KEGG   ENZYME: 1.4.3.3Help
Entry
EC 1.4.3.3                  Enzyme                                 

Name
D-amino-acid oxidase;
ophio-amino-acid oxidase;
L-amino acid:O2 oxidoreductase;
new yellow enzyme
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
D-amino-acid:oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
a D-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 [RN:R01340]
Reaction(KEGG)
Substrate
D-amino acid [CPD:C00405];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
2-oxo carboxylate [CPD:C00161];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). Wide specificity for D-amino acids. Also acts on glycine.
History
EC 1.4.3.3 created 1961
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00311  Penicillin and cephalosporin biosynthesis
ec00330  Arginine and proline metabolism
ec00472  D-Arginine and D-ornithine metabolism
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K00273  D-amino-acid oxidase
Genes
HSA: 1610(DAO)
PTR: 743881(DAO)
PPS: 100989465(DAO)
GGO: 101127462(DAO)
PON: 100171568(DAO)
NLE: 100584283(DAO)
MCC: 706373(DAO)
MCF: 102146162(DAO)
CSAB: 103239076(DAO)
RRO: 104660225(DAO)
RBB: 108534390(DAO)
CJC: 100414426(DAO)
SBQ: 101033399(DAO)
MMU: 13142(Dao)
RNO: 114027(Dao)
CGE: 100689280(Dao)
NGI: 103746689(Dao)
HGL: 101715888(Dao)
CCAN: 109688605(Dao)
OCU: 100008977(DAO)
TUP: 102484475(DAO)
CFA: 486317(DAO)
AML: 100477150(DAO)
UMR: 103678301(DAO)
ORO: 101364868(DAO)
FCA: 101087429(DAO)
PTG: 102965053(DAO)
AJU: 106978240(DAO)
BTA: 615334(DAO)
BOM: 102288350(DAO)
BIU: 109571467(DAO)
PHD: 102329366(DAO)
CHX: 102179224(DAO)
OAS: 101115829(DAO)
SSC: 397134(DAO)
CFR: 102513211(DAO)
CDK: 105105351(DAO)
BACU: 103017643(DAO)
LVE: 103091527(DAO)
OOR: 101271460(DAO)
ECB: 100059819(DAO)
EPZ: 103551429(DAO)
EAI: 106848086(DAO)
MYB: 102240841(DAO)
MYD: 102759757(DAO)
HAI: 109386138(DAO)
RSS: 109461325(DAO)
PALE: 102889021(DAO)
LAV: 100658336(DAO)
TMU: 101352892
MDO: 100024682(DAO)
SHR: 100929799(DAO)
OAA: 100082667(DAO)
GGA: 101751055(DAO)
MGP: 100538439(DAO)
CJO: 107321301(DAO)
APLA: 101803259(DAO)
ACYG: 106031397(DAO)
TGU: 100227661(DAO)
GFR: 102034289(DAO)
FAB: 101819437(DAO)
PHI: 102104947(DAO)
PMAJ: 107211508(DAO)
CCW: 104688662(DAO)
FPG: 101911513(DAO)
FCH: 102057845(DAO)
CLV: 102098809
EGZ: 104123874(DAO)
ASN: 102368994(DAO)
AMJ: 102564813(DAO)
PSS: 102462192(DAO)
CMY: 102942158(DAO)
CPIC: 101943950(DAO)
ACS: 100557335(dao)
PVT: 110083399(DAO)
PBI: 103066152(DAO)
GJA: 107112177(DAO)
XLA: 735104(dao.L)
XTR: 100036595(dao)
NPR: 108790561(DAO)
DRE: 402994(dao.3) 405800(dao.2) 565385(zgc:172341) 619259(dao.1)
SRX: 107741224
SANH: 107654625
SGH: 107597279
CCAR: 109090353
IPU: 108256012(dao)
AMEX: 103023242(dao)
TRU: 101077517(dao)
LCO: 104937256(dao)
NCC: 104962061(dao)
MZE: 101486371(dao)
OLA: 101166138(dao)
XMA: 102218661(dao)
PRET: 103470317(dao)
NFU: 107393981(dao)
CSEM: 103397332(dao)
LCF: 108878198(dao)
HCQ: 109511661(dao)
BPEC: 110169884(dao)
SASA: 100306742(dao)
ELS: 105025596(dao)
SFM: 108932590(dao)
LCM: 102345246(DAO)
CMK: 103184038(dao)
DME: Dmel_CG11236(CG11236)
DER: 6542841
DPE: 6593724
DSI: Dsimw501_GD23432(Dsim_GD23432)
DWI: 6644163
MDE: 101888461
AAG: 5569995
BIM: 105681513
BTER: 105666640
SOC: 105202771
AEC: 105145415
ACEP: 105618099
HST: 105192340
CFO: 105259382
LHU: 105672919
TCA: 663711
DPA: 109541460
NVL: 108567539
BMOR: 101737245
PMAC: 106714654
PRAP: 111003257
PXY: 105398389
ZNE: 110829339
CEL: CELE_Y69A2AR.5(daao-1)
CBR: CBG13882
MYI: 110445951
OBI: 106873074
LAK: 106171871
HMG: 101234772
KMX: KLMA_10437(DAO1)
TPF: TPHA_0A02240(TPHA0A02240)
PIC: PICST_57912(DAO1)
CAL: CAALFM_C103670CA(DAO1)
CAUR: QG37_07357
NCR: NCU06558
MGR: MGG_08011
MAW: MAC_01437
MAJ: MAA_07041
ANI: AN0174.2
ANG: ANI_1_320014(An01g02430)
MGL: MGL_4170
DDI: DDB_G0273291(ddo-2) DDB_G0273783(ddo-1)
AZO: azo1919
SCL: sce5330(aao)
MTU: Rv1905c(aao)
MTC: MT1956
MRA: MRA_1916(aao)
MTUR: CFBS_1999(aao)
MTO: MTCTRI2_1938(aao)
MTD: UDA_1905c(aao)
MTN: ERDMAN_2097(aao)
MTUC: J113_13175
MTUE: J114_10155
MTUH: I917_13495
MTUL: TBHG_01861
MTUT: HKBT1_1996(aao)
MTUU: HKBT2_2004(aao)
MTQ: HKBS1_2000(aao)
MBB: BCG_1944c(aao)
MBT: JTY_1928(aao)
MBM: BCGMEX_1925c(aao)
MBX: BCGT_1736
MAF: MAF_19280(aao)
MCE: MCAN_19211(aao)
MCQ: BN44_40175(aao)
MCV: BN43_31054(aao)
MCX: BN42_30196(aao)
MCZ: BN45_50176(aao)
MLE: ML2011(aao)
MLB: MLBr02011(aao)
MPA: MAP_1629c(aao)
MAO: MAP4_2210
MAV: MAV_2796
MIT: OCO_26270
MIA: OCU_26140
MID: MIP_03675
MYO: OEM_24760
MIR: OCQ_24850
MUL: MUL_1659(aao_1) MUL_2926(aao)
MMI: MMAR_2477(aao_1) MMAR_2801(aao)
MMM: W7S_12760
MLI: MULP_02569(aao)
TPR: Tpau_3499
SCO: SCO6740(SC5F2A.23c)
SALB: XNR_0297
SMA: SAVERM_1672(dao)
SGR: SGR_986
SFA: Sfla_0667
SBH: SBI_02634
SHY: SHJG_7634
SDV: BN159_1680(aao)
SALS: SLNWT_0394
STRP: F750_6201
SALU: DC74_6759
STRE: GZL_02007
SAMB: SAM23877_6390(aao)
AAI: AARI_18930(dao)
NCA: Noca_1780
GOB: Gobs_3505
SEN: SACE_0979(aao)
AMD: AMED_2680
AMN: RAM_13625
AMM: AMES_2653
AMZ: B737_2654
AOI: AORI_2663
AMI: Amir_4180
SESP: BN6_43740
KAL: KALB_8361
ASE: ACPL_1689(aao)
AFS: AFR_24570
SNA: Snas_1168
RXY: Rxyl_0526
 » show all
Taxonomy
Reference
1  [PMID:14314378]
  Authors
DIXON M, KLEPPE K.
  Title
D-AMINO ACID OXIDASE. I. DISSOCIATION AND RECOMBINATION OF THE HOLOENZYME.
  Journal
Biochim Biophys Acta 96:357-67 (1965)
DOI:10.1016/0005-2787(65)90556-3
Reference
2
  Authors
Dixon, M. and Kleppe, K.
  Title
D-Amino acid oxidase. II. Specificity, competitive inhibition and reaction sequence.
  Journal
Biochim Biophys Acta 96:368-382 (1965)
Reference
3  [PMID:14314379]
  Authors
DIXON M, KLEPPE K.
  Title
D-AMINO ACID OXIDASE. 3. EFFECT OF PH.
  Journal
Biochim Biophys Acta 96:383-9 (1965)
DOI:10.1016/0005-2787(65)90558-7
Reference
4  [PMID:13767909]
  Authors
MASSEY V, PALMER G, BENNETT R.
  Title
The purification and some properties of D-amino acid oxidase.
  Journal
Biochim Biophys Acta 48:1-9 (1961)
DOI:10.1016/0006-3002(61)90508-X
Reference
5
  Authors
Meister, A. and Wellner, D.
  Title
Flavoprotein amino acid oxidase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 609-648.
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.3
IUBMB Enzyme Nomenclature: 1.4.3.3
ExPASy - ENZYME nomenclature database: 1.4.3.3
BRENDA, the Enzyme Database: 1.4.3.3
CAS: 9000-88-8

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