KEGG   ENZYME: 1.4.3.21Help
Entry
EC 1.4.3.21                 Enzyme                                 

Name
primary-amine oxidase;
amine oxidase (ambiguous);
amine oxidase (copper-containing);
amine oxidase (pyridoxal containing) (incorrect);
benzylamine oxidase (incorrect);
CAO (ambiguous);
copper amine oxidase (ambiguous);
Cu-amine oxidase (ambiguous);
Cu-containing amine oxidase (ambiguous);
diamine oxidase (incorrect);
diamino oxhydrase (incorrect);
histamine deaminase (ambiguous);
histamine oxidase (ambiguous);
monoamine oxidase (ambiguous);
plasma monoamine oxidase (ambiguous);
polyamine oxidase (ambiguous);
semicarbazide-sensitive amine oxidase (ambiguous);
SSAO (ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
primary-amine:oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2 [RN:R01853]
Reaction(KEGG)
Substrate
RCH2NH2 [CPD:C00375];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
RCHO [CPD:C00071];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A group of enzymes that oxidize primary monoamines but have little or no activity towards diamines, such as histamine, or towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, monoamine oxidase, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. In some mammalian tissues the enzyme also functions as a vascular-adhesion protein (VAP-1).
History
EC 1.4.3.21 created 2007 (EC 1.4.3.6 created 1961, part-incorporated 2008)
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00410  beta-Alanine metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00276  primary-amine oxidase
Genes
HSA: 314(AOC2) 8639(AOC3)
PTR: 107969159 107969160(AOC2) 454702(AOC3)
PPS: 100972002(AOC2) 100973737(AOC3) 100974087
GGO: 101129658 101130613(AOC2) 101132030
PON: 100172863(AOC3) 100445915 100937634(AOC2)
NLE: 100605185 100606201(AOC2)
MCC: 100431015(AOC2) 708053 711820(AOC3)
MCF: 102140322(AOC3) 102141512(AOC2)
CSAB: 103243380 103243381(AOC2) 103243382
RRO: 104659501 104679997 104680006 104680027(AOC2)
RBB: 108526775(AOC2) 108526778
CJC: 100392303(AOC2) 100392670 100413669(AOC3)
SBQ: 101047774
MMU: 11754(Aoc3) 237940(Aoc2)
RNO: 29473(Aoc3)
CGE: 100762635(Aoc2) 100762926
NGI: 103735920(Aoc2) 103735921(Aoc3)
HGL: 101709673(Aoc3) 101721663
CCAN: 109687315 109687342(Aoc2) 109687344(Aoc3)
TUP: 102490650(AOC2) 102491341(AOC3) 102491763
CFA: 480511(AOC3) 490957(AOC2)
AML: 100474209(AOC3) 100481510(AOC2)
UMR: 103672591(AOC2) 103672631(AOC3) 103672632
BTA: 100138645 100336082(AOC2) 281002(AOC3) 789307(SAO)
SSC: 100520329 100520513(AOC2)
CFR: 102514422(AOC3) 102514845(AOC2) 102522004
CDK: 105090482(AOC2) 105090483
LVE: 103076338(AOC2) 103076781(AOC3) 103080265
ECB: 100065718 100065767(AOC3) 100630218(AOC2)
EPZ: 103550339 103550340(AOC3) 103550341(AOC2)
MYB: 102254129(AOC2) 102255007(AOC3) 102256114
PALE: 102897640 102898390(AOC3) 102898638(AOC2)
LAV: 100673883 100675868(AOC2) 100676341(AOC3)
MDO: 100011232(AOC2)
SHR: 100916389 100931056(AOC2)
OAA: 100089720
GGA: 420015(AOC3)
CJO: 107325298 107325299(AOC2)
TGU: 101234248
FAB: 101821363(AOC3)
PHI: 102102104(AOC3) 102102284
CCW: 104697770(AOC3)
AAM: 106491791
PSS: 102463817 102464074(AOC3)
CPIC: 101946562 101946984(AOC2)
XLA: 108702003 108702723 446874(aoc3.L)
XTR: 100497523(aoc2) 594972(aoc3)
DRE: 541429(aoc2)
SRX: 107729559
IPU: 108276610
AMEX: 103033121
TRU: 101069735
LCO: 104927167
MZE: 101476241
OLA: 101156175
XMA: 102227558
PRET: 103468150
NFU: 107391824
HCQ: 109508611
SASA: 100194731(aoc2) 106601268
ELS: 105027621
SFM: 108928058
CMK: 103172692
CRG: 105332360
MYI: 110467306
LAK: 106170052
LJA: Lj0g3v0086469.1(Lj0g3v0086469.1) Lj0g3v0161899.1(Lj0g3v0161899.1) Lj0g3v0161909.1(Lj0g3v0161909.1) Lj0g3v0161929.1(Lj0g3v0161929.1) Lj0g3v0278169.1(Lj0g3v0278169.1) Lj2g3v1242220.1(Lj2g3v1242220.1) Lj4g3v2376120.1(Lj4g3v2376120.1) Lj5g3v1414160.1(Lj5g3v1414160.1) Lj5g3v2046150.1(Lj5g3v2046150.1) Lj5g3v2046160.1(Lj5g3v2046160.1)
DOSA: Os02t0593100-00(Os02g0593100) Os04t0136200-00(Os04g0136200) Os04t0269600-01(Os04g0269600) Os04t0476100-01(Os04g0476100) Os06t0338200-01(Os06g0338200) Os06t0338700-00(Os06g0338700) Os07t0572050-00(Os07g0572050) Os07t0572100-01(Os07g0572100)
ATS: 109758651 109771221 109780093(LOC109780093)
ZMA: 100279491 100383438(pco118120) 103641531
VCN: VOLCADRAFT_84774(amx1)
MIS: MICPUN_56524(MAO)
APRO: F751_0581
ERC: Ecym_7250
KMX: KLMA_60327(AO-I)
PIC: PICST_55523(AMO1) PICST_83878(AMO2)
SLB: AWJ20_132(AMO2) AWJ20_1415(AMO2) AWJ20_2943
NTE: NEUTE1DRAFT85409(NEUTE1DRAFT_85409) NEUTE1DRAFT87576(NEUTE1DRAFT_87576)
ANG: ANI_1_154(An17g00010) ANI_1_156084(An09g01550) ANI_1_1910064(An07g06400) ANI_1_3000024(An02g10920) ANI_1_550114(An13g00710) ANI_1_80034(An03g00730)
PBN: PADG_05360 PADG_07263 PADG_11154 PADG_11456(PADG_02621) PADG_11457(PADG_02621) PADG_11571(PADG_03260)
SPO: SPAC2E1P3.04(cao1) SPBC1289.16c(cao2)
CNE: CNG01110
CNB: CNBG3680
ABP: AGABI1DRAFT110804(AGABI1DRAFT_110804) AGABI1DRAFT31353(AGABI1DRAFT_31353)
ABV: AGABI2DRAFT113718(AGABI2DRAFT_113718) AGABI2DRAFT196562(AGABI2DRAFT_196562) AGABI2DRAFT213491(AGABI2DRAFT_213491)
SMIN: v1.2.024444.t1(symbB.v1.2.024444.t1) v1.2.036815.t1(symbB.v1.2.036815.t1) v1.2.036815.t2(symbB.v1.2.036815.t2) v1.2.036815.t3(symbB.v1.2.036815.t3) v1.2.036815.t4(symbB.v1.2.036815.t4)
ECO: b1386(tynA)
ECJ: JW1381(tynA)
ECD: ECDH10B_1511(tynA)
EBW: BWG_1215(tynA)
EOJ: ECO26_1990(tynA)
EOI: ECO111_1780(tynA)
EOH: ECO103_1523(tynA)
ECX: EcHS_A1473(tynA)
ECW: EcE24377A_1571(tynA)
ECY: ECSE_1471
ECR: ECIAI1_1386(tynA)
ECK: EC55989_1522(tynA)
ELH: ETEC_1461
ESO: O3O_12090(tynA)
ESM: O3M_13515(tynA)
ESL: O3K_13540(tynA)
EBR: ECB_01358(tynA)
EKF: KO11_15190(tynA)
EDJ: ECDH1ME8569_1331(tynA)
ELW: ECW_m1520(tynA)
ELL: WFL_07425(tynA)
ELP: P12B_c1740(tynA)
EBL: ECD_01358(tynA)
ECOA: APECO78_10665(tynA)
ECOL: LY180_07250(tynA)
ECOO: ECRM13514_2000(tynA)
ECOH: ECRM13516_1753(tynA)
EFE: EFER_1611(tynA)
SHQ: A0259_11045(tynA)
ENC: ECL_02157
ENO: ECENHK_10295(tynA)
EEC: EcWSU1_02051(tynA)
ENL: A3UG_10315(tynA)
ECLE: ECNIH2_10890(tynA)
ECLN: ECNIH4_12430(tynA)
ECLI: ECNIH5_11735(tynA)
ECLX: LI66_10230(tynA)
ECLY: LI62_11030(tynA)
ECLZ: LI64_10380(tynA)
ECLA: ECNIH3_10055(tynA)
ECLC: ECR091_10025(tynA)
EAU: DI57_08545(tynA)
EHM: AB284_14780(tynA)
EKB: BFV64_10660(tynA)
ELG: BH714_06510(tynA)
EXF: BFV63_10415(tynA)
ECLS: LI67_015505(tynA)
ENX: NI40_010420(tynA)
KPN: KPN_01467(tynA)
KPU: KP1_2469(tynA)
KPP: A79E_2773
KPK: A593_21840(tynA)
KPH: KPNIH24_16380(tynA)
KPZ: KPNIH27_11540(tynA)
KPV: KPNIH29_11765(tynA)
KPW: KPNIH30_12305(tynA)
KPY: KPNIH31_11390(tynA)
KPG: KPNIH32_12145(tynA)
KPC: KPNIH10_11850(tynA)
KPQ: KPR0928_11860(tynA)
KPT: VK055_1043(maoA)
KPE: KPK_3002(tynA)
KPO: KPN2242_10115(tynA)
KPR: KPR_2876(maoA)
KPI: D364_07185(tynA)
KPX: PMK1_03785(maoA)
KPB: FH42_03230(tynA)
KPNE: KU54_014355(tynA)
KPNU: LI86_14290(tynA)
KPNK: BN49_2528(maoA)
KVA: Kvar_2900
KVD: KR75_19660(tynA)
KVQ: SP68_00700(tynA)
KOX: KOX_19410(tynA)
KOE: A225_2752
KOY: J415_18220(tynA)
KMI: VW41_11840(tynA)
KOK: KONIH1_13480(tynA)
KOC: AB185_21610(tynA)
KOM: HR38_17740(tynA)
KQU: AVR78_16375(tynA)
EAE: EAE_20530(tynA)
EAR: CCG29775
EBT: EBL_c16540(tynA)
ROR: RORB6_07560(tynA)
RON: TE10_12980(tynA)
RPLN: B1209_14680(tynA)
CNT: JT31_00450(tynA)
CEM: LH23_16445(tynA)
CEN: LH86_15435(tynA)
PGE: LG71_17870(tynA)
KLE: AO703_10115(tynA)
LAX: APT61_10015(tynA)
EBF: D782_2334
SFW: WN53_13885(tynA)
SFG: AV650_09435(tynA)
HAV: AT03_19260(tynA)
OPO: DSM2777_06135(tynA)
PPI: YSA_08839
PPSY: AOC04_06075(tynA)
PSPG: AK823_04885(tynA)
PSYG: AK825_04900(tynA)
ACB: A1S_1854
ABY: ABAYE1710(tynA)
ABN: AB57_2189(tynA)
ABX: ABK1_2433
ABH: M3Q_2314
ABAD: ABD1_18770
ABAZ: P795_7480
ABK: LX00_09950(tynA)
ABAA: IX88_11450(tynA)
ABW: BL01_00770(tynA)
ACC: BDGL_001334(tynA)
ALC: OTEC02_08205(tynA)
ACD: AOLE_08570(tynA)
ACW: A0J50_07930(tynA)
LPN: lpg2910(tynA)
LPH: LPV_3277(tynA)
LPO: LPO_3228(tynA)
LPM: LP6_2945(tynA)
LPP: lpp2979
LPC: LPC_3213(tynA)
LPA: lpa_04254(tynA)
LPE: lp12_2898
RSN: RSPO_m00628(tynA)
BFN: OI25_3600
HSE: Hsero_3531(tynA)
HSZ: ACP92_17605(tynA)
HRB: Hrubri_2912(tynA)
MLO: mll6250
ARA: Arad_9757
ATF: Ach5_50140(tynA)
RLE: RL3036
SHZ: shn_15985
BJP: RN69_25505(tynA)
BRA: BRADO6525
BBT: BBta_1115
BRC: BCCGELA001_19020(tynA)
BIC: LMTR13_34190(tynA)
RPB: RPB_1133
HMC: HYPMC_0415(maoI)
PSF: PSE_p0337
APK: APA386B_241(tynA)
TMO: TMO_3343(maoI)
PHR: C6569_18505(tynA)
BACI: B1NLA3E_18970(tynA)
PSAB: PSAB_02300(tynA)
PDU: PDUR_11695(tynA)
PBJ: VN24_01135(tynA)
MMC: Mmcs_2000
MKM: Mkms_2046
MJL: Mjls_1981
MMI: MMAR_2608(maoX)
MMAE: MMARE11_25280(maoX)
MYE: AB431_10905(tynA)
MSM: MSMEG_2526(tynA) MSMEG_3847(tynA)
MPHL: MPHLCCUG_02168(maoII)
MVQ: MYVA_2137(tynA1) MYVA_3313(tynA2)
MLL: B1R94_18195(tynA)
MAB: MAB_4204
MABB: MASS_4239(tynA)
MABO: NF82_21060
MCHE: BB28_21655
MSTE: MSTE_04379
NFA: NFA_27860
RFA: A3L23_02739(maoII)
RHS: A3Q41_00622(maoII_1) A3Q41_02889(maoII_2) A3Q41_02971 A3Q41_04734(maoII_3)
SCT: SCAT_5049
SBH: SBI_01422(tynA) SBI_03047
SVE: SVEN_5900
SLD: T261_6537
SRW: TUE45_06711(maoII)
SLE: sle_15920(sle_15920)
SFK: KY5_6313
FRP: AX769_11170(tynA)
ART: Arth_3502
ARU: ASPU41_05960(tynA) ASPU41_06040(tynA)
ACH: Achl_3572
PSUL: AU252_12820(tynA)
XCE: Xcel_3066
BLIN: BLSMQ_0725
MPH: MLP_35100
AEZ: C3E78_16630(tynA) C3E78_16735(tynA)
SRO: Sros_8167
NML: Namu_4963
MMAR: MODMU_2097(maoI) MODMU_4206
AOI: AORI_3584(tynA)
SESP: BN6_34440
ALL: CRK57855
MIL: ML5_5868
ASE: ACPL_3926(tynA)
ACTN: L083_3311 L083_5454(tynA)
AFS: AFR_19155
ACTS: ACWT_3798
CAI: Caci_2627
CWO: Cwoe_3876
CYA: CYA_1346
CYB: CYB_2794
LET: O77CONTIG1_02108(maoII)
TER: Tery_1383
ANA: alr3431
NON: NOS3756_51710(tynA)
AVA: Ava_3451
ANB: ANA_C12068(tynA)
CTHE: Chro_3560
HAU: Haur_3112
STI: Sthe_2982
GES: VT84_32830(maoII)
PBOR: BSF38_03571(maoII_1) BSF38_05460(maoII_2)
ABAC: LuPra_06110(maoA)
GBA: J421_1449
HJE: HacjB3_18513(tynA) HacjB3_18623(tynA)
NMO: Nmlp_3583
SSO: SSO1692(tynA)
SOL: Ssol_2477
SSOA: SULA_2500(tynA)
SSOL: SULB_2503(tynA)
SSOF: SULC_2498(tynA)
SAI: Saci_2182(tynA)
SACN: SacN8_10625(tynA)
SACR: SacRon12I_10875(tynA)
SII: LD85_3011
SIH: SiH_2646
 » show all
Taxonomy
Reference
1  [PMID:7337701]
  Authors
Haywood GW, Large PJ.
  Title
Microbial oxidation of amines. Distribution, purification and properties of two primary-amine oxidases from the yeast Candida boidinii grown on amines as sole nitrogen source.
  Journal
Biochem J 199:187-201 (1981)
Reference
2  [PMID:7622512]
  Authors
Tipping AJ, McPherson MJ.
  Title
Cloning and molecular analysis of the pea seedling copper amine oxidase.
  Journal
J Biol Chem 270:16939-46 (1995)
DOI:10.1074/jbc.270.28.16939
  Sequence
Reference
3  [PMID:8920635]
  Authors
Lyles GA.
  Title
Mammalian plasma and tissue-bound semicarbazide-sensitive amine oxidases: biochemical, pharmacological and toxicological aspects.
  Journal
Int J Biochem Cell Biol 28:259-74 (1996)
DOI:10.1016/1357-2725(95)00130-1
Reference
4  [PMID:9405045]
  Authors
Wilce MC, Dooley DM, Freeman HC, Guss JM, Matsunami H, McIntire WS, Ruggiero CE, Tanizawa K, Yamaguchi H.
  Title
Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the holo and apo forms: implications for the biogenesis of topaquinone.
  Journal
Biochemistry 36:16116-33 (1997)
DOI:10.1021/bi971797i
  Sequence
Reference
5  [PMID:9677370]
  Authors
Lee Y, Sayre LM.
  Title
Reaffirmation that metabolism of polyamines by bovine plasma amine oxidase occurs strictly at the primary amino termini.
  Journal
J Biol Chem 273:19490-4 (1998)
DOI:10.1074/jbc.273.31.19490
Reference
6  [PMID:10668504]
  Authors
Houen G.
  Title
Mammalian Cu-containing amine oxidases (CAOs): new methods of analysis, structural relationships, and possible functions.
  Journal
APMIS Suppl 96:1-46 (1999)
Reference
7  [PMID:11156689]
  Authors
Andres N, Lizcano JM, Rodriguez MJ, Romera M, Unzeta M, Mahy N.
  Title
Tissue activity and cellular localization of human semicarbazide-sensitive amine oxidase.
  Journal
J Histochem Cytochem 49:209-17 (2001)
DOI:10.1177/002215540104900208
Reference
8  [PMID:11985492]
  Authors
Saysell CG, Tambyrajah WS, Murray JM, Wilmot CM, Phillips SE, McPherson MJ, Knowles PF.
  Title
Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a substrate analogue.
  Journal
Biochem J 365:809-16 (2002)
DOI:10.1042/BJ20011435
Reference
9  [PMID:14697905]
  Authors
O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, Tipton KF.
  Title
Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do.
  Journal
Neurotoxicology 25:303-15 (2004)
DOI:10.1016/S0161-813X(03)00117-7
Reference
10 [PMID:16046623]
  Authors
Airenne TT, Nymalm Y, Kidron H, Smith DJ, Pihlavisto M, Salmi M, Jalkanen S, Johnson MS, Salminen TA.
  Title
Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications.
  Journal
Protein Sci 14:1964-74 (2005)
DOI:10.1110/ps.051438105
  Sequence
[hsa:8639]
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.21
IUBMB Enzyme Nomenclature: 1.4.3.21
ExPASy - ENZYME nomenclature database: 1.4.3.21
BRENDA, the Enzyme Database: 1.4.3.21

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