KEGG   ENZYME: 1.3.99.16Help
Entry
EC 1.3.99.16                Enzyme                                 

Name
isoquinoline 1-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
isoquinoline:acceptor 1-oxidoreductase (hydroxylating)
Reaction(IUBMB)
isoquinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor [RN:R05151]
Reaction(KEGG)
Substrate
isoquinoline [CPD:C06323];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
isoquinolin-1(2H)-one [CPD:C06324];
reduced acceptor [CPD:C00030]
Comment
The enzyme from Pseudomonas diminuta is specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline. Electron acceptors include 1,2-benzoquinone, cytochrome c, ferricyanide, iodonitrotetrazolium chloride, nitroblue tetrazolium, Meldola blue and phenazine methosulfate.
History
EC 1.3.99.16 created 1999
Orthology
K00256  isoquinoline 1-oxidoreductase
K07302  isoquinoline 1-oxidoreductase subunit alpha
K07303  isoquinoline 1-oxidoreductase subunit beta
Genes
EBT: EBL_c15000 EBL_c15010
SPE: Spro_2319 Spro_2320
SRR: SerAS9_2278 SerAS9_2279
SRL: SOD_c21500 SOD_c21510(iorA)
SRY: M621_11780
SPLY: Q5A_011915(iorB) Q5A_011920(iorA)
SRS: SerAS12_2278 SerAS12_2279
SRA: SerAS13_2279 SerAS13_2280
SMAF: D781_2567 D781_2568
SMW: SMWW4_v1c23370 SMWW4_v1c23380
PPSE: BN5_4313(iorB) BN5_4314(iorA3)
PCQ: PcP3B5_29960(iorA) PcP3B5_29970(iorB)
PPU: PP_2477(iorA-I) PP_2478 PP_3621(iorA-II) PP_3622
PPX: T1E_1805(iorB) T1E_1806(iorA)
PFL: PFL_1783(iorA) PFL_1784(iorB)
PPRC: PFLCHA0_c18200(iorA) PFLCHA0_c18210(iorB)
PPRO: PPC_1831(iorA) PPC_1832(iorB)
PFC: PflA506_2213(iorB) PflA506_2214(iorA)
PPUU: PputUW4_02893(iorB1) PputUW4_02894(iorA1) PputUW4_04045(iorB2) PputUW4_04046(iorA2)
PSES: PSCI_3414(iorA) PSCI_3415
SVO: SVI_2824 SVI_2825(iorA)
CPS: CPS_0277(iorB) CPS_0278(iorA)
PIN: Ping_1831
HBE: BEI_0468(iorA1) BEI_0469(iorB1) BEI_1453(iorB2) BEI_1454(iorA2)
ADI: B5T_03641 B5T_03642(iorA)
SVA: SVA_1079
RSC: RCFBP_11442(iorA) RCFBP_11443(iorB)
RSN: RSPO_c01500(iorA2) RSPO_c01501(iorB2) RSPO_m01494(iorB) RSPO_m01495(iorA)
REH: H16_A0700(coxS2) H16_A0701(coxL2) H16_A1652(iorB1) H16_A1653(iorA1) H16_B1377(coxL6) H16_B1378(coxS6) H16_B1523(iorB2) H16_B1524(iorA2)
CNC: CNE_1c06950(coxS2) CNE_1c06960(coxL2) CNE_1c16750(iorB2) CNE_1c16760(iorA2) CNE_2c13350(coxL) CNE_2c13360(coxS) CNE_BB1p05060(iorA1) CNE_BB1p05070(iorB1) CNE_BB1p05270(iorA2) CNE_BB1p05280(iorB2) CNE_BB1p05640(iorB3) CNE_BB1p05650(iorA3)
RME: Rmet_0594(iorA) Rmet_0595(iorB)
BMA: BMAA1154(iorA) BMAA1154.1(iorB)
BML: BMA10229_0085(iorB) BMA10229_0086(iorA)
BMN: BMA10247_A1530(iorA) BMA10247_A1531(iorB)
BMJ: BMULJ_01133(coxS) BMULJ_01134(coxL) BMULJ_01280(iorA) BMULJ_01281(coxL) BMULJ_01550(iorA) BMULJ_01551(iorB)
BGP: BGL_2c03680(iorA) BGL_2c03690(iorB)
BPT: Bpet2927(iorA1) Bpet2928(iorB1) Bpet4125(iorB2) Bpet4126(iorA2)
BHZ: ACR54_01148(iorB) ACR54_01149(iorA)
AXX: ERS451415_04192(iorB) ERS451415_04193(iorA_2)
AMIM: MIM_c02290(iorA1) MIM_c02300(iorB1) MIM_c31190(iorB2) MIM_c31200(iorA2)
AAV: Aave_3932
LIH: L63ED372_01901(iorA_1) L63ED372_01902(iorB_1) L63ED372_02634(iorA_2) L63ED372_02635(iorB_2)
HAR: HEAR1179(iorA) HEAR1180(iorB)
MMS: mma_0765 mma_0766(coxS)
CFU: CFU_0189(iorA) CFU_0190(iorB) CFU_2290 CFU_2291(iorB2)
RGE: RGE_23230(iorA) RGE_23240(iorB)
MEP: MPQ_1444(coxL) MPQ_1445(coxS)
AZO: azo0021(iorA) azo0022(iorB)
AZA: AZKH_1473(iorA) AZKH_1474(iorB) AZKH_3901(iorB) AZKH_3902(iorB)
DPI: BN4_11166(iorA) BN4_11167(iorB)
MXA: MXAN_1751(iorA) MXAN_1752(iorB) MXAN_4829(iorB) MXAN_4830(iorA)
CCX: COCOR_01427(iorA) COCOR_01428(iorB) COCOR_03693(iorA1) COCOR_03694(iorB1)
SFH: SFHH103_05020(iorB) SFHH103_05021(iorA)
SFD: USDA257_c23010(iorB) USDA257_c23020(iorA1)
RLE: RL2499(iorA) RL2500(iorB)
HDI: HDIA_0049(iorA_1) HDIA_0050(iorB_1) HDIA_1733(iorA_2) HDIA_1734 HDIA_3138(iorB_2) HDIA_3139(iorA_3) HDIA_P0068(iorA_4) HDIA_P0069(iorB_3)
PZU: PHZ_c3051(iorB) PHZ_c3052(iorA)
SIL: SPO2826(iorA) SPO2827
RDE: RD1_0246(iorA) RD1_0247(iorB) RD1_A0087 RD1_A0088(iorA)
RLI: RLO149_c043160(iorA) RLO149_c043170(iorB)
KRO: BVG79_00087(iorA)
PGA: PGA1_c09930(iorB) PGA1_c09950(iorA)
PGL: PGA2_c09810(iorB) PGA2_c09820(iorA)
PHP: PhaeoP97_00965(iorB) PhaeoP97_00966(iorA)
PPIC: PhaeoP14_00912(iorB) PhaeoP14_00913(iorA)
OAT: OAN307_c22410(iorA) OAN307_c22420(iorB)
OTM: OSB_13580(nicA) OSB_13590(iorB)
SGI: SGRAN_3036(iorA2) SGRAN_3752
SPHU: SPPYR_2303(iorA) SPPYR_3298
AAY: WYH_01540(nicA) WYH_02804(iorB_1) WYH_03189(iorA) WYH_03190(iorB_2)
ANH: A6F65_00810(iorB) A6F65_02477(nicA)
ADO: A6F68_00153(iorB)
GOX: GOX0586
GDI: GDI1785(iorA) GDI1786(iorB) GDI3280
GXY: GLX_05950
MAG: amb4196
MAGX: XM1_1197 XM1_1198(iorA)
ALI: AZOLI_p50066(iorA) AZOLI_p50067(iorB)
ABS: AZOBR_p410086(iorB) AZOBR_p410087(iorA)
MAGQ: MGMAQ_0171(iorB) MGMAQ_0172(iorA)
SPRI: SPRI_6784
SLE: sle_64250(sle_64250) sle_64260(sle_64260)
SNR: SNOUR_36610(iorB) SNOUR_36615(iorA)
SLX: SLAV_33070(iorB) SLAV_33075(iorA)
NDK: I601_0886(iorA) I601_0887(iorB)
SEN: SACE_2974(iorA) SACE_2975(iorB)
AMQ: AMETH_4927(iorA) AMETH_4928(iorB)
CAG: Cagg_2899
TTR: Tter_2354
ABAC: LuPra_02190(iorA_1) LuPra_02191(iorB_1) LuPra_02508(iorA_2) LuPra_02509(iorB_2) LuPra_04628(iorB_3) LuPra_04629(iorA_3)
AAE: aq_227(aldH2)
 » show all
Taxonomy
Reference
1  [PMID:8157655]
  Authors
Lehmann M, Tshisuaka B, Fetzner S, Roger P, Lingens F.
  Title
Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase.
  Journal
J Biol Chem 269:11254-60 (1994)
  Sequence
Reference
2  [PMID:7782304]
  Authors
Lehmann M, Tshisuaka B, Fetzner S, Lingens F.
  Title
Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases.
  Journal
J Biol Chem 270:14420-9 (1995)
DOI:10.1074/jbc.270.24.14420
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.16
IUBMB Enzyme Nomenclature: 1.3.99.16
ExPASy - ENZYME nomenclature database: 1.3.99.16
BRENDA, the Enzyme Database: 1.3.99.16
CAS: 155948-73-5

DBGET integrated database retrieval system