KEGG   ENZYME: 1.3.7.1Help
Entry
EC 1.3.7.1                  Enzyme                                 

Name
6-hydroxynicotinate reductase;
6-oxotetrahydronicotinate dehydrogenase;
6-hydroxynicotinic reductase;
HNA reductase;
1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase
Reaction(IUBMB)
6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin [RN:R03164]
Reaction(KEGG)
Substrate
6-oxo-1,4,5,6-tetrahydronicotinate [CPD:C04226];
oxidized ferredoxin [CPD:C00139]
Product
6-hydroxynicotinate [CPD:C01020];
reduced ferredoxin [CPD:C00138]
History
EC 1.3.7.1 created 1972
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K20449  6-hydroxynicotinate reductase
Genes
GAI: IMCC3135_06315(hnr)
BUG: BC1001_4289
BGF: BC1003_5111
BUQ: AC233_28025
BUZ: AYM40_31855
BXE: Bxe_B0654
BXB: DR64_5985(hnr)
BPX: BUPH_00873
BPY: Bphyt_4323
BFN: OI25_6341
POL: Bpro_4068
VEI: Veis_0853
MLO: mll4879
AMIH: CO731_00454(hnr)
ARA: Arad_8284
BJA: blr3822
BRA: BRADO2116
BBT: BBta_2425
BRS: S23_44200
AOL: S58_54180
BRAD: BF49_1223
RPB: RPB_1667
XAU: Xaut_4211
AZC: AZC_2798
MET: M446_1984
MNO: Mnod_1248
HDI: HDIA_4444(Hnr)
RBM: TEF_05290
SIL: SPO0829
RDE: RD1_1534
OTM: OSB_05920
SPSE: SULPSESMR1_04043(hnr)
MAG: amb1482
CPAT: CLPA_c02890(hnr)
CPAE: CPAST_c02890(hnr)
TAE: TepiRe1_0462(Hnr)
 » show all
Taxonomy
Reference
1  [PMID:5767303]
  Authors
Holcenberg JS, Tsai L.
  Title
Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid.
  Journal
J Biol Chem 244:1204-11 (1969)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.1
IUBMB Enzyme Nomenclature: 1.3.7.1
ExPASy - ENZYME nomenclature database: 1.3.7.1
BRENDA, the Enzyme Database: 1.3.7.1
CAS: 9030-84-6

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