CPAP: 110821063 110821065 110826128
GMX: 100787362(PDH1) 100801552(ADH1) 100803165 100803931(TYRA-A) 100810896(PDH2)
LJA: Lj4g3v1936580.1(Lj4g3v1936580.1) Lj6g3v0452120.1(Lj6g3v0452120.1)
CSV: 101214147
CMO: 103496957
MCHA: 111013055
DCR: 108215982
DOSA: Os06t0542200-01(Os06g0542200) Os06t0708832-00(Os06g0708832) Os06t0709000-01(Os06g0709000)
ATS: 109757600(LOC109757600) 109758435(LOC109758435) 109758438(LOC109758438)
CRE: CHLREDRAFT_191605(AGD1)
VCN: VOLCADRAFT_78949(agd1)
MNG: MNEG_1533
OLU: OSTLU_119548(ardH)
APRO: F751_6083
FCY: FRACYDRAFT_191710(tyrC)
SYN: slr2081(tyrA)
SYZ: MYO_114060(tyrA)
SYY: SYNGTS_1394(tyrA)
SYT: SYNGTI_1394(tyrA)
SYS: SYNPCCN_1393(tyrA)
SYQ: SYNPCCP_1393(tyrA)
SYJ: D082_12010(tyrA)
SYW: SYNW2058
SYC: syc0868_c(tyrA)
SYG: sync_0447(tyrA)
SYR: SynRCC307_2107(tyrA)
SYX: SynWH7803_0443(tyrA)
SYP: SYNPCC7002_A0677(tyrA)
CYA: CYA_2300(tyrA)
CYB: CYB_0624(tyrA)
SYNR: KR49_10995
SYND: KR52_00505
SYNW: SynWH8103_02365(tyrA)
TEL: tll2435(tyrA)
THN: NK55_00825(tyrA)
LET: O77CONTIG1_00666(tyrA)
LBO: LBWT_6830
HHG: XM38_009440(tyrA)
PMA: Pro_1719(tyrA)
PMM: PMM1565
PMT: PMT_1724
PMB: A9601_17721(tyrA)
PMC: P9515_17521(tyrA)
PMF: P9303_22941(tyrA)
PMG: P9301_17561(tyrA)
PMH: P9215_18371(tyrA)
PMJ: P9211_16841(tyrA)
PME: NATL1_20101(tyrA)
PRC: EW14_1923
PRM: EW15_2083
AMR: AM1_2942(tyrA)
MAR: MAE_55280
MPK: VL20_422
CYL: AA637_05210(tyrAa)
CYT: cce_4463(tyrA)
TER: Tery_2701
ARP: NIES39_N00690(tyrA)
GVI: gvip038(tyrA)
GLJ: GKIL_4393(tyrAa)
ANA: all1141
AVA: Ava_4397
NAZ: Aazo_3900
CALH: IJ00_23290
CTHE: Chro_0609
CEO: ETSB_0416(tyrA)
 » show all
Taxonomy
Reference
1  [PMID:24272471]
  Authors
Gaines CG, Byng GS, Whitaker RJ, Jensen RA
  Title
L-tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes.
  Journal
Planta 156:233-40 (1982)
DOI:10.1007/BF00393730
Reference
2  [PMID:12354106]
  Authors
Rippert P, Matringe M
  Title
Purification and kinetic analysis of the two recombinant arogenate dehydrogenase  isoforms of Arabidopsis thaliana.
  Journal
Eur J Biochem 269:4753-61 (2002)
DOI:10.1046/j.1432-1033.2002.03172.x
  Sequence
Reference
3  [PMID:15171683]
  Authors
Bonner CA, Jensen RA, Gander JE, Keyhani NO.
  Title
A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis.
  Journal
Biochem J 382:279-91 (2004)
DOI:10.1042/BJ20031809
  Sequence
[syn:slr2081]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.78
IUBMB Enzyme Nomenclature: 1.3.1.78
ExPASy - ENZYME nomenclature database: 1.3.1.78
BRENDA, the Enzyme Database: 1.3.1.78
CAS: 64295-75-6

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