KEGG   ENZYME: 1.3.1.93Help
Entry
EC 1.3.1.93                 Enzyme                                 

Name
very-long-chain enoyl-CoA reductase;
TSC13 (gene name);
CER10 (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
very-long-chain acyl-CoA:NADP+ oxidoreductase
Reaction(IUBMB)
a very-long-chain acyl-CoA + NADP+ = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+ [RN:R10828]
Reaction(KEGG)
R10828;
(other) R07761 R09449
Show
Substrate
very-long-chain acyl-CoA [CPD:C20876];
NADP+ [CPD:C00006]
Product
very-long-chain trans-2,3-dehydroacyl-CoA [CPD:C20879];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase.
History
EC 1.3.1.93 created 2012
Pathway
ec00062  Fatty acid elongation
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K10258  very-long-chain enoyl-CoA reductase
Genes
HSA: 9524(TECR)
PTR: 455786(TECR)
PPS: 100971383(TECR)
GGO: 101140023(TECR) 109025468
PON: 100440904(TECR)
NLE: 100581652(TECR)
MCC: 718928(TECR)
MCF: 101926702(TECR)
CSAB: 103234044(TECR)
RRO: 104661039(TECR)
RBB: 108514773(TECR)
CJC: 100402213(TECR)
SBQ: 101033875(TECR)
MMU: 106529(Tecr)
RNO: 191576(Tecr)
CGE: 100761652(Tecr)
NGI: 103751841(Tecr)
HGL: 101716060(Tecr)
CCAN: 109686636(Tecr)
OCU: 103346023(TECR)
TUP: 102480210(TECR)
CFA: 476687(TECR)
AML: 100467030(TECR)
UMR: 103682180(TECR)
ORO: 101386071(TECR)
FCA: 101091601(TECR)
PTG: 102948536 102959844(TECR)
AJU: 106986213(TECR)
BTA: 614105(TECR)
BOM: 102285957(TECR)
BIU: 109561491(TECR)
PHD: 102340071(TECR)
CHX: 102187120(TECR)
OAS: 101117331(TECR)
SSC: 100515709(TECR)
CFR: 102519742(TECR)
CDK: 105105973(TECR)
BACU: 102997227(TECR)
LVE: 103070891(TECR)
OOR: 101269817(TECR)
ECB: 100065024(TECR)
EPZ: 103565661(TECR)
EAI: 106844303(TECR)
MYB: 102260613(TECR)
MYD: 102751823(TECR)
HAI: 109394266(TECR)
RSS: 109442713 109454938(TECR)
PALE: 102887858(TECR)
LAV: 100674918(TECR)
TMU: 101348735
MDO: 100026440(TECR) 100032861
SHR: 100914010(TECR)
OAA: 100080249 100081999(TECR)
GGA: 424491(TECR)
MGP: 100545685(TECR)
CJO: 107307749(TECR) 107317393
APLA: 101799511(TECR)
ACYG: 106039444(TECR)
TGU: 100230168(TECR)
GFR: 102032504(TECR)
FAB: 101810425(TECR) 101812411
PHI: 102099600(TECR) 106628096
CCW: 104695353(TECR)
CLV: 110363827(TECR)
EGZ: 104134018(TECR)
AAM: 106484788 106499774(TECR)
ASN: 102370679(TECR) 102383204
AMJ: 102559187(TECR) 102575131
PSS: 102457301(TECR) 102459125
CMY: 102929357(TECR) 102931932
CPIC: 101937001(TECR) 101945886
ACS: 100560578 100566730(tecr)
PVT: 110070802(TECR) 110076484
PBI: 103058993 103065171(TECR)
GJA: 107112228 107117643(TECR)
XLA: 108713542 380153(gpsn2) 444160(tecr.L)
XTR: 493561(tecr) 780081
NPR: 108789250 108797751(TECR)
DRE: 326954(tecrb) 566085(tecra) 798606(tecrl2a)
HCQ: 109521419 109527436(tecr)
CMK: 103174648 103191170(tecr)
CIN: 100183960
SPU: 576023
DME: Dmel_CG10849(Sc2)
DSI: Dsimw501_GD13786(Dsim_GD13786)
MDE: 101887858
AAG: 5570994
AME: 725146
BIM: 100747299
BTER: 100644169
SOC: 105193039
AEC: 105153980
ACEP: 105618040
PBAR: 105433004
HST: 105181228
CFO: 105259215
LHU: 105673344
PGC: 109859407
TCA: 659815
DPA: 109537890
NVL: 108567063
BMOR: 101742899
PMAC: 106718707
PRAP: 110995799
PXY: 105385206
API: 100160468
ZNE: 110835131
FCD: 110859769
TUT: 107369209
CEL: CELE_C15F1.6(art-1)
CBR: CBG11196(Cbr-art-1)
BMY: Bm1_42555
TSP: Tsp_07269
CRG: 105326706
MYI: 110461543
OBI: 106878132
LAK: 106164649
SHX: MS3_09546
EGL: EGR_03533
AQU: 100640363
ATH: AT3G55360(CER10)
ALY: ARALYDRAFT_906954(ATTSC13)
CRB: 17884738
BRP: 103841442
TCC: 18586099
EGR: 104454293
CAM: 101496420 101508101(sr5a)
LJA: Lj0g3v0067399.1(Lj0g3v0067399.1) Lj0g3v0067409.1(Lj0g3v0067409.1)
PPER: 18784679
PMUM: 103332647
PAVI: 110756623
ZJU: 107413483
CSV: 101213758
CMO: 103498153
JCU: 105647736
VVI: 100266766
DCR: 108210643
SOE: 110794839
NNU: 104594555
OSA: 4324516
DOSA: Os01t0150000-01(Os01g0150000)
ATS: 109777279(LOC109777279)
SBI: 8060800
ZMA: 100191179(AY106269) 103633692
EGU: 105052214
MNG: MNEG_5026
APRO: F751_1654
SCE: YDL015C(TSC13)
ERC: Ecym_5259
KMX: KLMA_10196(TSC13)
NCS: NCAS_0I01880(NCAS0I01880)
NDI: NDAI_0A06480(NDAI0A06480)
TPF: TPHA_0A04340(TPHA0A04340)
TBL: TBLA_0B01660(TBLA0B01660)
TDL: TDEL_0D04380(TDEL0D04380)
KAF: KAFR_0F02320(KAFR0F02320)
PIC: PICST_39084(TSC13)
CAL: CAALFM_C101050CA(CaO19.3293)
CAUR: QG37_05093
SLB: AWJ20_1731(TSC13)
NCR: NCU03362
NTE: NEUTE1DRAFT117529(NEUTE1DRAFT_117529)
MGR: MGG_03250
SSCK: SPSK_00299
MAW: MAC_05645
MAJ: MAA_01851
CMT: CCM_05177
MBE: MBM_02606
ANI: AN1968.2
ANG: ANI_1_968184(An04g05930)
ABE: ARB_02271
TVE: TRV_04982
PNO: SNOG_07392(SNOG_07391)
PTE: PTT_16464
CNE: CNE01780
CNB: CNBE1760
MGL: MGL_0166
DDI: DDB_G0270270(gpsn2)
DFA: DFA_02956(gpsn2)
EHI: EHI_045030(3.t00089)
PYO: PY17X_0914200(PY03009)
PCB: PCHAS_071400(PC000427.01.0)
TAN: TA18840
TPV: TP03_0656
BBO: BBOV_III001830(17.m10668)
CPV: cgd2_1200
SPAR: SPRG_07122
TCR: 457251.10
LMA: LMJF_25_1770(EnCR)
 » show all
Taxonomy
Reference
1  [PMID:11113186]
  Authors
Kohlwein SD, Eder S, Oh CS, Martin CE, Gable K, Bacikova D, Dunn T
  Title
Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae.
  Journal
Mol Cell Biol 21:109-25 (2001)
DOI:10.1128/MCB.21.1.109-125.2001
  Sequence
[sce:YDL015C]
Reference
2  [PMID:14673020]
  Authors
Gable K, Garton S, Napier JA, Dunn TM
  Title
Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system.
  Journal
J Exp Bot 55:543-5 (2004)
DOI:10.1093/jxb/erh061
  Sequence
[ath:AT3G55360]
Reference
3  [PMID:15958487]
  Authors
Kvam E, Gable K, Dunn TM, Goldfarb DS
  Title
Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles.
  Journal
Mol Biol Cell 16:3987-98 (2005)
DOI:10.1091/mbc.e05-04-0290
  Sequence
[sce:YDL015C]
Reference
4  [PMID:15829606]
  Authors
Zheng H, Rowland O, Kunst L
  Title
Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role  for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis.
  Journal
Plant Cell 17:1467-81 (2005)
DOI:10.1105/tpc.104.030155
  Sequence
[ath:AT3G55360]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.93
IUBMB Enzyme Nomenclature: 1.3.1.93
ExPASy - ENZYME nomenclature database: 1.3.1.93
BRENDA, the Enzyme Database: 1.3.1.93

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