KEGG   ENZYME: 1.4.3.13Help
Entry
EC 1.4.3.13                 Enzyme                                 

Name
protein-lysine 6-oxidase;
lysyl oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
Reaction(IUBMB)
[protein]-L-lysine + O2 + H2O = [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 [RN:R04239]
Reaction(KEGG)
Substrate
[protein]-L-lysine [CPD:C02188];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
[protein]-(S)-2-amino-6-oxohexanoate [CPD:C03531];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5].
History
EC 1.4.3.13 created 1980, modified 1983
Orthology
K00277  protein-lysine 6-oxidase
Genes
HSA: 4015(LOX)
PTR: 471614(LOX)
PPS: 100978437(LOX)
GGO: 101136249(LOX)
PON: 100457685(LOX)
NLE: 100605848(LOX)
MCC: 699997(LOX)
MCF: 102132184(LOX)
CSAB: 103244411(LOX)
RRO: 104666992(LOX)
RBB: 108520384(LOX)
CJC: 100407991(LOX)
SBQ: 101048786(LOX)
MMU: 16948(Lox)
RNO: 24914(Lox)
CGE: 100764517(Lox)
NGI: 103739770(Lox)
HGL: 101724460(Lox)
CCAN: 109686562(Lox)
OCU: 100357045(LOX)
TUP: 102485593(LOX)
CFA: 481478(LOX)
AML: 100471188(LOX)
UMR: 103670545(LOX)
ORO: 101373448(LOX)
FCA: 101092985(LOX)
PTG: 102972003(LOX)
AJU: 106975167(LOX)
BTA: 280841(LOX)
BOM: 102276831(LOX)
BIU: 109561863(LOX)
PHD: 102330037(LOX)
CHX: 102169472(LOX)
OAS: 101112220(LOX)
SSC: 100525278(LOX)
CFR: 102512711(LOX)
CDK: 105105055
BACU: 103012553(LOX)
LVE: 103078614(LOX)
OOR: 101269698(LOX)
ECB: 100064016(LOX)
EPZ: 103557838(LOX)
EAI: 106842835(LOX)
MYB: 102253224(LOX)
MYD: 102760252(LOX)
HAI: 109379076(LOX)
RSS: 109445545(LOX)
PALE: 102888004(LOX)
LAV: 100658633(LOX)
TMU: 101355891
MDO: 100027065(LOX)
SHR: 100920619(LOX)
OAA: 100076972(LOX)
GGA: 396474(LOX)
CJO: 107306724(LOX)
APLA: 101796992(LOX)
ACYG: 106047401(LOX)
TGU: 100223043(LOX)
GFR: 102041923(LOX)
FAB: 101817182(LOX)
PHI: 102109004(LOX)
PMAJ: 107216161(LOX)
CCAE: 111941266(LOX)
CCW: 104690454(LOX)
FPG: 101917045(LOX)
FCH: 102050081(LOX)
CLV: 102096315(LOX)
EGZ: 104124232(LOX)
ASN: 102380184(LOX)
AMJ: 102559899(LOXL5B) 102571028(LOX)
PSS: 102455646(LOX)
CMY: 102941654(LOX)
CPIC: 101944676(LOX)
ACS: 100558882(lox)
PVT: 110072652 110084345(LOX)
PBI: 103066382(LOX)
GJA: 107121950(LOX)
XLA: 108707204(lox.S) 734204(lox.L)
XTR: 780067(lox)
NPR: 108799190(LOX)
DRE: 404621(loxa)
IPU: 108265136(lox) 108277371(Lox) 108280695(Lox)
ELS: 105014993 105021664(lox)
LCM: 102364058(LOX) 102365752
CMK: 103182380(lox) 103188143
DME: Dmel_CG11335(Loxl1)
 » show all
Taxonomy
Reference
1  [PMID:4838158]
  Authors
Harris ED, Gonnerman WA, Savage JE, O'Dell BL.
  Title
Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta.
  Journal
Biochim Biophys Acta 341:332-44 (1974)
DOI:10.1016/0005-2744(74)90226-5
Reference
2  [PMID:33171]
  Authors
Rayton JK, Harris ED.
  Title
Induction of lysyl oxidase with copper. Properties of an in vitro system.
  Journal
J Biol Chem 254:621-6 (1979)
Reference
3  [PMID:7318]
  Authors
Stassen FL.
  Title
Properties of highly purified lysyl oxidase from embryonic chick cartilage.
  Journal
Biochim Biophys Acta 438:49-60 (1976)
DOI:10.1016/0005-2744(76)90222-9
Reference
4  [PMID:11779117]
  Authors
Palamakumbura AH, Trackman PC.
  Title
A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples.
  Journal
Anal Biochem 300:245-51 (2002)
DOI:10.1006/abio.2001.5464
Reference
5  [PMID:6147351]
  Authors
Kagan HM, Williams MA, Williamson PR, Anderson JM.
  Title
Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates.
  Journal
J Biol Chem 259:11203-7 (1984)
Reference
6  [PMID:20439985]
  Authors
Rodriguez HM, Vaysberg M, Mikels A, McCauley S, Velayo AC, Garcia C, Smith V
  Title
Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor.
  Journal
J Biol Chem 285:20964-74 (2010)
DOI:10.1074/jbc.M109.094136
  Sequence
[hsa:4017]
Reference
7  [PMID:20306300]
  Authors
Kim YM, Kim EC, Kim Y
  Title
The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.
  Journal
Mol Biol Rep 38:145-9 (2011)
DOI:10.1007/s11033-010-0088-0
  Sequence
[hsa:4017]
Reference
8  [PMID:23319596]
  Authors
Xu L, Go EP, Finney J, Moon H, Lantz M, Rebecchi K, Desaire H, Mure M
  Title
Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells.
  Journal
J Biol Chem 288:5357-63 (2013)
DOI:10.1074/jbc.C112.421768
  Sequence
[hsa:4017]
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.13
IUBMB Enzyme Nomenclature: 1.4.3.13
ExPASy - ENZYME nomenclature database: 1.4.3.13
BRENDA, the Enzyme Database: 1.4.3.13
CAS: 99676-44-5

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