KEGG   ENZYME: 1.3.1.88Help
Entry
EC 1.3.1.88                 Enzyme                                 

Name
tRNA-dihydrouridine16/17 synthase [NAD(P)+];
Dus1p;
tRNA-dihydrouridine synthase 1
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
tRNA-5,6-dihydrouracil16/17:NAD(P)+ oxidoreductase
Reaction(IUBMB)
(1) 5,6-dihydrouracil16 in tRNA + NAD(P)+ = uracil16 in tRNA + NAD(P)H + H+;
(2) 5,6-dihydrouracil17 in tRNA + NAD(P)+ = uracil17 in tRNA + NAD(P)H + H+
Substrate
5,6-dihydrouracil16 in tRNA;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
5,6-dihydrouracil17 in tRNA
Product
uracil16 in tRNA;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
uracil17 in tRNA
Comment
A flavoprotein. The enzyme specifically modifies uracil16 and uracil17 in tRNA.
History
EC 1.3.1.88 created 2011
Orthology
K05542  tRNA-dihydrouridine synthase 1
Genes
HSA: 64118(DUS1L)
PTR: 104001056(DUS1L) 745178
PPS: 100986536(DUS1L)
GGO: 101147690(DUS1L)
PON: 100452532(DUS1L)
NLE: 100597375(DUS1L)
MCC: 715662(DUS1L)
MCF: 102119033(DUS1L)
CSAB: 103243753(DUS1L)
RRO: 104654983(DUS1L)
RBB: 108534088(DUS1L)
CJC: 100394600(DUS1L)
SBQ: 101030958(DUS1L)
MMU: 68730(Dus1l)
RNO: 246185(Dus1l)
CGE: 100770971(Dus1l)
NGI: 103730057(Dus1l)
HGL: 101697689(Dus1l)
CCAN: 109702631(Dus1l)
TUP: 102482761(DUS1L)
CFA: 475927(DUS1L)
AML: 100478032(DUS1L)
UMR: 103665826(DUS1L)
ORO: 101372586(DUS1L)
FCA: 101081268(DUS1L)
PTG: 102956651(DUS1L)
AJU: 106986312(DUS1L)
BTA: 617998(DUS1L)
BOM: 102278555(DUS1L)
BIU: 109573331(DUS1L)
PHD: 102336533(DUS1L)
CHX: 102188705(DUS1L)
OAS: 101111894(DUS1L)
SSC: 100623965(DUS1L)
CFR: 102506500(DUS1L)
CDK: 105102218(DUS1L)
BACU: 103017194(DUS1L)
LVE: 103078016(DUS1L)
OOR: 101279317(DUS1L)
ECB: 100057354(DUS1L)
EPZ: 103551110(DUS1L)
EAI: 106846130(DUS1L)
MYB: 102250706(DUS1L)
MYD: 102771375(DUS1L)
HAI: 109393002(DUS1L)
RSS: 109449381(DUS1L)
PALE: 102879160(DUS1L)
LAV: 100663357(DUS1L)
TMU: 101359801
MDO: 100029826(DUS1L)
SHR: 100918126(DUS1L)
OAA: 100681132
GGA: 417381(DUS1L)
MGP: 100544355 104913776(DUS1L)
CJO: 107322078(DUS1L)
APLA: 101795436(DUS1L)
ACYG: 106046766(DUS1L)
TGU: 100229753(DUS1L)
GFR: 102045491(DUS1L)
FAB: 101821422(DUS1L)
PHI: 102102583(DUS1L)
PMAJ: 107212316(DUS1L)
CCW: 104698183(DUS1L)
FPG: 101914655(DUS1L)
FCH: 102054845(DUS1L)
CLV: 102095093(DUS1L)
EGZ: 104131265(DUS1L)
AAM: 106487143(DUS1L)
ASN: 102384910(DUS1L)
AMJ: 102564218(DUS1L)
PSS: 102458336(DUS1L)
CMY: 102933429(DUS1L)
CPIC: 101941612(DUS1L)
ACS: 100563326(dus1l)
PVT: 110090796(DUS1L)
PBI: 103062801(DUS1L)
GJA: 107118136(DUS1L)
XLA: 432319(dus1l.S) 446385(dus1l.L)
XTR: 100380012(dus1l)
NPR: 108791315(DUS1L)
DRE: 322715(dus1l)
IPU: 108259362(dus1l)
AMEX: 103021876(dus1l)
TRU: 101064396(dus1l)
LCO: 104935248(dus1l)
NCC: 104948689(dus1l)
MZE: 101480750(dus1l)
OLA: 101173228(dus1l)
XMA: 102225143(dus1l)
PRET: 103468186(dus1l)
NFU: 107391601(dus1l)
CSEM: 103393617(dus1l)
HCQ: 109532538(dus1l)
BPEC: 110162490(dus1l)
SASA: 106593101 106606201(dus1l)
ELS: 105031327(dus1l)
SFM: 108940098(dus1l)
LCM: 102362185(DUS1L)
CMK: 103175471(dus1l)
APLC: 110980325
SKO: 102800902
DME: Dmel_CG3645(CG3645)
DSI: Dsimw501_GD22975(Dsim_GD22975)
MDE: 101893318
AAG: 5573943
AME: 409102
BIM: 100750100
BTER: 100647850
SOC: 105204722
AEC: 105154368
ACEP: 105622979
HST: 105183065
NVI: 100123506
TCA: 655886
NVL: 108560324
BMOR: 101735813
PMAC: 106720129
PRAP: 110992748
PXY: 105384219
API: 100163450
DNX: 107164840
ZNE: 110827426
FCD: 110850991
TUT: 107362503
CEL: CELE_F36A2.2(F36A2.2)
CBR: CBG12371
BMY: Bm1_48360
TSP: Tsp_11571
MYI: 110448614
OBI: 106882767
LAK: 106172381
SHX: MS3_09782
EGL: EGR_03341
EPA: 110240032
AQU: 100633889
ATH: AT5G67220
CRB: 17877234
CPAP: 110814363
CIT: 102626482
TCC: 18611184
GRA: 105787639
DZI: 111291790
EGR: 104416869
VRA: 106768695
VAR: 108319427
CCAJ: 109788174
CAM: 101493683
LJA: Lj4g3v0818970.1(Lj4g3v0818970.1)
ADU: 107479589
AIP: 107627100
LANG: 109350122
FVE: 101312491
PPER: 18772516
PMUM: 103337538
PAVI: 110746396
MDM: 103401401
PXB: 103961587
CSV: 101209488
CMO: 103501114
MCHA: 111017278
RCU: 8272978
JCU: 105639757
HBR: 110657425
POP: 7483096
JRE: 109009106
VVI: 100249291
SIND: 105176214
OEU: 111400999
DCR: 108214830
BVG: 104894874
SOE: 110779166
NNU: 104601710
OSA: 4342049
DOSA: Os06t0712900-01(Os06g0712900)
OBR: 102718562
BDI: 100834475
ATS: 109731509(LOC109731509)
SBI: 8064984
ZMA: 100274382
SITA: 101781482
PDA: 103722958
EGU: 105033329
MUS: 103998842
DCT: 110113878
AOF: 109832172
ATR: 18432595
MNG: MNEG_3305
APRO: F751_3616
SCE: YML080W(DUS1)
ERC: Ecym_1130
KMX: KLMA_40516(DUS1)
NCS: NCAS_0A06240(NCAS0A06240)
NDI: NDAI_0D03230(NDAI0D03230)
TPF: TPHA_0K00550(TPHA0K00550)
TBL: TBLA_0B06180(TBLA0B06180)
TDL: TDEL_0D00680(TDEL0D00680)
KAF: KAFR_0B06800(KAFR0B06800)
CAL: CAALFM_C209500WA(CaO19.1404)
CAUR: QG37_07692
SLB: AWJ20_4758(DUS1)
NCR: NCU00065
NTE: NEUTE1DRAFT62941(NEUTE1DRAFT_62941)
MGR: MGG_08825
MAW: MAC_00361
MAJ: MAA_06010
CMT: CCM_01819
MBE: MBM_00979
ANI: AN0956.2
ANG: ANI_1_1438014(An01g10700)
CIM: CIMG_13670(CIMG03043)
ABE: ARB_02173
TVE: TRV_00424
PTE: PTT_09419
CNE: CNA04140
CNB: CNBA3960
ABP: AGABI1DRAFT67813(AGABI1DRAFT_67813) AGABI1DRAFT77367(AGABI1DRAFT_77367)
ABV: AGABI2DRAFT181833(AGABI2DRAFT_181833) AGABI2DRAFT208170(AGABI2DRAFT_208170)
DDI: DDB_G0278803(dus1l)
DFA: DFA_01528(dus1l)
EHI: EHI_164780(34.t00020)
SMIN: v1.2.001418.t1(symbB.v1.2.001418.t1) v1.2.008718.t1(symbB.v1.2.008718.t1) v1.2.036296.t1(symbB.v1.2.036296.t1) v1.2.036296.t2(symbB.v1.2.036296.t2) v1.2.040085.t1(symbB.v1.2.040085.t1)
TCR: 506107.20
 » show all
Taxonomy
Reference
1  [PMID:14970222]
  Authors
Xing F, Hiley SL, Hughes TR, Phizicky EM
  Title
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs.
  Journal
J Biol Chem 279:17850-60 (2004)
DOI:10.1074/jbc.M401221200
  Sequence
[sce:YML080W]
Reference
2  [PMID:12003496]
  Authors
Xing F, Martzen MR, Phizicky EM
  Title
A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA.
  Journal
RNA 8:370-81 (2002)
  Sequence
[sce:YML080W]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.88
IUBMB Enzyme Nomenclature: 1.3.1.88
ExPASy - ENZYME nomenclature database: 1.3.1.88
BRENDA, the Enzyme Database: 1.3.1.88

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