KEGG   ENZYME: 1.3.4.1Help
Entry
EC 1.3.4.1                  Enzyme                                 

Name
fumarate reductase (CoM/CoB);
thiol:fumarate reductase;
Tfr
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
fumarate CoM:CoB oxidoreductase (succinate-forming)
Reaction(IUBMB)
fumarate + CoM + CoB = succinate + CoM-S-S-CoB [RN:R10660]
Reaction(KEGG)
Substrate
fumarate [CPD:C00122];
CoM [CPD:C03576];
CoB [CPD:C04628]
Product
succinate [CPD:C00042];
CoM-S-S-CoB [CPD:C04832]
Comment
The enzyme, isolated from the archaeon Methanobacterium thermoautotrophicum, is very oxygen sensitive. It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as an electron donor. Distinct from EC 1.3.1.6 [fumarate reductase (NADH)], EC 1.3.5.1 [succinate dehydrogenase (ubiquinone)], and EC 1.3.5.4 [fumarate reductase (quinol)].
History
EC 1.3.4.1 created 2014 as EC 1.3.98.2, transferred 2014 to EC 1.3.4.1
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01120  Microbial metabolism in diverse environments
Orthology
K18209  fumarate reductase (CoM/CoB) subunit A
K18210  fumarate reductase (CoM/CoB) subunit B
Genes
PSPW: BJG93_06520
RUE: DT065_10055
SPHI: TS85_13175
BACO: OXB_3153
PNP: IJ22_47240
PYG: AWM70_00700
CPOR: BED41_11845
MJA: MJ_0033 MJ_0092
MFE: Mefer_0390 Mefer_1238
MVU: Metvu_1248 Metvu_1286
MMP: MMP1067 MMP1277(frdA)
MMD: GYY_06170 GYY_07220(sdhA)
MMG: MTBMA_c00880(tfrA) MTBMA_c04210(tfrB)
MWO: MWSIV6_0043(tfrA) MWSIV6_0381(tfrB)
METE: tca_01449(nadB) tca_01787(frdB)
MST: Msp_0180(tfrA) Msp_1044(tfrB)
MRU: mru_0088(sdhA) mru_0655(sdhB)
MEB: Abm4_0015(sdhA) Abm4_1340(sdhB)
MMIL: sm9_0007(sdhA) sm9_0612(sdhB)
MEYE: TL18_00105(sdhA) TL18_02920
MFC: BRM9_0092(sdhA) BRM9_0542(sdhB)
MCUB: MCBB_0053(tfrA) MCBB_1554
MKA: MK0132(frdB_glpC) MK0828(sdhA)
MARC: AR505_1127
MBG: BN140_0102(sdhB) BN140_0103(sdhA)
 » show all
Taxonomy
Reference
1  [PMID:2499256]
  Authors
Khandekar SS, Eirich LD
  Title
Purification and characterization of an anabolic fumarate reductase from Methanobacterium thermoautotrophicum.
  Journal
Appl Environ Microbiol 55:856-61 (1989)
Reference
2  [PMID:9578488]
  Authors
Heim S, Kunkel A, Thauer RK, Hedderich R
  Title
Thiol:fumarate reductase (Tfr) from Methanobacterium thermoautotrophicum--identification of the catalytic sites for fumarate reduction and thiol oxidation.
  Journal
Eur J Biochem 253:292-9 (1998)
DOI:10.1046/j.1432-1327.1998.2530292.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.4.1
IUBMB Enzyme Nomenclature: 1.3.4.1
ExPASy - ENZYME nomenclature database: 1.3.4.1
BRENDA, the Enzyme Database: 1.3.4.1

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