KEGG   ENZYME: 1.4.1.21Help
Entry
EC 1.4.1.21                 Enzyme                                 

Name
aspartate dehydrogenase;
NAD-dependent aspartate dehydrogenase;
NADH2-dependent aspartate dehydrogenase;
NADP+-dependent aspartate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-aspartate:NAD(P)+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+ [RN:R07164 R07165]
Reaction(KEGG)
Substrate
L-aspartate [CPD:C00049];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
oxaloacetate [CPD:C00036];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is strictly specific for L-aspartate as substrate. Catalyses the first step in NAD biosynthesis from aspartate. The enzyme has a higher affinity for NAD+ than NADP+ [1].
History
EC 1.4.1.21 created 2005
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
Orthology
K06989  aspartate dehydrogenase
Genes
HSA: 554235(ASPDH)
PTR: 468963(ASPDH)
PPS: 100991588(ASPDH)
GGO: 101135648(ASPDH)
PON: 100458998(ASPDH)
NLE: 100582846(ASPDH)
MCC: 719609(ASPDH)
MCF: 102127481(ASPDH)
CSAB: 103235088(ASPDH)
RRO: 104667233(ASPDH)
RBB: 108535792(ASPDH)
CJC: 100398830(ASPDH)
SBQ: 101043066(ASPDH)
MMU: 68352(Aspdh)
RNO: 292875(Aspdh)
CGE: 100755598(Aspdh)
NGI: 103743703(Aspdh)
HGL: 101725004
CCAN: 109683860(Aspdh)
TUP: 102486263(ASPDH)
CFA: 611841(ASPDH)
AML: 100484510(ASPDH)
UMR: 103657276(ASPDH)
ORO: 101373096(ASPDH)
FCA: 101099166(ASPDH)
PTG: 102961245(ASPDH)
AJU: 106983134(ASPDH)
BOM: 102284425(ASPDH)
BIU: 109571906
PHD: 102342374(ASPDH)
CHX: 102176455(ASPDH)
OAS: 101118046(ASPDH)
SSC: 100511638(ASPDH)
CFR: 102516988(ASPDH)
CDK: 105100165(ASPDH)
BACU: 103008927(ASPDH)
LVE: 103083700(ASPDH)
OOR: 101285253(ASPDH)
ECB: 111775246(ASPDH)
EPZ: 103543350(ASPDH)
EAI: 106845486(ASPDH)
MYB: 102247701(ASPDH)
MYD: 102767203(ASPDH)
HAI: 109391040(ASPDH)
RSS: 109452564(ASPDH)
PALE: 102878612(ASPDH)
TMU: 101343021
SHR: 100935136(ASPDH)
GGA: 101749079(ASPDH)
MGP: 104917106(ASPDH)
CJO: 107307151(ASPDH)
PHI: 102108482(ASPDH)
ASN: 102379311(ASPDH)
AMJ: 102562574(ASPDH)
PSS: 102452013(ASPDH)
CPIC: 101932416(ASPDH)
ACS: 100563350(aspdh)
PVT: 110086937(ASPDH)
PBI: 103054992(ASPDH)
GJA: 107115523(ASPDH)
XLA: 108697271(aspdh.S)
XTR: 548417(aspdh)
NPR: 108794232(ASPDH)
DRE: 447919(aspdh)
SANH: 107690305(aspdh)
SGH: 107560744 107567544(aspdh)
CCAR: 109069550(aspdh)
IPU: 100529011(aspdh)
AMEX: 103022704(aspdh)
TRU: 101077325(aspdh)
LCO: 104930341(aspdh) 109136720
NCC: 104942713(aspdh)
MZE: 101485812(aspdh)
OLA: 101155692(aspdh)
XMA: 102224340(aspdh)
PRET: 103469091(aspdh)
NFU: 107376659(aspdh)
CSEM: 103392976(aspdh)
LCF: 108881011(aspdh)
HCQ: 109514857(aspdh)
BPEC: 110158220(aspdh)
ELS: 105007708(aspdh)
SFM: 108941640(aspdh)
LCM: 102359378(ASPDH)
CIN: 100184692
SPU: 585815
APLC: 110982300
SKO: 100369721
CEL: CELE_F17C8.9(F17C8.9)
CBR: CBG17998
CRG: 105333864
MYI: 110458570
ADF: 107328243
HMG: 100203319
ENC: ECL_04254
ECLO: ENC_31770
EEC: EcWSU1_03724(nadX)
ECLX: LI66_18645
ECLY: LI62_20105
ECLZ: LI64_17535
KPN: KPN_03362
KPR: KPR_4627(aspD)
KPJ: N559_0875
KPNU: LI86_04285
EAE: EAE_03000
EAR: CCG33381
EBF: D782_0775
YRO: CH64_1868
SPE: Spro_3958
SRL: SOD_c39140(nadX)
SPLY: Q5A_020975(nadX)
SMAF: D781_3679
SMAR: SM39_3550
SERF: L085_08165
PSI: S70_18990
PSX: DR96_2715
PRG: RB151_040040(nadX)
LRI: NCTC12151_00054(nadX)
PAE: PA3505
PAEV: N297_3628
PAEI: N296_3628
PAEC: M802_3627
PAEO: M801_3493
PRE: PCA10_15620(nadX)
PCQ: PcP3B5_08000(nadX)
PSIL: PMA3_18860
ACB: A1S_0956
ABY: ABAYE2838
ABN: AB57_1031
ABX: ABK1_0941
ABH: M3Q_1254
ABAD: ABD1_09080
ABAZ: P795_12930
ABAA: IX88_06785
ACC: BDGL_000233(nadX)
ACI: ACIAD0997
PHA: PSHAb0019
GAI: IMCC3135_20465(nadX)
CSA: Csal_0141
HCO: LOKO_02885(nadX)
HBE: BEI_0086(nadX)
RSO: RSp0722
RSL: RPSI07_mp0621(nadX)
RSN: RSPO_m01055(nadX)
RSM: CMR15_mp10693(nadX)
RSE: F504_4495
RPI: Rpic_4503
REH: H16_B0736(h16_B0736)
CNC: CNE_2c06790(nadX)
CTI: RALTA_B0572(nadX)
BMA: BMAA1329
BMAL: DM55_4193
BMAE: DM78_3324
BMAQ: DM76_4893
BMAI: DM57_10405
BMAF: DM51_4982
BMAZ: BM44_4157
BMAB: BM45_3279
BPS: BPSS0903
BPSE: BDL_4191
BPSM: BBQ_5234
BPSU: BBN_4362
BPSD: BBX_6031
BPK: BBK_3535
BPSH: DR55_4433
BPSA: BBU_5128
BPSO: X996_4139
BUT: X994_6222
BTQ: BTQ_4781
BTJ: BTJ_3413
BTZ: BTL_4261
BTD: BTI_5722
BTV: BTHA_3696
BTHE: BTN_3430
BTHM: BTRA_4181
BTHA: DR62_3503
BTHL: BG87_4237
BOK: DM82_5076
BOC: BG90_5519
BCN: Bcen_3665
BCJ: BCAM1845
BCEN: DM39_5965
BCEW: DM40_4673
BCEO: I35_5723
BAM: Bamb_4096
BMU: Bmul_3991
BMK: DM80_5299
BMUL: NP80_4617
BCT: GEM_3772
BCED: DM42_6105
BDL: AK34_3789
BCON: NL30_02835
BUB: BW23_5498
BLAT: WK25_25800
BTEI: WS51_06760
BSEM: WJ12_29350
BPSL: WS57_04780
BSTG: WT74_28390
BGO: BM43_4782
BUE: BRPE67_CCDS00790(nadX)
BUL: BW21_5409
BXE: Bxe_B0182
BXB: DR64_5528
BPH: Bphy_4240
PPNO: DA70_10545
PPNM: LV28_20515
PPUL: RO07_14810
PSPU: NA29_22330
BAV: BAV2441
BHO: D560_2985
BHM: D558_2961
BHZ: ACR54_01428(nadX)
BTRM: SAMEA390648704134(nadX)
AXX: ERS451415_04045(nadX)
PUT: PT7_3205
ODI: ODI_R3090
POL: Bpro_3686
DAC: Daci_0952
VPD: VAPA_1c32530(nadX)
CTES: O987_27360
CARE: LT85_0538
MES: Meso_0824
AMIH: CO731_02616(nadX)
AVI: Avi_9150
OAN: Oant_4396
OAH: DR92_3848
BJA: bll6567
BRS: S23_17600
BRAD: BF49_5096
VGO: GJW-30_1_01281(nadX)
AZC: AZC_4388
MMED: Mame_03212(nadX)
HDI: HDIA_2157(nadX)
CAK: Caul_5291
SIL: SPO2880
JAN: Jann_1451
RDE: RD1_3642
PDE: Pden_1041
DSH: Dshi_0239(nadX)
KVU: EIO_1806
KVL: KVU_1272
PSF: PSE_1841
PGD: Gal_04118
OTM: OSB_07960(nadX)
CID: P73_2157
MALG: MALG_04776
RMM: ROSMUCSMR3_01810(nadX)
AHT: ANTHELSMS3_02149(nadX)
SPHP: LH20_03880
SGI: SGRAN_3560(nadX)
SSAN: NX02_18995
SPKC: KC8_11550
BACO: OXB_3514
BEO: BEH_13495
LYZ: DCE79_14840(nadX)
PSAB: PSAB_06900
SIV: SSIL_0567
SPOS: DV702_10780(nadX)
FPA: FPR_28370
CPY: Cphy_2124
ERH: ERH_0204
CGT: cgR_1126
CAMG: CAMM_08855
RRT: 4535765_04095(nadX)
SALB: XNR_0361
SPRI: SPRI_6557
STRD: NI25_24750
SFK: KY5_1481
ARR: ARUE_c20700(nadX)
ARX: ARZXY2_1986(nadX)
AAU: AAur_1938
BLIN: BLSMQ_3174
STI: Sthe_2207
BVU: BVU_0071
BXY: BXY_25590
BOA: Bovatus_03408(nadX)
BCEL: BcellWH2_00602(nadX)
PSAC: PSM36_0473
FBA: FIC_01249
TMA: TM1643
TMW: THMA_1684
TMQ: THMB_1684
TMX: THMC_1684
TPT: Tpet_1148
TRQ: TRQ2_1186
TNA: CTN_0745
TNP: Tnap_1163
TME: Tmel_1582
TAF: THA_1920
THER: Y592_08465
MARN: LN42_06965
MJA: MJ_0915
MMP: MMP0737
MMD: GYY_02555
MAE: Maeo_0848
MVO: Mvol_0924
MTH: MTH_973
MMG: MTBMA_c13590(nadX)
METC: MTCT_0884
MWO: MWSIV6_1362(nadX)
METE: tca_00936(nadX)
MST: Msp_1148
MSI: Msm_0464
MRU: mru_0675
MEB: Abm4_0406(nadX1) Abm4_1625(nadX2)
MMIL: sm9_0549
MEYE: TL18_02580
MOL: YLM1_0320
METH: MBMB1_1584(nadX)
MFC: BRM9_0819
MFI: DSM1535_0782(nadX)
MCUB: MCBB_0898(nadX_1) MCBB_1882(nadX_3)
MFV: Mfer_0043
MKA: MK0094
AFU: AF_1838
FPL: Ferp_0170
MEAR: Mpt1_c00970(nadX)
MARC: AR505_0143
ABI: Aboo_0362
MAC: MA_0958
MBAR: MSBR2_1572
MBAK: MSBR3_1577
MMA: MM_2072
MMAC: MSMAC_1806
METM: MSMTP_2527
MTHE: MSTHC_1958
MTHR: MSTHT_1334
MHOR: MSHOH_3277
MBU: Mbur_1681
MMET: MCMEM_2162
MMH: Mmah_1981
MPY: Mpsy_1281
MTP: Mthe_0242
MCJ: MCON_1163
MHI: Mhar_0006
MHU: Mhun_2354
MLA: Mlab_0766
MEMA: MMAB1_1143(nadX)
MPI: Mpet_2710
MBN: Mboo_0500
MPD: MCP_1121(nadX)
MEZ: Mtc_1071(nadX)
RCI: RCIX226(nadX)
IHO: Igni_1349
HBU: Hbut_0678
PYR: P186_0988
NMR: Nmar_1240
NID: NPIRD3C_0870(nadX)
NIN: NADRNF5_0703(nadX)
NCT: NMSP_0435(nadX)
NGA: Ngar_c18470(nadX)
NVN: NVIE_003700(nadX)
NEV: NTE_01698
TAA: NMY3_03096(nadX)
NCV: NCAV_0858(nadX)
NBV: T478_0473(nadX)
NDV: NDEV_1222(nadX)
 » show all
Taxonomy
Reference
1  [PMID:12496312]
  Authors
Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L.
  Title
Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643.
  Journal
J Biol Chem 278:8804-8 (2003)
DOI:10.1074/jbc.M211892200
  Sequence
[tma:TM1643]
Reference
2  [PMID:9819709]
  Authors
Okamura T, Noda H, Fukuda S, Ohsugi M.
  Title
Aspartate dehydrogenase in vitamin B12-producing Klebsiella pneumoniae IFO 13541.
  Journal
J Nutr Sci Vitaminol (Tokyo) 44:483-90 (1998)
Reference
3
  Authors
Kretovich, W.L., Kariakina, T.I., Weinova, M.K., Sidelnikova, L.I. and Kazakova, O.W.
  Title
The synthesis of aspartic acid in Rhizobium lupini bacteroids.
  Journal
Plant Soil 61:145-156 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.21
IUBMB Enzyme Nomenclature: 1.4.1.21
ExPASy - ENZYME nomenclature database: 1.4.1.21
BRENDA, the Enzyme Database: 1.4.1.21
CAS: 37278-97-0

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