KEGG   ENZYME: 1.3.1.86Help
Entry
EC 1.3.1.86                 Enzyme                                 

Name
crotonyl-CoA reductase;
butyryl-CoA dehydrogenase;
butyryl dehydrogenase;
unsaturated acyl-CoA reductase;
ethylene reductase;
enoyl-coenzyme A reductase;
unsaturated acyl coenzyme A reductase;
butyryl coenzyme A dehydrogenase;
short-chain acyl CoA dehydrogenase;
short-chain acyl-coenzyme A dehydrogenase;
3-hydroxyacyl CoA reductase;
butanoyl-CoA:(acceptor) 2,3-oxidoreductase;
CCR
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
butanoyl-CoA:NADP+ 2,3-oxidoreductase
Reaction(IUBMB)
butanoyl-CoA + NADP+ = (E)-but-2-enoyl-CoA + NADPH + H+ [RN:R09738]
Reaction(KEGG)
Substrate
butanoyl-CoA [CPD:C00136];
NADP+ [CPD:C00006]
Product
(E)-but-2-enoyl-CoA [CPD:C00877];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reaction in the reverse direction. This enzyme from Streptomyces collinus is specific for (E)-but-2-enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis.
History
EC 1.3.1.86 created 2011
Pathway
ec00650  Butanoate metabolism
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K17829  crotonyl-CoA reductase
Genes
ANT: Arnit_2215
DDS: Ddes_1332
DEF: CNY67_08750(ccrA)
DOA: AXF15_01755
RSU: NHU_00907(ttmP)
NNO: NONO_c15260
NTP: CRH09_08285(ccrA)
RFA: A3L23_04984(ccrA2)
TPR: Tpau_3474
SCO: SCO6473(SC9C7.09c)
SALB: XNR_0456
SMA: SAVERM_1911(ccrA2) SAVERM_2890(ccrA1)
SGR: SGR_1170
SGB: WQO_29560
SCT: SCAT_0122 SCAT_3263(ccr) SCAT_4859(ccr) SCAT_5748(ccrA)
SFA: Sfla_0905
SHY: SHJG_7434
SVE: SVEN_6307
STRP: F750_5949
SFI: SFUL_6327
SCI: B446_01590(kirN) B446_29770 B446_33700(kirN)
SLV: SLIV_06060(ccrA2)
SGU: SGLAU_27255(ccrA2)
SLD: T261_1717
SAMB: SAM23877_5633(srm4) SAM23877_6067(ccr)
SPRI: SPRI_1330
SRW: TUE45_01107(ccr_1) TUE45_07075(ccr_2)
SLE: sle_13020(sle_13020) sle_22910(sle_22910)
SRN: A4G23_04917(ccr)
SNR: SNOUR_10725(ccrA2) SNOUR_41350(ccr)
STRD: NI25_06035
SALF: SMD44_00393(ccrA) SMD44_07018(ccrA)
SALJ: SMD11_0917(ccrA) SMD11_1338(ccrA)
SLX: SLAV_08020(ccrA1)
KSK: KSE_56510(ccr1) KSE_65530(ccr3) KSE_70410(ccr2)
STRI: C7M71_024015(ccrA)
NCA: Noca_1795
NDK: I601_3892(ccr_1)
KFL: Kfla_4989
PSIM: KR76_10630
AEZ: C3E78_12365(ccrA)
NAL: B005_2057
TCU: Tcur_4755
SRO: Sros_8814
FAL: FRAAL2539(ccrA) FRAAL5913
GOB: Gobs_4114
AMD: AMED_1574(qor)
AMN: RAM_07995
AMM: AMES_1564(qor)
AMZ: B737_1565(qor)
AOI: AORI_6359(ccr)
AJA: AJAP_07605(ccr)
AMQ: AMETH_5552(qor)
AMYC: CU254_06330(ccrA)
PDX: Psed_1713
PSEA: WY02_10715
PSEE: FRP1_03485
PSEH: XF36_19290
AMI: Amir_3664
SESP: BN6_73120
KAL: KALB_7555
AHG: AHOG_15470(ccr)
SAQ: Sare_3994
MIL: ML5_3210
ACTN: L083_2886
CAI: Caci_1252
SNA: Snas_4138
AFO: Afer_0105
 » show all
Taxonomy
Reference
1  [PMID:8521864]
  Authors
Wallace KK, Bao ZY, Dai H, Digate R, Schuler G, Speedie MK, Reynolds KA
  Title
Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli.
  Journal
Eur J Biochem 233:954-62 (1995)
DOI:10.1111/j.1432-1033.1995.954_3.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.86
IUBMB Enzyme Nomenclature: 1.3.1.86
ExPASy - ENZYME nomenclature database: 1.3.1.86
BRENDA, the Enzyme Database: 1.3.1.86

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