KEGG   ENZYME: 1.4.1.15Help
Entry
EC 1.4.1.15                 Enzyme                                 

Name
lysine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)
Reaction(IUBMB)
L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH + H+ [RN:R00445]
Reaction(KEGG)
R00445;
(other) R00145 R00146
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Substrate
L-lysine [CPD:C00047];
NAD+ [CPD:C00003]
Product
1,2-didehydropiperidine-2-carboxylate [CPD:C04092];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.4.1.15 created 1978
Reference
1  [PMID:4291003]
  Authors
Burgi W, Richterich R, Colombo JP.
  Title
L-Lysine dehydrogenase deficiency in a patient with congenital lysine intolerance.
  Journal
Nature 211:854-5 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.15
IUBMB Enzyme Nomenclature: 1.4.1.15
ExPASy - ENZYME nomenclature database: 1.4.1.15
BRENDA, the Enzyme Database: 1.4.1.15
CAS: 68073-29-0

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