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Entry
EC 1.3.7.4                  Enzyme                                 

Name
phytochromobilin:ferredoxin oxidoreductase;
HY2;
PPhi B synthase;
phytochromobilin synthase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
(3Z)-phytochromobilin:ferredoxin oxidoreductase
Reaction(IUBMB)
(3Z)-phytochromobilin + 2 oxidized ferredoxin = biliverdin IXalpha + 2 reduced ferredoxin [RN:R03678]
Reaction(KEGG)
Substrate
(3Z)-phytochromobilin [CPD:C05913];
oxidized ferredoxin [CPD:C00139]
Product
biliverdin IXalpha;
reduced ferredoxin [CPD:C00138]
Comment
Catalyses the two-electron reduction of biliverdin IXalpha. Can use [2Fe-2S] ferredoxins from a number of sources as acceptor but not the [4Fe-4S] ferredoxin from Clostridium pasteurianum. The isomerization of (3Z)-phytochromobilin to (3E)-phytochromobilin is thought to occur prior to covalent attachment to apophytochrome in the plant cell cytoplasm. Flavodoxins can be used instead of ferredoxin.
History
EC 1.3.7.4 created 2002
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K08101  phytochromobilin:ferredoxin oxidoreductase
Genes
ATH: AT3G09150(HY2)
ALY: ARALYDRAFT_478229 ARALYDRAFT_890583
CRB: 17892864
CSAT: 104745078 104749614 104764610
EUS: EUTSA_v10011657mg
BRP: 103859309 103870559
BNA: 106352983 106439211
BOE: 106295900 106331861
THJ: 104799118
CPAP: 110811856
CIT: 102609362
TCC: 18589938
GRA: 105783974
GMX: 100791053
VRA: 106765267
VAR: 108338713
CCAJ: 109795293
LJA: Lj0g3v0050649.1(Lj0g3v0050649.1) Lj2g3v3337330.1(Lj2g3v3337330.1)
ADU: 107496238
AIP: 107609834
LANG: 109342143
FVE: 101309029
PPER: 18778367
PMUM: 103326785
PAVI: 110761571
MDM: 103426911
CSV: 101217650
CMO: 103492001
MCHA: 111021651
CMAX: 111485492
CMOS: 111461368
CPEP: 111779700
RCU: 8261167
JCU: 105647226
HBR: 110634414
JRE: 108994596
VVI: 100267105
SLY: 778324(AUREA)
SPEN: 107008239
SOT: 102604691
CANN: 107875610
NSY: 104250102
NTO: 104118127
INI: 109160056
SIND: 105170921
OEU: 111400840
LSV: 111883501
DCR: 108193224
BVG: 104889193
SOE: 110796859
NNU: 104612006
OSA: 4325761
DOSA: Os01t0949400-01(Os01g0949400)
OBR: 102708119
BDI: 100829998
ATS: 109753420 109784146(LOC109784146)
SBI: 8081332
ZMA: 542164(elm1)
SITA: 101767227
PDA: 103705671
EGU: 105047124
MUS: 103976148
DCT: 110105041
AOF: 109850042
ATR: 18433244
PPP: 112290529
 » show all
Taxonomy
Reference
1  [PMID:11283349]
  Authors
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
  Title
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
  Journal
Plant Cell 13:965-78 (2001)
Reference
2  [PMID:11500553]
  Authors
McDowell MT, Lagarias JC.
  Title
Purification and biochemical properties of phytochromobilin synthase from etiolated oat seedlings.
  Journal
Plant Physiol 126:1546-54 (2001)
Reference
3  [PMID:8215388]
  Authors
Terry MJ, Wahleithner JA, Lagarias JC.
  Title
Biosynthesis of the plant photoreceptor phytochrome.
  Journal
Arch Biochem Biophys 306:1-15 (1993)
DOI:10.1006/abbi.1993.1473
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.4
IUBMB Enzyme Nomenclature: 1.3.7.4
ExPASy - ENZYME nomenclature database: 1.3.7.4
BRENDA, the Enzyme Database: 1.3.7.4
CAS: 138263-99-7

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