KEGG   ENZYME: 1.4.1.23Help
Entry
EC 1.4.1.23                 Enzyme                                 

Name
valine dehydrogenase (NAD+)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-valine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH + H+ [RN:R01434]
Reaction(KEGG)
Substrate
L-valine [CPD:C00183];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
3-methyl-2-oxobutanoate [CPD:C00141];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC 1.4.1.8, valine dehydrogenase (NADP+)].
History
EC 1.4.1.23 created 2012
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00271  valine dehydrogenase (NAD+)
Genes
MYV: G155_25940
MFT: XA26_52600
ASD: AS9A_2940
NCY: NOCYR_1282(vdh)
NSL: BOX37_22850
NSR: NS506_07055
RHA: RHA1_ro01628
RER: RER_40180(vdh)
REY: O5Y_18650
REB: XU06_18805
ROP: ROP_13250(vdh)
RHB: NY08_1997
RFA: A3L23_00329(vdh)
RHS: A3Q41_03078(vdh)
RRT: 4535765_04132(vdh)
SCO: SCO4089(SCD25.25c)
SMA: SAVERM_4132(vdh)
SGR: SGR_3880
SGB: WQO_16310
SCB: SCAB_47881(vdh)
SCT: SCAT_3355(vdh)
SFA: Sfla_3000
SBH: SBI_05732
SHY: SHJG_5008
SVE: SVEN_3844
SDV: BN159_4703(vdh)
SALB: XNR_2839
SALS: SLNWT_3941
STRP: F750_3772
SFI: SFUL_3855
SALU: DC74_4008
SALL: SAZ_21190
SLV: SLIV_17980(vdh)
SGU: SGLAU_16260(vdh)
STRE: GZL_04879
SLD: T261_4453
STRM: M444_16950
SAMB: SAM23877_3591(vdh)
SPRI: SPRI_3940
SRW: TUE45_03647(vdh_3)
SLE: sle_37550(sle_37550)
SRN: A4G23_02617(vdh_1)
SNR: SNOUR_22285(vdh)
STRD: NI25_20165
SMAL: SMALA_4135
SLAU: SLA_3928
SALF: SMD44_04086(vdh)
SALJ: SMD11_3646(vdh)
SLX: SLAV_18280(vdh2)
SFK: KY5_3884
KSK: KSE_41600(vdh)
NCA: Noca_4313
NDK: I601_0879(vdh)
PSIM: KR76_25220
TCU: Tcur_0296
SRO: Sros_8995
FAL: FRAAL0132(vdh)
GOB: Gobs_4753
MMAR: MODMU_5123(vdh)
AMD: AMED_6963
AMN: RAM_35720
AMM: AMES_6856
AMZ: B737_6856
AOI: AORI_1764
AJA: AJAP_30675(vdh)
AMQ: AMETH_5418(gdhA1)
SAQ: Sare_0168
MIL: ML5_0206
AMS: AMIS_1270
ASE: ACPL_241(vdh)
ACTN: L083_0144(vdh)
AFS: AFR_00765
ACTS: ACWT_0126
CAI: Caci_0299
SNA: Snas_5981
TBI: Tbis_3346
 » show all
Taxonomy
Reference
1  [PMID:3182727]
  Authors
Vancurova I, Vancura A, Volc J, Neuzil J, Flieger M, Basarova G, Behal V.
  Title
Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens.
  Journal
J Bacteriol 170:5192-6 (1988)
DOI:10.1128/JB.170.11.5192-5196.1988
Reference
2  [PMID:2324704]
  Authors
Navarrete RM, Vara JA, Hutchinson CR
  Title
Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2).
  Journal
J Gen Microbiol 136:273-81 (1990)
DOI:10.1099/00221287-136-2-273
  Sequence
[sco:SCO4089]
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.23
IUBMB Enzyme Nomenclature: 1.4.1.23
ExPASy - ENZYME nomenclature database: 1.4.1.23
BRENDA, the Enzyme Database: 1.4.1.23

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