KEGG   ENZYME: 1.3.7.8Help
Entry
EC 1.3.7.8                  Enzyme                                 

Name
benzoyl-CoA reductase;
benzoyl-CoA reductase (dearomatizing)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming)
Reaction(IUBMB)
cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 ADP + 2 phosphate = benzoyl-CoA + reduced ferredoxin + 2 ATP + 2 H2O [RN:R02451]
Reaction(KEGG)
R02451;
(other) R00283
Show
Substrate
cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
oxidized ferredoxin [CPD:C00139];
ADP [CPD:C00008];
phosphate [CPD:C00009]
Product
benzoyl-CoA [CPD:C00512];
reduced ferredoxin [CPD:C00138];
ATP [CPD:C00002];
H2O [CPD:C00001]
Comment
An iron-sulfur protein. Requires Mg2+ or Mn2+. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate = hydroxylamine + reduced acceptor + 2 ATP + H2O. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate.
History
EC 1.3.7.8 created 1999 as EC 1.3.99.15, transferred 2011 to EC 1.3.7.8, modified 2011
Pathway
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04112  benzoyl-CoA reductase subunit C
K04113  benzoyl-CoA reductase subunit B
K04114  benzoyl-CoA reductase subunit A
K04115  benzoyl-CoA reductase subunit D
Genes
SPOI: IMCC21906_00682 IMCC21906_00683 IMCC21906_02701
SHD: SUTH_01645(bcrC) SUTH_01646(bcrB) SUTH_01647(bcrD) SUTH_01648(bcrA)
EBA: ebA5282(bcrC) ebA5284(bcrB) ebA5286(bcrD) ebA5287(bcrA) ebA742(bcrA) ebA744(bcrD) ebA746(bcrB) ebA748(bcrC)
AZA: AZKH_2137(bcrC) AZKH_2138(bcrB_bzdO) AZKH_2139(bcrD) AZKH_2140(bcrA_bzdQ) AZKH_p0330 AZKH_p0331
AZI: AzCIB_1603 AzCIB_1605 AzCIB_4492 AzCIB_4493 AzCIB_4620 AzCIB_4621
AZD: CDA09_09240 CDA09_09245 CDA09_12145(bzdQ) CDA09_12150 CDA09_12155(bzdO) CDA09_21825 CDA09_21830 CDA09_22655(bzdO)
TMZ: Tmz1t_2948 Tmz1t_2949 Tmz1t_2950 Tmz1t_2951
TCL: Tchl_2147 Tchl_2148 Tchl_2149 Tchl_2150 Tchl_3426
TAK: Tharo_1305 Tharo_1306 Tharo_1307 Tharo_1308
GLO: Glov_2400 Glov_2401
RPA: RPA0657(badD) RPA0658(badE) RPA0659(badF) RPA0660(badG)
BLAG: BLTE_16500
MAGX: XM1_2273(mbdO) XM1_2893(bcrD) XM1_2894(bcrA) XM1_2895(bcrB) XM1_2896(bcrC) XM1_3815
GOM: D7316_03196(hadB_1) D7316_03204(hadB_2)
 » show all
Taxonomy
Reference
1  [PMID:8575453]
  Authors
Boll M, Fuchs G.
  Title
Benzoyl-coenzyme A reductase (dearomatizing), a key enzyme of anaerobic aromatic metabolism. ATP dependence of the reaction, purification and some properties of the enzyme from Thauera aromatica strain K172.
  Journal
Eur J Biochem 234:921-33 (1995)
DOI:10.1111/j.1432-1033.1995.921_a.x
  Sequence
Reference
2  [PMID:20578740]
  Authors
Kung JW, Baumann S, von Bergen M, Muller M, Hagedoorn PL, Hagen WR, Boll M
  Title
Reversible biological Birch reduction at an extremely low redox potential.
  Journal
J Am Chem Soc 132:9850-6 (2010)
DOI:10.1021/ja103448u
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.8
IUBMB Enzyme Nomenclature: 1.3.7.8
ExPASy - ENZYME nomenclature database: 1.3.7.8
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.7.8
BRENDA, the Enzyme Database: 1.3.7.8
CAS: 176591-18-7

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