KEGG   ENZYME: 1.3.99.12Help
Entry
EC 1.3.99.12                Enzyme                                 

Name
2-methylacyl-CoA dehydrogenase;
branched-chain acyl-CoA dehydrogenase;
2-methyl branched chain acyl-CoA dehydrogenase;
2-methylbutanoyl-CoA:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
2-methylbutanoyl-CoA:acceptor oxidoreductase
Reaction(IUBMB)
2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor [RN:R03173]
Reaction(KEGG)
R03173 > R03172;
(other) R02661
Show
Substrate
2-methylbutanoyl-CoA [CPD:C01033];
acceptor [CPD:C00028]
Product
2-methylbut-2-enoyl-CoA [CPD:C03345];
reduced acceptor [CPD:C00030]
Comment
Also oxidizes 2-methylpropanoyl-CoA. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.8.7 (medium-chain acyl-CoA dehydrogenase), EC 1.3.8.8 (long-chain acyl-CoA dehydrogenase), EC 1.3.8.9 (very-long-chain acyl-CoA dehydrogenase) or EC 1.3.99.10 (isovaleryl-CoA dehydrogenase).
History
EC 1.3.99.12 created 1986
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09478  short/branched chain acyl-CoA dehydrogenase
K11410  short/branched chain acyl-CoA dehydrogenase
Genes
HSA: 36(ACADSB)
PTR: 745464(ACADSB)
PPS: 100991276(ACADSB)
GGO: 101132470(ACADSB)
PON: 100171571(ACADSB)
NLE: 100603582(ACADSB)
MCC: 707487(ACADSB)
MCF: 102133754(ACADSB)
CSAB: 103216651(ACADSB)
RRO: 104658093(ACADSB)
RBB: 108519576(ACADSB)
CJC: 100396089(ACADSB)
SBQ: 101028121(ACADSB)
MMU: 66885(Acadsb)
RNO: 25618(Acadsb)
CGE: 100766828(Acadsb)
NGI: 103729261(Acadsb)
HGL: 101698912(Acadsb)
CCAN: 109691642(Acadsb)
OCU: 100351868(ACADSB)
TUP: 102474463(ACADSB)
CFA: 477856(ACADSB)
AML: 100470228(ACADSB)
UMR: 103657958(ACADSB)
ORO: 101373794(ACADSB)
FCA: 101092794(ACADSB)
PTG: 102951023(ACADSB)
AJU: 106969392(ACADSB)
BTA: 504301(ACADSB)
BOM: 102266366(ACADSB)
BIU: 109579124(ACADSB)
PHD: 102329883
CHX: 102177588(ACADSB)
OAS: 101102606(ACADSB)
SSC: 100154810(ACADSB)
CFR: 102517479(ACADSB)
CDK: 105085769(ACADSB)
BACU: 102999342(ACADSB)
LVE: 103077062(ACADSB)
OOR: 101289781(ACADSB)
ECB: 100057998(ACADSB)
EAI: 106847757(ACADSB)
MYB: 102253452(ACADSB)
MYD: 102769159(ACADSB)
HAI: 109396916(ACADSB)
RSS: 109436395(ACADSB)
PALE: 102891849(ACADSB)
LAV: 100658432(ACADSB)
TMU: 101353141
MDO: 100025277(ACADSB)
SHR: 100925751(ACADSB)
OAA: 100086999(ACADSB)
GGA: 423947(ACADSB)
MGP: 100542282(ACADSB)
CJO: 107316256(ACADSB)
APLA: 101793844(ACADSB)
ACYG: 106038988(ACADSB)
TGU: 100217590(ACADSB)
GFR: 102040450(ACADSB)
FAB: 101819094(ACADSB)
PHI: 102100927(ACADSB)
PMAJ: 107206820(ACADSB)
CCW: 104694570(ACADSB)
FPG: 101917969(ACADSB)
FCH: 102057808(ACADSB)
CLV: 102096980(ACADSB)
EGZ: 104128327(ACADSB)
AAM: 106494200(ACADSB)
ASN: 102386096(ACADSB)
AMJ: 102577069(ACADSB)
PSS: 102458654(ACADSB)
CMY: 102942130(ACADSB)
CPIC: 101938408(ACADSB)
ACS: 100556766(acadsb)
PVT: 110087224(ACADSB)
PBI: 103066261(ACADSB)
GJA: 107116296(ACADSB)
XLA: 494679(acadsb.L)
XTR: 448259(acadsb)
NPR: 108784780(ACADSB)
DRE: 100037342(acadsb)
SRX: 107746745
SANH: 107684586
IPU: 108273611(acadsb)
AMEX: 103042655(acadsb)
TRU: 101075946(acadsb)
LCO: 104926628(acadsb)
NCC: 104954036(acadsb)
MZE: 101471898(acadsb)
OLA: 101163855(acadsb)
XMA: 102220838(acadsb)
PRET: 103481581(acadsb)
NFU: 107387801(acadsb)
CSEM: 103381955(acadsb)
LCF: 108899015(acadsb)
HCQ: 109523983(acadsb)
BPEC: 110165473(acadsb)
ELS: 105009552(acadsb)
SFM: 108939566(acadsb)
LCM: 102365761(ACADSB)
CMK: 103185437(acadsb)
APLC: 110988182
SKO: 100378591
DME: Dmel_CG3902(CG3902)
DSI: Dsimw501_GD12323(Dsim_GD12323)
MDE: 101890297
AAG: 5569333
AME: 409712
BIM: 100749552
BTER: 100649947
SOC: 105200366
AEC: 105143927
PBAR: 105428815
CFO: 105250026
LHU: 105674413
PGC: 109859061
DPA: 109540223
BMOR: 733139(Acade)
PMAC: 106716140
PRAP: 111002788
PXY: 105383530
API: 100161123
DNX: 107163553
ZNE: 110839588
FCD: 110852222
CEL: CELE_C55B7.4(acdh-1) CELE_K06A5.6(acdh-3) CELE_T10E9.9(acdh-4)
CBR: CBG12633 CBG12644(Cbr-acdh-1) CBG12664
TSP: Tsp_04649
CRG: 105329007
MYI: 110442658
OBI: 106881672
LAK: 106173907
EPA: 110246509
ADF: 107338768
HMG: 100205931
AQU: 100640316
DDI: DDB_G0282967(acadsb)
DFA: DFA_08597(acadsb)
SMIN: v1.2.033419.t1(symbB.v1.2.033419.t1)
FCY: FRACYDRAFT_187779(ACD2)
TPS: THAPSDRAFT_269127(ACD3)
SPAR: SPRG_03679
SCO: SCO2779(acdH)
SMA: SAVERM_5275(fadE4)
SGR: SGR_4756
SGB: WQO_11760
SCB: SCAB_58001(acdH)
SCT: SCAT_1857(yngJ)
SFA: Sfla_4110
SBH: SBI_06919
SHY: SHJG_4280
SVE: SVEN_2568
SDV: BN159_5499(yngJ1)
SALB: XNR_4209
SALS: SLNWT_2338
STRP: F750_2606
SFI: SFUL_2370
SALU: DC74_3256
SALL: SAZ_17345
STRE: GZL_05657
SLD: T261_5312
STRM: M444_13330
SAMB: SAM23877_2814(yngJ)
SPRI: SPRI_4763
SRW: TUE45_03394(mmgC_7)
SLE: sle_44610(sle_44610)
SRN: A4G23_01831(mmgC_3)
STRD: NI25_24960
SMAL: SMALA_2810
SLAU: SLA_2529
SALF: SMD44_03078(acdH)
SALJ: SMD11_4398(acdH)
SLX: SLAV_23940(mmgC10)
SFK: KY5_2919
KSK: KSE_26850(fadE3)
MMAR: MODMU_1452
 » show all
Taxonomy
Reference
1  [PMID:6401712]
  Authors
Ikeda Y, Dabrowski C, Tanaka K.
  Title
Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase.
  Journal
J Biol Chem 258:1066-76 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.12
IUBMB Enzyme Nomenclature: 1.3.99.12
ExPASy - ENZYME nomenclature database: 1.3.99.12
BRENDA, the Enzyme Database: 1.3.99.12
CAS: 85130-32-1

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