KEGG   ENZYME: 1.3.99.32Help
Entry
EC 1.3.99.32                Enzyme                                 

Name
glutaryl-CoA dehydrogenase (acceptor);
GDHDes;
nondecarboxylating glutaryl-coenzyme A dehydrogenase;
nondecarboxylating glutaconyl-coenzyme A-forming GDH;
glutaryl-CoA dehydrogenase (non-decarboxylating)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating)
Reaction(IUBMB)
glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor [RN:R05579]
Reaction(KEGG)
Substrate
glutaryl-CoA [CPD:C00527];
acceptor [CPD:C00028]
Product
(E)-glutaconyl-CoA [CPD:C02411];
reduced acceptor [CPD:C00030]
Comment
The enzyme contains FAD. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.
History
EC 1.3.99.32 created 2012, modified 2013
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K16173  glutaryl-CoA dehydrogenase (non-decarboxylating)
Genes
GBM: Gbem_1452
GEO: Geob_0237
GEM: GM21_2801
DAL: Dalk_0058
DAT: HRM2_38550(acd11) HRM2_38670(acd12)
DTO: TOL2_C38270(acdA5)
SAT: SYN_00480
DTI: Desti_2252 Desti_4873
DBR: Deba_2447
BAG: Bcoa_0791
AFL: Aflv_1240(acdA)
CHY: CHY_1737
 » show all
Taxonomy
Reference
1  [PMID:19395484]
  Authors
Wischgoll S, Taubert M, Peters F, Jehmlich N, von Bergen M, Boll M
  Title
Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the  aromatic metabolism of obligately anaerobic bacteria.
  Journal
J Bacteriol 191:4401-9 (2009)
DOI:10.1128/JB.00205-09
  Sequence
Reference
2  [PMID:20486657]
  Authors
Wischgoll S, Demmer U, Warkentin E, Gunther R, Boll M, Ermler U
  Title
Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases.
  Journal
Biochemistry 49:5350-7 (2010)
DOI:10.1021/bi100317m
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.32
IUBMB Enzyme Nomenclature: 1.3.99.32
ExPASy - ENZYME nomenclature database: 1.3.99.32
BRENDA, the Enzyme Database: 1.3.99.32

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